antispasmin ds 80mg tablet - Drotaverine (80mg) medicine

Drotaverine 80 mg Tablet: Complete Guide to Uses, Side Effects, and Safety

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Drotaverine (80mg)
🏭 Stadmed Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is antispasmin ds 80mg tablet used for?

Drotaverine 80 mg is an antispasmodic medicine used to relieve smooth muscle spasms in conditions like irritable bowel syndrome, biliary colic, and menstrual cramps. It works by relaxing the smooth muscles.

  • Generic Name: Drotaverine
  • Manufacturer: Stadmed Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 antispasmin ds 80mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा ड्रोटावेरिन 80 मिलीग्राम की है, जो पेट, आंत, पित्त नली और गर्भाशय की मांसपेशियों की ऐंठन को कम करने के लिए इस्तेमाल की जाती है। यह चिकित्सक द्वारा बताई गई मात्रा में ही लेनी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, मुँह सूखना, सिरदर्द, चक्कर आना और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या तेज़ धड़कन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अधिक मात्रा में न लें। यदि आपको चक्कर आते हैं तो वाहन चलाने या मशीन चलाने से बचें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब का सेवन न करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 antispasmin ds 80mg tablet Uses & Benefits

[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal cramps and spasms associated with IBS.","evidence":"Well-established"},{"condition":"Biliary colic","description":"Helps relax the smooth muscles of the biliary tract to relieve pain from gallstones.","evidence":"Well-established"},{"condition":"Renal colic","description":"Reduces spasm in the urinary tract, easing pain from kidney stones.","evidence":"Well-established"},{"condition":"Spasmodic dysmenorrhea","description":"Relieves menstrual cramps by relaxing uterine smooth muscle.","evidence":"Well-established"},{"condition":"Gastrointestinal spasm","description":"Used to relieve spasm in various gastrointestinal conditions.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Tension headache","description":"Sometimes used off-label for tension-type headaches, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Smooth muscle spasm

Also treats: Irritable bowel syndrome, Biliary colic, Renal colic, Dysmenorrhea

📋 Drug Information

Generic Name(s)Drotaverine
Brand NameAntispasmin DS 80mg Tablet
ManufacturerStadmed Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassPhosphodiesterase-IV inhibitors (Smooth Muscle Relaxant)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDrotaverine is rapidly absorbed after oral administration. Bioavailability is approximately 25-91% due to first-pass metabolism.
DistributionIt is widely distributed in the body, including smooth muscle tissues. Protein binding is high, approximately 95-98%.
Protein BindingApproximately 95-98% bound to plasma proteins.
MetabolismExtensively metabolized in the liver, primarily by conjugation and oxidation.
Half-LifeApproximately 7-12 hours.
ExcretionMainly excreted in urine as metabolites, with a small amount in feces.
BioavailabilityApproximately 25-91% due to first-pass metabolism.
Onset of ActionOnset of action is typically within 30-60 minutes after oral administration.
Peak Plasma TimePeak plasma concentration is reached in about 1-2 hours.
Duration of ActionThe effect lasts for about 4-8 hours.

How It Works

Drotaverine inhibits phosphodiesterase-4 (PDE4), leading to increased intracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This results in relaxation of smooth muscle by reducing calcium availability and inhibiting contractile processes. It also has some calcium channel blocking activity.

Mechanism Steps

1
Inhibition of PDE4: Drotaverine inhibits the phosphodiesterase-4 enzyme, which normally breaks down cyclic AMP.
2
Increased cAMP: The inhibition leads to higher levels of cyclic AMP inside smooth muscle cells.
3
Reduced calcium: Elevated cAMP reduces the release of calcium from intracellular stores and decreases calcium sensitivity.
4
Smooth muscle relaxation: The reduced calcium availability leads to relaxation of the smooth muscle, relieving spasm and pain.

