Bacigyl-N Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Sudden tendon pain or swelling
- Numbness or tingling in hands or feet
- Seizures or convulsions
- Difficulty breathing or swelling of face
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is comeba suspension used for?
This medicine is a prescription antibiotic suspension containing Metronidazole and Norfloxacin. It is used to treat infectious diarrhea, amebic dysentery, and giardiasis. It works by killing bacteria and parasites in the gut. It should be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Metronidazole + Norfloxacin
- Manufacturer: Alembic Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 comeba suspension के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल और नोरफ्लोक्सासिन का संयोजन है, जिसका उपयोग संक्रामक दस्त, अमीबिक पेचिश और गियार्डिया के इलाज के लिए किया जाता है। यह आंतों में बैक्टीरिया और परजीवियों को मारती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, धातु जैसा स्वाद, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रिया शामिल हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बीच में न छोड़ें। शराब का सेवन बिल्कुल न करें। पर्याप्त पानी पिएं। एंटासिड या आयरन की गोलियों के साथ सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 comeba suspension Uses & Benefits
[{"condition":"Infectious diarrhea","description":"Used to treat diarrhea caused by susceptible bacteria such as Escherichia coli, Salmonella, and Shigella species.","evidence":"Well-established"},{"condition":"Amebic dysentery","description":"Effective against Entamoeba histolytica, a parasite that causes bloody diarrhea and abdominal pain.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Treats infection with Giardia lamblia, a parasite that causes prolonged diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Metronidazole component is effective, but norfloxacin is not typically used for this indication; combination is not standard.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diverticulitis","description":"Sometimes used in combination regimens for acute diverticulitis, but not a standard first-line choice.","evidence":"Limited"},{"condition":"Pelvic inflammatory disease","description":"May be used as part of a broader regimen, but norfloxacin is not a preferred agent.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea
Also treats: Amebic dysentery, Giardiasis, Bacterial gastroenteritis
📋 Drug Information
| Generic Name(s) | Metronidazole + Norfloxacin |
| Brand Name | Bacigyl-N Suspension |
| Manufacturer | Alembic Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic, Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. Shake well before each use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with distinct mechanisms. Metronidazole enters anaerobic organisms and forms reactive metabolites that damage DNA, leading to cell death. Norfloxacin inhibits DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and repair. The combination targets both anaerobic and aerobic bacteria, providing broad coverage in the gut.
Mechanism Steps
💡 How to Take comeba suspension
Strength: Each 5 mL of suspension contains Metronidazole 100 mg and Norfloxacin 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this suspension is 5 mL (containing 100 mg metronidazole and 100 mg norfloxacin) taken orally twice daily, or as directed by your physician. The duration of treatment depends on the type and severity of infection, typically 5 to 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are more susceptible to side effects. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For norfloxacin, creatinine clearance less than 30 mL/min requires dose reduction. Metronidazole dose may also need adjustment in severe renal impairment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | In patients with severe liver disease, metronidazole dose should be reduced due to impaired metabolism. Norfloxacin should be used with caution. Monitor liver function closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 10 mL (200 mg metronidazole and 200 mg norfloxacin) in divided doses, but this may vary based on indication and physician's judgment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of comeba suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Lithium | Moderate | |
| Caffeine | Minor | |
| Iron supplements | Minor | |
| Dairy products | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Antacids containing aluminum or magnesium
- Theophylline
⚡ Moderate Interactions
- Cimetidine
- Phenytoin
- Lithium
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction with alcohol, leading to severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to metronidazole, norfloxacin, or other fluoroquinolones","Myasthenia gravis","History of tendon disorders with fluoroquinolones","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding","Severe liver disease","Severe kidney disease (dose adjustment needed)","Children under 18 years (norfloxacin not recommended)","Alcohol use during treatment"]
⚠️ Warnings & Precautions
["Avoid alcohol during and for 48 hours after treatment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","May cause photosensitivity; avoid prolonged sun exposure and use sunscreen.","Serious tendon reactions can occur; stop and consult doctor if tendon pain occurs.","Peripheral neuropathy may occur; report numbness or tingling.","May worsen muscle weakness in myasthenia gravis; avoid use.","Use with caution in patients with epilepsy or CNS disorders.","May cause blood sugar disturbances; monitor if diabetic.","Do not use for viral infections; it is ineffective.","Complete the full course to prevent resistance."]
🤱 Lactation Safety
Metronidazole passes into breast milk and may affect the nursing infant. Norfloxacin also passes into breast milk. Breastfeeding is not recommended while taking this medicine. If treatment is essential, discuss with your doctor about temporary cessation of breastfeeding or alternative options.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and in severe cases, seizures or tendon damage. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause severe nausea and vomiting. Drink plenty of fluids to stay hydrated. Do not take antacids or iron supplements within two hours of this medicine. Inform your doctor if you have kidney or liver problems, epilepsy, or myasthenia gravis. Avoid driving if you feel dizzy. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney impairment, and CNS effects. Dose adjustment may be needed based on renal function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Norfloxacin is not recommended during pregnancy. Use effective contraception while on this medicine and discuss alternatives.
🏥 Post-Surgery Considerations
Inform your surgeon if you are taking this medicine before any surgery. It may interact with anesthetics and other medications. Your doctor may advise stopping it temporarily.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain antibiotics used in dentistry. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon injury. Light activity is fine if you feel up to it.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take rest as needed. It is advisable to stay home while you are contagious.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor, even if you feel better. Stopping early can lead to relapse and antibiotic resistance. If you experience serious side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, gut flora imbalance, and rare but serious effects like peripheral neuropathy or tendon damage. It is not intended for prolonged use. Regular monitoring of liver and kidney function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhea.
Evidence: Well-establishedMay help restore gut flora after antibiotic treatment.
Evidence: ModerateCan reduce duration of diarrhea in children.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Avoid taking live vaccines during treatment. Consult your doctor for vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but complete the full course as prescribed.
A: Inform your doctor about all medicines you take, especially warfarin, antacids, and theophylline.
A: Norfloxacin is not recommended in pregnancy. Consult your doctor for alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for comeba suspension
View AllAlternative brands with exact same active ingredient:
-
endar suspensionEsquire Drug House ₹9.38 6.2% CHEAPER
-
markdryl syrupGlenmark Pharmaceuticals Ltd ₹9.38 6.2% CHEAPER
-
dakson m 100 mg/100 mg syrupEmcee Pharmaceuticals Pvt Ltd ₹10.03 0.3% COSTLIER
-
metroxa suspensionParenteral Drugs India Ltd ₹10.55 5.5% COSTLIER
-
supergyl 100 mg/100 mg suspensionLupin Ltd ₹10.78 7.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: It only works for specific bacterial and parasitic infections. Viral diarrhea will not respond. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full course to prevent resistance and relapse. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe reaction with metronidazole. Avoid completely.
🔄 Alternative Options
Generic Alternatives
- Metronidazole + Norfloxacin suspension (generic)
Brand Alternatives
- Bacigyl-N Suspension