Coldargic Drop: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache with blurred vision or confusion
- Chest pain or irregular heartbeat
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Blood in vomit or stool
- Sudden severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is coldargic drop used for?
This medicine is a combination of Paracetamol and Phenylpropanolamine used for short-term relief of nasal congestion, fever, and pain associated with colds. However, due to safety concerns with Phenylpropanolamine, it should only be used under medical supervision.
- Generic Name: Paracetamol + Phenylpropanolamine
- Manufacturer: Nodysis Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 coldargic drop के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल और फेनिलप्रोपेनॉलामाइन का संयोजन है, जिसका उपयोग सर्दी-जुकाम में नाक बंद होने, बुखार और दर्द से राहत के लिए किया जाता है। यह केवल अल्पकालिक उपयोग के लिए है और डॉक्टर की सलाह के बिना न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, मुँह सूखना, चक्कर आना, बेचैनी और सिरदर्द शामिल हैं। कभी-कभी हृदय गति बढ़ सकती है या रक्तचाप बढ़ सकता है। गंभीर दुष्प्रभाव जैसे एलर्जी, हृदय संबंधी समस्याएं या यकृत की क्षति दुर्लभ हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग केवल डॉक्टर के निर्देशानुसार करें। निर्धारित मात्रा से अधिक न लें। अन्य पैरासिटामोल युक्त दवाओं के साथ न लें। उच्च रक्तचाप या हृदय रोग होने पर सावधानी बरतें। शराब का सेवन न करें। गाड़ी चलाते समय सावधानी रखें। बच्चों की पहुंच से दूर रखें।
💊 coldargic drop Uses & Benefits
[{"condition":"Common cold with nasal congestion","description":"Provides temporary relief of nasal stuffiness and associated headache or fever.","evidence":"Established for short-term symptomatic relief"},{"condition":"Allergic rhinitis with congestion","description":"Helps reduce nasal blockage and discomfort, though antihistamines are often preferred.","evidence":"Limited, short-term use only"},{"condition":"Sinusitis with congestion","description":"May ease nasal congestion and pain as part of supportive care.","evidence":"Supportive, not a substitute for antibiotics when indicated"},{"condition":"Fever with upper respiratory symptoms","description":"Paracetamol component reduces fever while Phenylpropanolamine addresses congestion.","evidence":"Established for symptom relief"}]
Off-label uses: [{"condition":"Weight loss (historical)","description":"Phenylpropanolamine was formerly used as an appetite suppressant but is no longer recommended due to safety concerns.","evidence":"Not recommended; withdrawn in many countries"}]
Primary treatment for: Common cold
Also treats: Allergic rhinitis, Sinusitis, Upper respiratory tract infections
📋 Drug Information
| Generic Name(s) | Paracetamol + Phenylpropanolamine |
| Brand Name | Anglocet Plus Tablet |
| Manufacturer | Nodysis Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Analgesic, Antipyretic, Decongestant |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the container tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which raises the pain threshold and lowers fever through effects on the hypothalamic heat-regulating center. Phenylpropanolamine is a mixed-acting sympathomimetic amine that both releases norepinephrine from nerve endings and directly stimulates alpha-adrenergic receptors, causing vasoconstriction of nasal mucosal blood vessels and reduced swelling. This dual action relieves nasal congestion. The combination does not treat the underlying infection but provides symptomatic relief.
Mechanism Steps
💡 How to Take coldargic drop
Strength: Each dose unit (drop) contains Paracetamol 125 mg and Phenylpropanolamine 12.5 mg.
Dosage Information
| Adult Dosage | The adult dose of this medicine is individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Typically, it is taken every 4 to 6 hours as needed for symptoms, but the exact dose and frequency must be determined by your doctor. Do not exceed the maximum daily dose. Follow your doctor's instructions carefully. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiovascular effects of Phenylpropanolamine and to the central nervous system effects of Paracetamol. Use with caution and under medical supervision. Dose adjustment may be necessary based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose of Paracetamol should not exceed 4 grams (4000 mg) for adults, and the Phenylpropanolamine content should not exceed 150 mg per day. However, the exact maximum daily dose for this specific combination product must be determined by a qualified clinician based on the patient's condition and other factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of coldargic drop
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Warfarin | Major | |
| Beta-blockers | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Caffeine | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| Other sympathomimetics | Major | |
| Digoxin | Moderate | |
| Ergot alkaloids | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other sympathomimetics (e.g., pseudoephedrine, ephedrine)
- Warfarin
⚡ Moderate Interactions
- Beta-blockers
- Tricyclic antidepressants
- Caffeine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of Paracetamol-induced liver injury and may worsen cardiovascular effects of Phenylpropanolamine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Paracetamol, Phenylpropanolamine, or any component","Uncontrolled hypertension","Severe coronary artery disease","Hyperthyroidism","Closed-angle glaucoma","Concurrent use of MAOIs or within 14 days of stopping MAOIs","Severe liver disease","Pregnancy (especially first trimester) and breastfeeding"]
⚠️ Warnings & Precautions
["Use with caution in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders.","Do not exceed recommended dose or duration.","Avoid alcohol.","May cause dizziness; avoid driving or operating machinery until effects are known.","Consult a doctor if symptoms persist beyond 5 days or worsen.","Keep out of reach of children.","Do not use in children under 2 years without medical advice."]