💡 How to Take antispasmin ds 80mg tablet

Strength: Drotaverine 80 mg immediate-release tablet

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with or without food.
4Follow the prescribed dose and frequency.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 80 mg to 160 mg per day, divided into 2-3 doses. For acute spasms, a single dose of 80 mg may be taken. The maximum daily dose is 240 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required, but use with caution due to increased risk of side effects. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in severe renal impairment. Dose adjustment may be needed. Consult a doctor.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in mild to moderate impairment. Consult a doctor.
Maximum Daily Dose240 mg per day

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of antispasmin ds 80mg tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Dry mouth (Common (1-10%))
Sip water frequently. Usually resolves on its own.
Headache (Common (1-10%))
Rest and stay hydrated. Consult doctor if severe.
Dizziness (Common (1-10%))
Avoid driving or operating machinery until you know how it affects you.
Constipation (Common (1-10%))
Increase fiber and fluid intake. Consult doctor if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling, or difficulty breathing.
Palpitations (Rare (<0.1%))
Consult a doctor if you feel a rapid or irregular heartbeat.
Hypotension (Rare (<0.1%))
If you feel faint or dizzy, lie down and seek medical help.

⚠️ Rare Side Effects

Angioedema
Seek emergency care if swelling of face, lips, or throat occurs.
Bronchospasm
Seek immediate medical attention if breathing difficulty occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Levodopa Major
Antihypertensives Moderate
Antacids Minor

🚨 Major Interactions

  • Levodopa

⚡ Moderate Interactions

  • Antihypertensives
  • Other antispasmodics

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness and drowsiness. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to drotaverine","Severe hepatic impairment","Severe renal impairment","Severe heart failure","Children under 12 years (unless prescribed)"]

⚠️ Warnings & Precautions

["Use with caution in patients with hypotension.","Use with caution in patients with cardiac arrhythmias.","Avoid in patients with severe liver or kidney disease.","May cause dizziness; avoid driving.","Not recommended during pregnancy unless clearly needed."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe hypotension, tachycardia, and CNS depression. Seek immediate medical attention. Treatment is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine only as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery if you feel dizzy after taking it. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medicines you are taking, especially blood thinners, antihypertensives, and other antispasmodics. Avoid alcohol while taking this medicine as it may increase dizziness. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine. Use with caution and monitor for dizziness and low blood pressure.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy if you are taking this medicine. It should be used during pregnancy only if clearly needed.

🏥 Post-Surgery Considerations

Consult your surgeon before taking this medicine after surgery, as it may interact with other medications.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or fatigued. Listen to your body and rest when needed.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use of this medicine should be monitored by a doctor. Periodic liver and kidney function tests may be advised. Do not use for prolonged periods without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Heat therapy

Applying heat to the affected area can help relax muscles.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Consult your doctor for specific advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with severe menstrual cramps
Took this medicine at the onset of cramps and experienced relief within an hour. She now keeps it handy during her periods as advised by her doctor.
💡 Lesson: Taking the medicine early in the spasm cycle can provide faster relief.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after oral administration.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for antispasmin ds 80mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Drotaverine is a general painkiller.
    Fact: Drotaverine is specifically for smooth muscle spasms, not for general pain like headaches or muscle aches.
  • Myth: Drotaverine can be taken long-term without monitoring.
    Fact: Long-term use should be monitored by a doctor, especially liver and kidney function.

🔄 Alternative Options

Generic Alternatives

  • Drotaverine 80 mg tablet

Brand Alternatives

  • Drotin DS
  • Drotin
  • Drotin-M
  • Drotaverine 80 mg

📊 Comparison with Similar Medicines

[{"medicine":"Drotaverine","class":"PDE4 inhibitor","uses":"Smooth muscle spasm","onset":"30-60 min"},{"medicine":"Mebeverine","class":"Antispasmodic","uses":"IBS","onset":"1-2 hours"},{"medicine":"Hyoscine butylbromide","class":"Anticholinergic","uses":"Abdominal cramps","onset":"15-30 min"}]

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