combidom tablet
What is combidom tablet used for?
Acurac 10 mg/150 mg Tablet (Domperidone + Ranitidine) is used to treat GASTRO INTESTINAL. It contains Domperidone (10mg) + Ranitidine (150mg), which Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal . Always consult your doctor before use. Take as prescribed.
- Generic Name: Domperidone + Ranitidine
- Manufacturer: Glosun Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ combidom tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Ranitidine |
| Brand Name | Acurac 10 mg/150 mg Tablet |
| Manufacturer | Glosun Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + H2 receptor antagonist |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal motility; Ranitidine is a competitive H2 receptor antagonist that reduces gastric acid secretion.
Mechanism Steps
๐ก How to Take combidom tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of combidom tablet
โ Common Side Effects
- Dry mouth
- Headache
- Dizziness
- Diarrhea
- Constipation
- Fatigue
๐จ Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Extrapyramidal symptoms
- Gynecomastia
- Galactorrhea
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Anaphylaxis
- Angioedema
- Bronchospasm
- Agranulocytosis
- Thrombocytopenia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased risk of QT prolongation due to CYP3A4 inhibition |
| Erythromycin | Major | Increased risk of cardiac arrhythmias |
| Warfarin | Moderate | Possible increased INR and bleeding risk |
| Antacids | Moderate | Reduced absorption of ranitidine if taken simultaneously |
๐จ Major Interactions
- Ketoconazole
- Erythromycin
- Clarithromycin
- Itraconazole
- Voriconazole
- Fluconazole
- Ritonavir
- Saquinavir
- Amiodarone
- Dronedarone
โก Moderate Interactions
- Warfarin
- Theophylline
- Phenytoin
- Procainamide
- Cimetidine
- Sucralfate
- Antacids
- Metoclopramide
- Opioids
- Anticholinergics
โน๏ธ Minor Interactions
- Digoxin
- Triazolam
- Midazolam
- Diazepam
- Propranolol
- Metoprolol
- Nifedipine
๐ฝ๏ธ Food Interactions
Food may decrease absorption of domperidone; ranitidine absorption may be slightly increased by food.
๐ท Alcohol Interaction
Alcohol may increase gastric irritation and worsen side effects; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components, gastrointestinal hemorrhage, mechanical obstruction or perforation, prolactinoma, known QT prolongation, concomitant use of strong CYP3A4 inhibitors.
๐ Monitoring Parameters
ECG for QT interval, renal function, liver function, serum electrolytes, signs of extrapyramidal symptoms.
๐คฑ Lactation Safety
Domperidone: Excreted in breast milk, may cause adverse effects in infant; Ranitidine: Excreted in b
๐ Overdose Management
Supportive care; ECG monitoring for QT prolongation; activated charcoal if recent ingestion; domperidone may cause extrapyramidal reactions (treat with anticholinergics).
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.