Almefkem Spas 10mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is colinol spas 10 mg/250 mg tablet used for?
This medicine is a combination of dicyclomine (10 mg) and mefenamic acid (250 mg) used to relieve abdominal cramps and pain associated with irritable bowel syndrome and menstrual cramps. It works by relaxing gastrointestinal smooth muscle and reducing inflammation. Take it with food, and avoid alcohol.
- Generic Name: Dicyclomine + Mefenamic Acid
- Manufacturer: Noel Pharma India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 colinol spas 10 mg/250 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेट की ऐंठन, इरिटेबल बाउल सिंड्रोम (IBS) और मासिक धर्म के दर्द में राहत के लिए इस्तेमाल की जाती है। इसमें डाइसाइक्लोमिन और मेफेनैमिक एसिड होते हैं जो पेट की मांसपेशियों को आराम देते हैं और दर्द व सूजन को कम करते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, चक्कर आना, नींद आना, जी मिचलाना, पेट दर्द और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या या एलर्जी हो सकती है। यदि काला मल, खून की उल्टी, तेज पेट दर्द या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। यदि आपको चक्कर या नींद आती है तो वाहन न चलाएँ। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। 7 दिन से अधिक इस दवा का सेवन बिना डॉक्टर की सलाह के न करें।
💊 colinol spas 10 mg/250 mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal cramps and pain associated with IBS by reducing smooth muscle spasms and inflammation.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Reduces menstrual cramps and pelvic pain by inhibiting prostaglandin production and relaxing uterine smooth muscle.","evidence":"Well-established"},{"condition":"Gastrointestinal spasm","description":"Provides relief from spasms in the stomach and intestines due to various causes.","evidence":"Established"},{"condition":"Biliary colic","description":"May be used to relieve pain from gallbladder spasms, though definitive evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Urinary tract spasms","description":"Sometimes prescribed off-label to relieve bladder spasms, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome (IBS) and primary dysmenorrhea.
Also treats: Gastrointestinal spasm, Biliary colic, Urinary tract spasms (off-label)
📋 Drug Information
| Generic Name(s) | Dicyclomine + Mefenamic Acid |
| Brand Name | Almefkem Spas 10mg/250mg Tablet |
| Manufacturer | Noel Pharma India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Antispasmodic + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Dicyclomine is an anticholinergic and antispasmodic agent that blocks muscarinic acetylcholine receptors in the gastrointestinal smooth muscle, reducing muscle contractions and spasms. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), decreasing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Together, they provide relief from both spasm and pain.
Mechanism Steps
💡 How to Take colinol spas 10 mg/250 mg tablet
Strength: Each tablet contains dicyclomine hydrochloride 10 mg and mefenamic acid 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably with food. The maximum recommended dose is not to exceed 4 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic effects of dicyclomine and the renal effects of mefenamic acid. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Dose adjustment may be necessary based on renal function. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Avoid in severe hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 tablets (40 mg dicyclomine and 1000 mg mefenamic acid) in divided doses. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of colinol spas 10 mg/250 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| ACE inhibitors | Moderate | |
| ARBs | Moderate | |
| Anticholinergics | Moderate | |
| Antacids | Minor | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Anticholinergic drugs (e.g., atropine, antihistamines)
⚡ Moderate Interactions
- Lithium
- Methotrexate
- ACE inhibitors and ARBs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may enhance central nervous system effects such as drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to dicyclomine, mefenamic acid, or any component of the formulation.","Active peptic ulcer disease or history of recurrent ulcers.","Severe renal impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of anticholinergic effects and renal impairment.","Avoid in patients with cardiovascular disease or risk factors due to NSAID-related cardiovascular risk.","Do not use for prolonged periods without medical supervision.","May cause drowsiness; avoid driving or operating machinery until effects are known.","May worsen symptoms of gastroesophageal reflux disease (GERD).","Use with caution in patients with asthma, as NSAIDs may precipitate bronchospasm.","May mask signs of infection by reducing fever and inflammation."]
🤱 Lactation Safety
Dicyclomine is excreted in human milk and may cause anticholinergic effects in the infant. Mefenamic acid is also excreted in breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe anticholinergic symptoms (e.g., dry mouth, flushing, tachycardia, urinary retention, confusion) and NSAID toxicity (e.g., nausea, vomiting, gastrointestinal bleeding, renal failure). Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be considered if presented early. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not take this medicine for more than 7 days without medical advice. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic effects of dicyclomine (e.g., confusion, dry mouth, urinary retention) and the renal effects of mefenamic acid. Use with caution and consider lower doses. Regular monitoring of renal function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally avoided during pregnancy, especially in the third trimester, due to potential risks to the fetus.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as NSAIDs can increase the risk of bleeding and may interfere with healing.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy. Light activities like walking may be beneficial, but consult your doctor before starting any exercise routine while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or if your symptoms do not improve within 7 days. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, and cardiovascular events. It is not recommended for prolonged use without medical supervision. Regular monitoring of renal and hepatic function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle function.
Evidence: Well-establishedAvoiding trigger foods can reduce IBS symptoms.
Evidence: EstablishedYoga, meditation, and counseling can help reduce stress-related abdominal cramps.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Keep it in your carry-on luggage to avoid loss. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antispasmodic effect may begin within 30 to 60 minutes, and pain relief typically starts within 1 to 2 hours after taking this medicine.
A: It is best taken with food or milk to reduce the risk of stomach upset and gastrointestinal irritation.
A: Consult your doctor before taking this medicine during pregnancy. It is generally avoided in the third trimester due to potential risks to the fetus.
A: Do not take other NSAIDs (like ibuprofen or aspirin) without consulting your doctor, as it may increase the risk of gastrointestinal bleeding.
🤔 Common Patient Concerns
🔄 Substitutes for colinol spas 10 mg/250 mg tablet
View AllAlternative brands with exact same active ingredient:
-
swispas m 10 mg/250 mg tabletInd Swift Laboratories Ltd ₹4.69 88.1% CHEAPER
-
mefcon spas tabletConcept Pharmaceuticals Ltd ₹4.98 87.4% CHEAPER
-
spasmover tabletCachet Pharmaceuticals Pvt Ltd ₹5.00 87.3% CHEAPER
-
mefemin 10 mg/250 mg tabletTroikaa Pharmaceuticals Ltd ₹5.58 85.9% CHEAPER
-
anglospas 10 mg/250 mg tabletAnglo-French Drugs & Industries Ltd ₹5.86 85.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for abdominal cramps and menstrual pain. It is not a general painkiller for headaches or muscle aches. - Myth: It is safe to take this medicine for long periods without a doctor's supervision.
Fact: Long-term use can increase the risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. It should only be used short-term unless prescribed by a doctor. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal irritation.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine + Mefenamic Acid combination (generic)
Brand Alternatives
- Almefkem Spas 10mg/250mg Tablet