Afra Z Syrup: Complete Guide to Uses, Dosage, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Vomiting blood or material that looks like coffee grounds
- Black, tarry stools or blood in the stool
- Severe or worsening abdominal pain
- Difficulty breathing or swelling of the face, lips, or throat
- Chest pain or pressure that spreads to the arm or jaw
- Yellowing of the skin or eyes
- Confusion, muscle weakness, or irregular heartbeat
- Decreased urine output or swelling of the legs
If experiencing severe symptoms, call emergency services immediately.
What is com-mps syrup used for?
This medicine is an oral antacid and antiflatulent syrup containing magaldrate and simethicone. It neutralises stomach acid and helps relieve trapped gas, providing short-term relief from heartburn, indigestion, and bloating. It is usually taken after meals and at bedtime, and should not be used for more than two weeks without medical advice.
- Generic Name: Magaldrate + Simethicone
- Manufacturer: Zentis Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 com-mps syrup के बारे में (Hindi Summary)
उपयोग: यह दवा मैगल्ड्रेट और सिमेथिकोन का मिश्रण है, जो सिरप के रूप में मिलती है। यह पेट की अम्लता, सीने में जलन, खट्टी डकार, अपच और पेट में गैस या भारीपन से राहत दिलाने के लिए इस्तेमाल की जाती है। मैगल्ड्रेट पेट के एसिड को बेअसर करता है और सिमेथिकोन गैस के बुलबुले तोड़कर उन्हें बाहर निकालने में मदद करता है। यह दवा खाने के बाद और रात को सोने से पहले ली जा सकती है। इसे दो हफ्तों से ज्यादा बिना डॉक्टर की सलाह के नहीं लेना चाहिए। गुर्दे की गंभीर बीमारी वाले लोगों को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: आमतौर पर यह दवा सही मात्रा में लेने पर अच्छी तरह सहन की जाती है। कुछ लोगों को हल्का दस्त, कब्ज, जी मिचलाना, पेट में ऐंठन या मुँह में चॉक जैसा स्वाद महसूस हो सकता है। ये लक्षण आमतौर पर अपने आप ठीक हो जाते हैं। लंबे समय तक या ज्यादा मात्रा में लेने से शरीर में मैग्नीशियम और एल्युमिनियम की मात्रा बढ़ सकती है, खासकर गुर्दे की बीमारी वाले लोगों में। अगर साँस लेने में तकलीफ, चेहरे या गले में सूजन, गंभीर पेट दर्द, काला मल या उल्टी में खून दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर या लेबल पर लिखी मात्रा के अनुसार ही लें। हर बार लेने से पहले बोतल को अच्छी तरह हिलाएँ और साथ दिए गए चम्मच या कप से मात्रा नापें। दूसरी दवाओं के साथ लेने से पहले कम से कम दो घंटे का अंतर रखें, क्योंकि यह दवा उनके असर को कम कर सकती है। गुर्दे की बीमारी, हृदय की समस्या या मैग्नीशियम-एल्युमिनियम कम लेने वाले आहार पर हैं तो डॉक्टर से पूछें। दो हफ्तों से ज्यादा बिना सलाह के न लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें। बच्चों की पहुँच से दूर रखें।
💊 com-mps syrup Uses & Benefits
[{"condition":"Heartburn and acid indigestion","description":"Provides rapid neutralisation of gastric acid to relieve burning discomfort behind the breastbone and in the upper abdomen.","evidence":"Well-established"},{"condition":"Gastro-oesophageal reflux symptoms","description":"Reduces acid exposure in the lower oesophagus and eases regurgitation-related burning after meals.","evidence":"Well-established"},{"condition":"Functional dyspepsia with bloating","description":"Combines acid neutralisation with antifoaming action to reduce upper abdominal fullness and gas-related discomfort.","evidence":"Moderate"},{"condition":"Post-operative gas and bloating","description":"Simethicone helps relieve retained gas after abdominal surgery when prescribed by the treating team.","evidence":"Limited"},{"condition":"Antacid cover for NSAID-related dyspepsia","description":"May be used for short-term symptom relief in people taking non-steroidal anti-inflammatory drugs who develop mild indigestion.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Preparation before upper GI endoscopy","description":"Simethicone-containing antacids are sometimes used to reduce foam and bubbles in the stomach before endoscopic examination.","evidence":"Limited"},{"condition":"Colic in infants","description":"Simethicone has been used off-label for infantile colic, but evidence of benefit is inconsistent and it should only be given under paediatric advice.","evidence":"Limited"}]
Primary treatment for: Acid indigestion and heartburn
Also treats: Gastro-oesophageal reflux disease, Functional dyspepsia, Gastritis, Bloating and flatulence
📋 Drug Information
| Generic Name(s) | Magaldrate + Simethicone |
| Brand Name | Aciloc-S Suspension Sugar Free |
| Manufacturer | Zentis Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antacid + Antiflatulent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep the bottle tightly closed when not in use. |
| Shelf Life | Typically 24 months from the date of manufacture, or as printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Magaldrate is a complex of magnesium and aluminium hydroxides that reacts with hydrochloric acid in the stomach to form water and neutral salts, raising gastric pH and reducing the irritant effect of acid on the oesophageal and gastric mucosa. Simethicone is a polydimethylsiloxane with low surface tension; it spreads over the surface of gas bubbles in the gastrointestinal tract, weakens the bubble film, and allows smaller bubbles to coalesce and be expelled by belching or passing flatus. Together they provide both acid neutralisation and gas relief without systemic acid suppression.
