consiral 50 capsule - Ciclosporin (50mg) medicine

consiral 50 capsule

4.7 (12 reviews)
Ciclosporin (50mg)
๐Ÿญ Emcure Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is consiral 50 capsule used for?

Arpimune ME 50mg Capsule (Ciclosporin) is used to treat OPHTHAL. It contains Ciclosporin (50mg), which Inhibits calcineurin, thereby preventing dephosphorylation and nuclear transloca. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ciclosporin
  • Manufacturer: Emcure Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š consiral 50 capsule Uses & Benefits

Prophylaxis of organ transplant rejection; rheumatoid arthritis; psoriasis; nephrotic syndrome; dry eye disease (ophthalmic).

Off-label uses: Severe atopic dermatitis; ulcerative colitis; aplastic anemia.

๐Ÿ“‹ Drug Information

Generic Name(s)Ciclosporin
Brand NameArpimune ME 50mg Capsule
ManufacturerEmcure Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassImmunosuppressant- Calcineurin inhibitors
Route of AdministrationOral
StorageStore at 15-30ยฐC in a dry place; protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed slowly and incompletely from the gastrointestinal tract; oral bioavailability is variable (20-50%).
DistributionWidely distributed in body tissues; crosses placenta; enters breast milk.
Protein Binding90-98% bound to plasma proteins, mainly lipoproteins.
MetabolismExtensively metabolized in the liver by CYP3A4 to multiple metabolites.
Half-LifeApproximately 19 hours (range 10-27 hours).
ExcretionPrimarily excreted in bile and feces; only 6% excreted in urine.
Bioavailability20-50% (oral); variable.
Onset of Action2-4 hours (oral).
Peak Plasma Time1.5-4 hours (oral).
Duration of Action12-24 hours.

How It Works

Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines, suppressing T-cell activation.

Mechanism Steps

1Ciclosporin binds to cyclophilin in T-cells.
2Complex inhibits calcineurin phosphatase activity.
3Prevents dephosphorylation of NF-AT.

๐Ÿ’ก How to Take consiral 50 capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of consiral 50 capsule

โœ… Common Side Effects

  • Nephrotoxicity
  • Hypertension
  • Tremor
  • Hirsutism
  • Gingival hyperplasia
  • Gastrointestinal disturbances
  • Hyperlipidemia

๐Ÿšจ Serious Side Effects

  • Acute or chronic nephrotoxicity
  • Hepatotoxicity
  • Neurotoxicity (seizures, encephalopathy)
  • Lymphoma
  • Opportunistic infections
  • Thrombotic microangiopathy

โš ๏ธ Rare Side Effects

  • Anaphylaxis
  • Hemolytic uremic syndrome
  • Pancreatitis
  • Myopathy
  • Gynecomastia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Potassium-sparing diuretics Major Increased risk of hyperkalemia
ACE inhibitors Major Increased risk of hyperkalemia and nephrotoxicity
NSAIDs Major Increased nephrotoxicity risk
Live vaccines Major Risk of disseminated infection
Ketoconazole Moderate Increased ciclosporin levels
Rifampin Moderate Decreased ciclosporin levels
Grapefruit juice Minor Increased ciclosporin levels

๐Ÿšจ Major Interactions

  • Potassium-sparing diuretics
  • ACE inhibitors
  • ARBs
  • Methotrexate
  • Colchicine
  • NSAIDs
  • Live vaccines

โšก Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP3A4 inducers (e.g., rifampin, phenytoin)
  • Statins
  • Digoxin
  • Prednisolone

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Calcium channel blockers (e.g., diltiazem, verapamil)
  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice increases bioavailability; avoid. Food may decrease absorption; take consistently with or without food.

๐Ÿท Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid excessive consumption.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to ciclosporin; uncontrolled hypertension; active infections; malignancy; concurrent PUVA or UVB therapy.

๐Ÿ“Š Monitoring Parameters

Blood pressure, renal function (serum creatinine, BUN), liver function tests, ciclosporin trough levels, electrolytes (especially potassium), lipid profile.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; monitor renal function, liver function, and electrolytes; no specific antidote.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for consiral 50 capsule

View All

Alternative brands with exact same active ingredient (Ciclosporin (50mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

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