Ambrodil-D Junior Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Seizures or convulsions
- Extreme drowsiness or unresponsiveness
- Fast, irregular, or pounding heartbeat
- Severe dizziness or fainting
- Yellowing of the skin or eyes (jaundice)
- Blood in vomit or stool
- Persistent vomiting or inability to keep fluids down
If experiencing severe symptoms, call emergency services immediately.
What is cofdrex-d syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate (an antihistamine) and dextromethorphan hydrobromide (a cough suppressant). It is used to relieve dry cough and allergic rhinitis symptoms such as sneezing and runny nose in children. It works by blocking histamine and suppressing the cough reflex. It should be used only as prescribed by a doctor.
- Generic Name: Chlorpheniramine Maleate + Dextromethorphan Hydrobromide
- Manufacturer: Mestra Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cofdrex-d syrup के बारे में (Hindi Summary)
उपयोग: यह दवा बच्चों में सूखी खांसी और एलर्जी से होने वाले लक्षणों जैसे छींक, नाक बहना और आंखों में पानी आना के इलाज के लिए दी जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और डेक्सट्रोमेथोर्फन हाइड्रोब्रोमाइड होते हैं। क्लोरफेनिरामाइन एलर्जी को कम करता है और डेक्सट्रोमेथोर्फन खांसी को दबाता है। यह दवा केवल डॉक्टर के परामर्श से ही देनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, जी मिचलाना और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दौरे, सांस लेने में कठिनाई या दिल की धड़कन तेज होना हो सकता है। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग केवल डॉक्टर के बताए अनुसार करें। बच्चों को उम्र से कम पर न दें। अन्य खांसी-जुकाम की दवाओं के साथ न दें। दवा देने के बाद बच्चे को अकेला न छोड़ें। यदि लक्षण 5-7 दिनों से अधिक रहें तो डॉक्टर से मिलें। दवा को ठंडी और सूखी जगह पर रखें।
💊 cofdrex-d syrup Uses & Benefits
[{"condition":"Dry cough associated with common cold","description":"Provides symptomatic relief of non-productive, irritating cough by suppressing the cough reflex.","evidence":"Well-established for short-term use"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, runny nose, itchy and watery eyes, and postnasal drip caused by allergies.","evidence":"Well-established for antihistamine component"},{"condition":"Upper respiratory tract infection with cough and rhinorrhea","description":"Combines cough suppression with antihistamine effects to relieve multiple cold symptoms.","evidence":"Commonly used, though evidence for combination products is moderate"}]
Off-label uses: [{"condition":"Pruritus (itching) due to allergic skin conditions","description":"Antihistamine component may help relieve itching, but this is not a primary indication for the combination.","evidence":"Limited"}]
Primary treatment for: Dry cough and allergic rhinitis
Also treats: Common cold, Upper respiratory tract infection, Allergic conjunctivitis
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate + Dextromethorphan Hydrobromide |
| Brand Name | Alex Junior Syrup |
| Manufacturer | Mestra Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + Antitussive |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed. Use within the expiration date. After opening, use within the period specified on the label, typically within 1-3 months. |
| Shelf Life | Typically 24 months from the date of manufacture. Refer to the product packaging for the exact expiration date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells, reducing vascular permeability, bronchoconstriction, and sensory nerve stimulation that cause sneezing, rhinorrhea, and itching. It also crosses the blood-brain barrier and causes sedation by blocking central H1 receptors. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata. It is a sigma-1 receptor agonist and also inhibits serotonin reuptake, raising the threshold for cough reflex. It does not have analgesic or respiratory depressant effects at therapeutic doses.
Mechanism Steps
💡 How to Take cofdrex-d syrup
Strength: Each 5 mL of syrup contains chlorpheniramine maleate 2 mg and dextromethorphan hydrobromide 10 mg.
Dosage Information
| Adult Dosage | This medicine is formulated as a junior syrup and is primarily intended for pediatric use. For adults, dosing must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Typically, adult dosing for similar combinations may be 10 mL every 4-6 hours as needed, not to exceed 60 mL in 24 hours, but this is for educational reference only. Do not self-medicate; consult a doctor for appropriate adult dosing. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Dosing depends on age, weight, and clinical condition. Do not use in children under the age specified by the prescriber. Use the provided measuring device for accurate dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic and sedative effects of chlorpheniramine. Use with caution and consider dose reduction. Dosing must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be needed. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | For adults, the maximum daily dose of dextromethorphan is typically 120 mg, and chlorpheniramine is 24 mg. For this specific junior syrup, the maximum daily dose must be determined by a qualified clinician based on the child's age and weight. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cofdrex-d syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| CNS depressants | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Moderate | |
| Anticholinergics | Moderate | |
| Opioids | Moderate | |
| Antihypertensives | Minor | |
| Levodopa | Minor | |
| Alcohol | Major | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids, sedatives)
- Selective serotonin reuptake inhibitors (SSRIs)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- Opioid analgesics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and the risk of respiratory depression. The combination can impair motor skills and judgment, making driving or operating machinery dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, dextromethorphan, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs","Children under the age specified by the prescriber (typically under 2 years, but follow specific product labeling)","Productive cough with excessive mucus","Asthma or chronic obstructive pulmonary disease (COPD) unless directed by a doctor","Severe liver disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe hypertension or coronary artery disease"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not use for chronic cough or cough with excessive mucus unless directed by a doctor.","Use with caution in patients with asthma, glaucoma, urinary retention, or cardiovascular disease.","Do not exceed recommended dose; overdose can cause serious adverse effects.","Consult a doctor if symptoms persist beyond 5-7 days or are accompanied by fever, rash, or persistent headache.","Keep out of reach of children; use child-resistant packaging.","Do not use in children under the age recommended by the manufacturer or physician.","May impair mental alertness; supervise children during activities.","Use with caution in elderly patients due to increased sensitivity to anticholinergic effects."]
