Azirest Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Irregular heartbeat or palpitations
- Confusion or hallucinations
If experiencing severe symptoms, call emergency services immediately.
What is cold off tablet used for?
This medicine is a combination of caffeine and chlorpheniramine maleate used to treat allergic rhinitis and common cold symptoms. It works by blocking histamine and providing mild stimulation to counteract drowsiness.
- Generic Name: Caffeine + Chlorpheniramine Maleate
- Manufacturer: Stadmed Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cold off tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी राइनाइटिस, सर्दी-जुकाम और अन्य एलर्जी के लक्षणों जैसे छींक, नाक बहना, आंखों में खुजली और पानी आना में राहत देती है। इसमें कैफीन और क्लोरफेनिरामाइन मेलिएट होता है, जो एलर्जी को कम करने और नींद को कम करने में मदद करता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, धुंधली दृष्टि, मतली और बेचैनी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, अनियमित दिल की धड़कन, भ्रम या पेशाब में रुकावट हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 cold off tablet Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief from sneezing, runny nose, and watery eyes associated with the common cold.","evidence":"Well-established"},{"condition":"Urticaria","description":"Helps reduce itching and hives associated with allergic skin reactions.","evidence":"Moderate"},{"condition":"Allergic conjunctivitis","description":"Reduces itching, redness, and tearing of the eyes due to allergies.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Insomnia due to allergies","description":"Sometimes used off-label for its sedative effects to help with sleep in patients with allergic symptoms, but this is not a recommended use.","evidence":"Limited"},{"condition":"Motion sickness","description":"Chlorpheniramine may help with motion sickness due to its anticholinergic properties, but combination with caffeine may not be ideal.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Common cold, Urticaria, Allergic conjunctivitis
📋 Drug Information
| Generic Name(s) | Caffeine + Chlorpheniramine Maleate |
| Brand Name | Almolet Tablet |
| Manufacturer | Stadmed Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + CNS Stimulant |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, thereby preventing histamine-mediated allergic responses such as vasodilation, increased vascular permeability, and sensory nerve stimulation. Caffeine is a central nervous system stimulant that acts as an adenosine receptor antagonist, which increases alertness and can counteract the sedative effects of chlorpheniramine.
Mechanism Steps
💡 How to Take cold off tablet
Strength: Each immediate-release tablet contains caffeine 15 mg and chlorpheniramine maleate 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of chlorpheniramine, especially drowsiness, dizziness, and anticholinergic effects. Use with caution and consider a lower dose. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | The maximum daily dose for adults is 6 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cold off tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Tricyclic antidepressants | Major | |
| CYP2D6 inhibitors | Moderate | |
| CYP1A2 inhibitors | Moderate | |
| Anticholinergics | Moderate | |
| Opioids | Minor | |
| Antihypertensives | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol and other CNS depressants
- Tricyclic antidepressants
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- Anticholinergic drugs (e.g., benztropine, oxybutynin)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of motor skills. The combination can also increase the risk of respiratory depression and other serious adverse effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, caffeine, or any component of the formulation","Narrow-angle glaucoma","Urinary retention","Severe liver disease","Concurrent use with MAOIs","Children under 12 years of age (unless directed by a doctor)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, COPD, or other respiratory conditions.","Use with caution in patients with cardiovascular disease, hypertension, or arrhythmias.","Use with caution in patients with hyperthyroidism, diabetes, or seizure disorders.","Do not use for longer than directed without consulting a doctor.","Keep out of reach of children."]
🤱 Lactation Safety
Chlorpheniramine and caffeine are excreted in breast milk. Chlorpheniramine may cause drowsiness in the nursing infant. Caffeine may cause irritability and poor sleep. Use with caution and consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, seizures, irregular heartbeat, and difficulty breathing. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid consuming alcohol or other central nervous system depressants while taking this medicine, as they can increase drowsiness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine for longer than directed without consulting your doctor. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic and sedative effects of chlorpheniramine. Use with caution and consider a lower dose. Monitor for confusion, urinary retention, and falls.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery.
🦷 Dental Procedures
This medicine may cause dry mouth, which can increase the risk of dental problems. Inform your dentist that you are taking this medicine. It may also interact with sedatives used in dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, which can affect your ability to exercise safely. Avoid strenuous exercise until you know how the medicine affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, which can impact your ability to drive, operate machinery, or perform tasks requiring alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, especially if you have been taking it regularly. If you experience severe side effects, seek medical advice immediately. Your doctor may recommend stopping or adjusting the dose based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance to its stimulant effects and increased risk of side effects such as drowsiness, dry mouth, and urinary retention. It is not recommended for prolonged use without medical supervision. Regular monitoring of liver and kidney function may be advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Reducing exposure to allergens can help manage allergy symptoms.
Evidence: Well-establishedCan help relieve nasal congestion and rinse allergens from the nose.
Evidence: ModerateAllergy shots or sublingual tablets can provide long-term relief for certain allergies.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking it as prescribed, but adjust timing gradually. Check local customs regulations regarding prescription medications before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: Consult your doctor before combining with other antihistamines to avoid additive effects.
A: Consult your doctor; use only if clearly needed.
A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for cold off tablet
View AllAlternative brands with exact same active ingredient:
-
descold tabletSymet Drugs Ltd ₹10.31 24.1% CHEAPER
-
osolate tabletOsho Pharma Pvt Ltd ₹10.31 24.1% CHEAPER
-
kuffery cold tabletZeelab Pharmacy Pvt Ltd ₹11.00 19.1% CHEAPER
-
cosil forte tabletAlpha Drugs & Pharmaceuticals ₹11.25 17.2% CHEAPER
-
harilate tabletPramukh Swami Pharma Ltd ₹13.13 3.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure allergies permanently.
Fact: This medicine only provides symptomatic relief and does not cure allergies. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases drowsiness and other side effects; it should be avoided. - Myth: This medicine is safe for children under 12.
Fact: Safety and effectiveness in children under 12 have not been established; consult a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Caffeine + Chlorpheniramine Maleate tablets
Brand Alternatives
- Azirest Tablet