Mechanism Steps
💡 How to Take com-mps syrup
Strength: Each 5 ml of syrup contains magaldrate 400 mg and simethicone 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 to 10 ml taken orally three to four times a day, preferably 20 to 60 minutes after meals and at bedtime, or as needed for symptoms. Shake the bottle well before measuring. The exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Do not exceed the maximum daily dose stated on the label. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the constipating effects of aluminium-containing antacids and to electrolyte disturbances. Use the lowest effective dose for the shortest duration, and consult a doctor if symptoms persist. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine should be avoided in severe renal impairment because magnesium and aluminium can accumulate. In mild to moderate renal impairment, use only under medical supervision and for the shortest possible time. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is required in liver disease because this medicine is not metabolised by the liver. However, any underlying liver condition should be discussed with your doctor before use. |
| Maximum Daily Dose | The maximum daily dose depends on the product label and the clinical situation. Do not exceed the dose recommended by your doctor or the package insert. For self-medication, the usual limit is four doses in 24 hours for no more than two weeks. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of com-mps syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tetracycline | Major | |
| Ciprofloxacin | Major | |
| Levothyroxine | Major | |
| Iron salts | Major | |
| Digoxin | Moderate | |
| Ketoconazole | Moderate | |
| Bisphosphonates | Moderate | |
| Paracetamol | Minor | |
| Aspirin | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Tetracycline antibiotics
- Fluoroquinolone antibiotics
- Iron salts
- Levothyroxine
⚡ Moderate Interactions
- Digoxin
- Ketoconazole and itraconazole
- Bisphosphonates
- Sodium polystyrene sulfonate
🍷 Alcohol Interaction
Alcohol can irritate the stomach lining and worsen heartburn and gastritis, which may make this medicine seem less effective. It is advisable to avoid or limit alcohol while you are being treated for acid-related symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to magaldrate, simethicone, or any component of the syrup","Severe renal impairment or chronic kidney disease with electrolyte disturbance","Suspected or confirmed gastrointestinal obstruction or perforation","Severe abdominal pain of unknown cause","Hypophosphataemia or magnesium-restricted diets","Children under 12 years unless specifically advised by a paediatrician"]
⚠️ Warnings & Precautions
["Do not use this medicine for more than two weeks without medical advice.","Avoid taking other oral medicines within two hours of this medicine because absorption may be reduced.","Use with caution in elderly patients, who are more prone to constipation and electrolyte problems.","Patients on a low-magnesium or low-aluminium diet should consult their doctor before use.","Do not exceed the recommended dose, as this increases the risk of side effects.","If symptoms persist or worsen after seven days, stop the medicine and consult a doctor.","Keep out of reach of children and do not use after the expiry date."]
🤱 Lactation Safety
Magaldrate and simethicone are not expected to pass into breast milk in clinically significant amounts because they act locally in the gut and are poorly absorbed. Short-term use is generally considered compatible with breastfeeding, but consult your doctor or pharmacist before use.
💊 Overdose Management
Overdose with this medicine can cause diarrhoea, abdominal pain, and electrolyte imbalance. In severe cases, especially in people with kidney disease, magnesium or aluminium accumulation may occur. Treatment is supportive and symptomatic. Do not induce vomiting. Seek immediate medical attention or contact a poison control centre if a large amount has been taken, and take the bottle or packaging with you to the hospital.
⏰ Missed Dose
This medicine is usually taken when needed for symptoms rather than on a fixed schedule. If you are taking it regularly and miss a dose, take it as soon as you remember, unless it is almost time for the next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as directed on the label or by your doctor, and shake the bottle well before each use. Measure the dose with the spoon or cup provided, not with a household spoon. Do not take more than the recommended dose or use it for longer than two weeks without medical advice. Avoid taking this medicine within two hours of other oral medicines, because it can reduce their absorption. If you have kidney disease, heart failure, or are on a magnesium- or aluminium-restricted diet, speak to your doctor before using this product. Do not use it if you are allergic to magaldrate, simethicone, or any ingredient in the syrup. Keep it out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Stop the medicine and seek medical help if you develop severe abdominal pain, black stools, vomiting of blood, or signs of an allergic reaction.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to constipation from aluminium-containing antacids and to electrolyte disturbances from magnesium accumulation. Use the lowest effective dose for the shortest duration, ensure adequate fluid intake, and consult a doctor if symptoms persist or if you have kidney disease.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive or are in early pregnancy, consult your doctor before using this medicine. Short-term use may be considered acceptable, but prolonged or high-dose use should be avoided. Lifestyle measures for heartburn should be tried first.