🤱 Lactation Safety
Chlorpheniramine and dextromethorphan may pass into breast milk. Caution is advised. Consult a doctor before use during breastfeeding. Monitor the infant for drowsiness or poor feeding.
💊 Overdose Management
Overdose can cause severe drowsiness, agitation, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Activated charcoal may be administered. Monitor vital signs, respiratory status, and cardiac rhythm. Naloxone may be used for respiratory depression but is not specific for dextromethorphan. For chlorpheniramine overdose, physostigmine may be considered for severe anticholinergic effects, but use with caution.
⏰ Missed Dose
If a dose is missed, give it as soon as remembered if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Use this medicine only as prescribed by a doctor for a child. Do not exceed the recommended dose or duration. Avoid giving other cough, cold, or antihistamine products at the same time unless advised by a doctor. Do not use in children under the age specified by the prescriber. Keep out of reach of children. Avoid driving or operating machinery if the child feels drowsy. Do not use if the child has asthma, chronic bronchitis, or a productive cough unless directed by a doctor. Consult a doctor if symptoms persist beyond 5-7 days, worsen, or are accompanied by fever, rash, or breathing difficulty. Store at room temperature away from direct sunlight. Do not freeze. Shake well before each use and measure with the provided dosing cup or syringe.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic and sedative effects of chlorpheniramine. They may experience confusion, dry mouth, constipation, and urinary retention. Use with caution and consider lower doses. Consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult a doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination during pregnancy is not well established. Use only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
Consult a doctor before using this medicine after surgery, as it may interact with anesthetics and other medications. It may also increase the risk of respiratory depression. Use only under medical supervision.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental caries. It may also interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Children should avoid strenuous activities or sports if they feel drowsy or dizzy after taking this medicine. Supervise outdoor play and avoid activities requiring alertness, such as cycling or swimming, until the effects wear off.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and impair concentration. Children should not engage in activities requiring mental alertness, such as schoolwork or sports, until they know how the medicine affects them. Adults taking this medicine should avoid driving or operating machinery.
🛑 When to Stop This Medicine
Stop this medicine when the cough and allergy symptoms resolve or as advised by the doctor. Do not use for more than 5-7 days without medical advice. If symptoms persist or worsen, consult a doctor before continuing. Do not stop abruptly if used for a long time without consulting a doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and anticholinergic side effects. Dextromethorphan can cause dependence and withdrawal symptoms with prolonged high-dose use. Regular monitoring of liver and kidney function may be needed if used for extended periods. Consult a doctor if symptoms persist beyond 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help relieve nasal congestion and runny nose without medication.
Evidence: Well-establishedAdds moisture to the air, soothing dry cough and throat irritation.
Evidence: SupportiveFor children over 1 year, honey can help soothe cough.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if the child has a fever or acute illness, vaccination may be postponed until recovery. Consult a doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiration date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of the prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. Do not leave it in a hot car. If traveling across time zones, continue the dosing schedule as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying liquid medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Cough suppression begins within 15-30 minutes, and antihistamine effects within 30-60 minutes. Full effect may take a few doses.
A: No, this medicine should not be given to infants unless specifically prescribed by a pediatrician. Consult a doctor for appropriate dosing.
A: Do not repeat the dose unless advised by a doctor. Wait until the next scheduled dose.
A: Paracetamol can generally be given with this medicine if needed for fever, but consult a doctor to confirm and avoid duplicate ingredients.
🤔 Common Patient Concerns
🔄 Substitutes for cofdrex-d syrup
View AllAlternative brands with exact same active ingredient:
-
fluled plus oral suspensionUniversal Micro Sciences ₹30.00 28.9% CHEAPER
-
mucoresp-3d oral suspensionAzine Healthcare Pvt Ltd ₹30.47 27.8% CHEAPER
-
Netokuf DP SyrupRosnet Pharma ₹32.81 22.2% CHEAPER
-
coldsip syrupNilkanth Lifescience Pvt Ltd ₹37.50 11.1% CHEAPER
-
exil d syrupMedopharm ₹38.44 8.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for dry, non-productive cough. It is not effective for productive cough with mucus and may be harmful in such cases. - Myth: It is safe to give this medicine to children of any age.
Fact: This medicine should not be given to children below the age specified by the prescriber. Always consult a pediatrician. - Myth: More medicine means faster relief.
Fact: Exceeding the dose can cause serious side effects. Always follow the prescribed dose.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine + Dextromethorphan syrup (generic)
Brand Alternatives
- Ambrodil-D Junior Syrup