Accurate 10 mg/150 mg Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Uncontrolled muscle spasms or tremors
- Swelling of face, lips, or throat
- Difficulty breathing
- Blood in vomit or black stools
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is combidom tablet used for?
This medicine is a combination of domperidone and ranitidine used to treat acid reflux, heartburn, and nausea. It works by reducing stomach acid and improving stomach emptying. It is usually taken before meals for up to 14 days.
- Generic Name: Domperidone + Ranitidine
- Manufacturer: Glosun Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 combidom tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और रैनिटिडीन का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, सीने में जलन, अपच और मतली के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है। इसे आमतौर पर खाने से पहले लिया जाता है और डॉक्टर की सलाह के बिना 14 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, सिरदर्द, चक्कर आना, दस्त और पेट में ऐंठन शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, स्तन में दर्द या सूजन, और मांसपेशियों में ऐंठन शामिल हो सकते हैं। यदि आपको कोई गंभीर लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक या अवधि से अधिक न लें। इस दवा के साथ शराब का सेवन न करें। यदि आपको हृदय, यकृत या गुर्दे की समस्या है, या आप अन्य दवाएं ले रहे हैं, तो अपने डॉक्टर को बताएं। 14 दिनों से अधिक समय तक बिना डॉक्टर की सलाह के इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें।
💊 combidom tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux symptoms such as heartburn and regurgitation by decreasing stomach acid production and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Relieves upper abdominal discomfort, bloating, and early satiety by promoting gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with gastroparesis","description":"Domperidone helps accelerate stomach emptying and reduces nausea, while ranitidine reduces acid irritation.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed to improve gastric emptying in diabetic patients, though not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting
📋 Drug Information
| Generic Name(s) | Domperidone + Ranitidine |
| Brand Name | Acurac 10 mg/150 mg Tablet |
| Manufacturer | Glosun Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + H2 receptor antagonist |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and in the gastrointestinal tract, which enhances gastric motility and reduces nausea. Ranitidine competitively blocks histamine H2 receptors on gastric parietal cells, leading to reduced basal and stimulated gastric acid secretion. The combination aims to improve symptoms of acid reflux and dyspepsia by both reducing acid and promoting forward movement of stomach contents.
Mechanism Steps
💡 How to Take combidom tablet
Strength: Each tablet contains domperidone 10 mg and ranitidine 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally one to two times daily, preferably before meals. The exact dose and duration depend on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and extrapyramidal symptoms. Dose adjustment may be necessary based on renal and hepatic function. Consult a doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, the ranitidine component may require dose reduction. For creatinine clearance less than 50 mL/min, a lower dose or longer dosing interval may be advised. Consult a doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, domperidone metabolism may be reduced, increasing the risk of side effects. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (domperidone 20 mg and ranitidine 300 mg) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of combidom tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Atazanavir | Major | |
| Metoclopramide | Moderate | |
| Erythromycin | Moderate | |
| Antacids | Minor | |
| Sucralfate | Minor | |
| Atropine | Moderate | |
| Clarithromycin | Major | |
| Ritonavir | Major |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin
- Warfarin
- Atazanavir, ritonavir
⚡ Moderate Interactions
- Metoclopramide
- Anticholinergic drugs (e.g., atropine)
- CYP3A4 inhibitors (e.g., erythromycin)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase stomach acid production, worsen reflux symptoms, and add to central nervous system effects such as dizziness and drowsiness. It may also increase the risk of gastrointestinal irritation.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone or ranitidine","Prolonged QT interval or history of ventricular arrhythmias","Severe hepatic impairment","Severe renal impairment (creatinine clearance < 30 mL/min) for ranitidine component","Concurrent use with potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)","Prolactin-releasing pituitary tumor (prolactinoma)","Gastrointestinal obstruction, perforation, or bleeding"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of side effects.","Avoid in patients with Parkinson's disease as domperidone may worsen symptoms.","Monitor for signs of extrapyramidal reactions, especially in children and elderly.","Do not exceed recommended dose or duration; risk of cardiac arrhythmias.","Use with caution in patients with electrolyte imbalances (hypokalemia, hypomagnesemia).","Ranitidine may mask symptoms of gastric malignancy; evaluate if symptoms persist.","Avoid concurrent use with alcohol or other CNS depressants."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Ranitidine is also excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose may cause drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be considered if ingestion is recent. Monitor ECG and vital signs. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can worsen stomach irritation and increase drowsiness. Inform your doctor if you have heart, liver, or kidney problems, or if you are taking other medications, especially blood thinners, antifungals, or certain antibiotics. Do not use this medicine for longer than 14 days without medical advice. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before use.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of cardiac arrhythmias, extrapyramidal symptoms, and drug interactions. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed and under medical supervision.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your surgeon. It may affect gastric motility and could interact with other postoperative medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with certain anesthetics or medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness. Moderate activities like walking are generally safe. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it before meals and plan your work schedule accordingly.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience serious side effects such as irregular heartbeat, muscle spasms, or allergic reactions. Do not stop abruptly without consulting your doctor if you have been on long-term therapy. Always follow your doctor's advice regarding duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to potential risks of cardiac arrhythmias, extrapyramidal symptoms, and hormonal effects such as breast tenderness. Regular monitoring of heart rhythm, liver and kidney function may be required if used for extended periods. Consult your doctor for alternative treatments if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet changes, weight loss, and avoiding trigger foods can help manage acid reflux.
Evidence: Well-establishedMedications like omeprazole or pantoprazole may be prescribed as alternatives for stronger acid suppression.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If traveling across time zones, adjust dosing times gradually under medical guidance. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after taking it. You may notice relief from heartburn and nausea within the first few doses.
A: It can interact with several drugs, including ketoconazole, warfarin, and certain antibiotics. Always inform your doctor about all medicines you are taking.
A: It is generally prescribed for short-term use, up to 14 days. Prolonged use should only be under medical supervision.
🤔 Common Patient Concerns
🔄 Substitutes for combidom tablet
View AllAlternative brands with exact same active ingredient:
-
randex 10 mg/150 mg tabletZee Laboratories ₹1.98 91.6% CHEAPER
-
reloc dm 10 mg/150 mg tabletReddy Pharmaceuticals ₹4.45 81% CHEAPER
-
raninec dm 10mg/150mg tabletNectar Biopharma Pvt Limited ₹5.20 77.8% CHEAPER
-
ranloc dm tabletIntas Pharmaceuticals Ltd ₹5.26 77.6% CHEAPER
-
zynol dm 10 mg/150 mg tabletMicro Labs Ltd ₹5.26 77.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken indefinitely for acid reflux.
Fact: It is intended for short-term use, usually up to 14 days, unless otherwise directed by a doctor. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain heart, liver, or kidney conditions, and should be used only under medical supervision. - Myth: Taking a double dose will provide faster relief.
Fact: Doubling the dose can increase the risk of serious side effects and is not recommended.
🔄 Alternative Options
Generic Alternatives
- Domperidone 10 mg + Ranitidine 150 mg tablet (generic)