🏥 Post-Surgery Considerations
After surgery, especially abdominal surgery, this medicine may be used for gas and bloating only if advised by the treating surgeon. Do not self-medicate after surgery, because some symptoms may require urgent evaluation.
🦷 Dental Procedures
This medicine does not usually interfere with dental procedures. However, if you are taking other medicines for pain or infection, inform your dentist about all medicines you take, as antacids can reduce the absorption of some antibiotics and painkillers.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There is no restriction on exercise while taking this medicine. However, avoid vigorous exercise immediately after a heavy meal, as it can worsen reflux and bloating. Gentle walking after meals may help digestion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine does not usually cause drowsiness or impair concentration, so it is unlikely to affect driving or operating machinery. However, if you feel unwell or dizzy for any reason, avoid driving until you feel better. It can be taken at work after meals, but plan a two-hour gap before other medicines.
🛑 When to Stop This Medicine
Stop this medicine if your symptoms improve and you no longer need it. Do not continue it for more than two weeks without medical advice. Stop immediately and seek medical help if you develop severe abdominal pain, black stools, vomiting of blood, or signs of an allergic reaction. If symptoms persist or recur frequently, consult a doctor before restarting.
📅 Long-Term Use Effects
Long-term or excessive use of this medicine can lead to electrolyte disturbances, particularly high magnesium or aluminium levels, especially in people with kidney disease. It may also cause persistent constipation or diarrhoea and can mask more serious conditions such as peptic ulcer or oesophageal disease. Prolonged use should be reviewed by a doctor, and monitoring of renal function and electrolytes may be needed in at-risk patients.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Smaller meals, avoiding trigger foods, and not lying down after meals can reduce acid symptoms.
Evidence: Well-establishedLosing excess weight reduces abdominal pressure and can improve reflux symptoms.
Evidence: Well-establishedRaising the head of the bed helps prevent night-time acid reflux.
Evidence: ModerateRelaxation techniques may reduce stress-related dyspepsia.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate or freeze the syrup
✅ DO
Keep the bottle tightly closed in its original carton
❌ DON'T
Do not transfer the syrup to an unmarked container
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store near a stove or in a hot car
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original bottle with the label intact, and keep a copy of your prescription if it was prescribed. Store it in hand luggage at room temperature and protect it from direct sunlight and extreme heat. If you are crossing time zones and take this medicine on a fixed schedule, adjust doses gradually to the new meal times. Check the customs rules of your destination for liquid medicines, and carry only the amount needed for your trip. Do not transfer the syrup to an unmarked container.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts neutralising acid within a few minutes of taking it, and the antiflatulent effect usually begins within 10 to 30 minutes.
A: It is intended for short-term use, usually no more than two weeks without medical advice. If symptoms persist, consult a doctor.
A: It can reduce the absorption of several medicines, so keep a gap of at least two hours between this medicine and other oral drugs.
A: Short-term use may be acceptable under medical advice, but you should consult your doctor before taking it during pregnancy.
A: Pediatric dosing is not established from available information. Consult a pediatrician before giving it to a child.
A: If you are on a regular schedule, take the missed dose as soon as you remember unless it is almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for com-mps syrup
View AllAlternative brands with exact same active ingredient:
-
stayhappi magaldrate+simethicone 400mg/20mg oral suspensionSarvagunaushdhi Pvt Ltd ₹34.89 16.9% CHEAPER
-
wisfast suspensionWisdom Pharma Pvt. Ltd ₹35.85 14.6% CHEAPER
-
acixx syrup saunfMark Remedies Pvt Ltd ₹35.88 14.6% CHEAPER
-
madarat-s oral suspensionSanify Healthcare Pvt Ltd ₹36.56 13% CHEAPER
-
acixx syrup pineappleMark Remedies Pvt Ltd ₹38.27 8.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken indefinitely for acidity.
Fact: It is intended for short-term relief only. Prolonged use can cause electrolyte problems and mask more serious conditions. - Myth: Antacids can be taken at the same time as all other medicines.
Fact: This medicine can reduce the absorption of many drugs, so other oral medicines should be taken at least two hours apart. - Myth: More syrup means faster relief.
Fact: Taking more than the recommended dose does not improve relief and increases the risk of side effects such as diarrhoea or constipation. - Myth: This medicine is safe for everyone with kidney disease.
Fact: People with severe kidney disease should avoid this medicine because magnesium and aluminium can accumulate in the body.
🔄 Alternative Options
Generic Alternatives
- Magaldrate 400 mg + Simethicone 20 mg per 5 ml oral suspension
- Magaldrate and simethicone oral gel
- Magaldrate and simethicone chewable tablets