🤱 Lactation Safety
Paracetamol is considered compatible with breastfeeding. Phenylpropanolamine may pass into breast milk and could cause stimulation or other effects in the infant. Avoid using this combination while breastfeeding unless advised by a doctor.
💊 Overdose Management
Overdose of Paracetamol can cause severe liver damage, which may be delayed. Symptoms of Paracetamol overdose include nausea, vomiting, abdominal pain, and later signs of liver failure. Phenylpropanolamine overdose can cause severe hypertension, tachycardia, and arrhythmias. If overdose is suspected, seek emergency medical care immediately. Treatment may include activated charcoal, N-acetylcysteine for Paracetamol toxicity, and supportive care for cardiovascular effects.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Use this medicine only as directed by a qualified clinician. Do not exceed the recommended dose or duration. Avoid taking other products that contain Paracetamol to prevent accidental overdose. Check your blood pressure regularly if you have hypertension or are at risk. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Avoid alcohol completely while taking this medicine because it increases the risk of liver damage. Inform your doctor about all other medicines, especially blood pressure drugs, antidepressants, and blood thinners. Keep this medicine out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the cardiovascular effects of Phenylpropanolamine and the central nervous system effects of Paracetamol. Use with caution and monitor blood pressure and heart rate. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. Phenylpropanolamine is not recommended during pregnancy. Paracetamol may be used if clearly needed, but only under medical advice.
🏥 Post-Surgery Considerations
Consult your surgeon before using this medicine after surgery, as it may interact with other medications or affect blood pressure. Paracetamol may be used for pain if approved, but Phenylpropanolamine should be avoided due to cardiovascular effects.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Phenylpropanolamine can interact with local anesthetics containing epinephrine, potentially causing cardiovascular effects.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you experience dizziness, palpitations, or increased blood pressure. Light activity may be fine if you feel well, but consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or restlessness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to rest and recover rather than push through work if you are unwell.
🛑 When to Stop This Medicine
Stop taking this medicine if your symptoms improve or after the recommended duration (usually not more than 5 days). If symptoms persist or worsen, consult your doctor. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of Paracetamol can increase the risk of liver damage, especially with high doses or alcohol consumption. Phenylpropanolamine can cause cardiovascular complications such as hypertension and arrhythmias. Regular monitoring of blood pressure and liver function may be necessary if used for extended periods under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Help relieve nasal congestion without systemic side effects.
Evidence: Well-establishedCan temporarily ease nasal stuffiness.
Evidence: Commonly used, limited evidenceMay help if congestion is due to allergies.
Evidence: Well-established for allergic rhinitis💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing intervals as advised by your doctor. Check local regulations regarding Phenylpropanolamine, as it may be restricted in some countries.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Paracetamol starts relieving fever and pain within 30-60 minutes, while Phenylpropanolamine reduces nasal congestion within 15-30 minutes.
A: Yes, taking it with food can reduce stomach upset.
A: Pediatric dosing is not established. Consult a pediatrician before giving this medicine to children.
A: Take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for coldargic drop
View AllAlternative brands with exact same active ingredient:
-
wincold 125 mg/12.5 mg/1 mg tabletWings Biotech Ltd ₹7.50 64.3% CHEAPER
-
vicosyl p syrupVostok & Wilcure Remedies ₹15.84 24.6% CHEAPER
-
lamogin syrupBrussels Laboratories Pvt Ltd ₹16.88 19.6% CHEAPER
-
pro kid syrupShiwalic Formulations Pvt Ltd ₹19.80 5.7% CHEAPER
-
wincold syrupWings Biotech Ltd ₹20.00 4.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Coldargic drop is safe for everyone.
Fact: It is not safe for people with high blood pressure, heart disease, or those taking certain medications. - Myth: It can be used for long periods.
Fact: It should only be used for short-term relief, typically not more than 5 days. - Myth: It is a cure for the common cold.
Fact: It only relieves symptoms; it does not cure the underlying viral infection.
🔄 Alternative Options
Generic Alternatives
- Paracetamol + Phenylpropanolamine generic drops (if available)