alertus syrup - Chlorpheniramine Maleate (2mg/5ml) + Phenylephrine (5mg/5ml) medicine

Ascoril Flu Syrup: Complete Medicine Guide

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🏭 Megha Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of allergic rhinitis and common cold.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of the face, lips, or throat
  • Severe headache with blurred vision or confusion
  • Chest pain or palpitations
  • Inability to urinate
  • Seizures or loss of consciousness
  • High fever with rash
  • Yellowing of skin or eyes

If experiencing severe symptoms, call emergency services immediately.

What is alertus syrup used for?

This medicine is a combination of chlorpheniramine maleate (an antihistamine) and phenylephrine (a decongestant) used to relieve symptoms of allergic rhinitis and the common cold, such as nasal congestion, sneezing, and runny nose. It works by blocking histamine and constricting nasal blood vessels. It is available as a syrup for oral use.

  • Generic Name: Chlorpheniramine Maleate + Phenylephrine
  • Manufacturer: Megha Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 alertus syrup के बारे में (Hindi Summary)

उपयोग: यह दवा एलर्जी राइनाइटिस और सामान्य सर्दी-जुकाम के लक्षणों जैसे नाक बंद होना, छींक आना, नाक बहना और आंखों में खुजली से राहत दिलाने के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और फेनिलएफ्रिन होते हैं। यह सिरप के रूप में उपलब्ध है और मुंह से ली जाती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, सिरदर्द और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, रक्तचाप में वृद्धि, पेशाब में रुकावट या दौरे पड़ सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, ग्लूकोमा या पेशाब में कठिनाई है तो डॉक्टर को बताएं। 7 दिनों से अधिक उपयोग न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 alertus syrup Uses & Benefits

[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itching, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief of nasal congestion, sneezing, and runny nose due to upper respiratory tract infections.","evidence":"Well-established"},{"condition":"Upper respiratory tract allergy","description":"Reduces allergic symptoms affecting the nose and throat.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Sinusitis","description":"Sometimes used to relieve congestion associated with sinusitis, but evidence is limited.","evidence":"Limited"},{"condition":"Eustachian tube dysfunction","description":"May be used off-label to reduce congestion, but not routinely recommended.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis and common cold

Also treats: Sinusitis, Upper respiratory tract infections

📋 Drug Information

Generic Name(s)Chlorpheniramine Maleate + Phenylephrine
Brand NameAscoril Flu Syrup
ManufacturerMegha Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Decongestant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Keep the bottle tightly closed. Do not refrigerate unless specified. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Stay well hydrated throughout the day to help thin mucus.
3
Avoid alcohol and other sedatives while taking this medicine.
4
Do not exceed the recommended dose or frequency.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Use a humidifier or saline nasal spray to ease congestion.
7
Avoid driving or operating machinery until you know how this medicine affects you.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Nasal congestion
This medicine is commonly prescribed for this.
Likely Use
Sneezing
This medicine is commonly prescribed for this.
Likely Use
Runny nose
This medicine is commonly prescribed for this.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Chest pain
This medicine is not for chest pain; seek immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine maleate is well absorbed from the gastrointestinal tract after oral administration. Phenylephrine is also absorbed orally but undergoes extensive first-pass metabolism, resulting in reduced systemic bioavailability. Peak plasma concentrations of chlorpheniramine are reached in about 2 to 3 hours. For phenylephrine, peak levels occur within 1 to 2 hours.
DistributionChlorpheniramine maleate is widely distributed throughout the body, including the central nervous system. It crosses the blood-brain barrier and placenta. Phenylephrine distribution is not well characterized but is expected to distribute into tissues, with some penetration into the brain.
Protein BindingChlorpheniramine maleate is approximately 70% bound to plasma proteins. Phenylephrine protein binding is not well established from the available information.
MetabolismChlorpheniramine maleate is metabolized in the liver, primarily by cytochrome P450 enzymes, including CYP2D6, to inactive metabolites. Phenylephrine undergoes extensive first-pass metabolism in the liver and gut wall, mainly by monoamine oxidase and sulfotransferases.
Half-LifeThe elimination half-life of chlorpheniramine maleate is approximately 12 to 43 hours, with a longer half-life in the elderly. The elimination half-life of phenylephrine is approximately 2 to 3 hours.
ExcretionChlorpheniramine maleate and its metabolites are excreted primarily in the urine. Phenylephrine and its metabolites are also excreted mainly in the urine, with some excretion in feces.
BioavailabilityThe oral bioavailability of chlorpheniramine maleate is approximately 25% to 50% due to first-pass metabolism. The oral bioavailability of phenylephrine is low, approximately 38% or less, due to extensive first-pass metabolism.
Onset of ActionThe onset of action for chlorpheniramine maleate is typically within 30 to 60 minutes after oral administration. Phenylephrine's decongestant effect begins within 15 to 30 minutes.
Peak Plasma TimePeak plasma concentrations of chlorpheniramine maleate are reached in about 2 to 3 hours. For phenylephrine, peak plasma levels occur within 1 to 2 hours.
Duration of ActionThe antihistaminic effect of chlorpheniramine maleate lasts approximately 4 to 6 hours, while the decongestant effect of phenylephrine lasts about 4 to 6 hours. The syrup is usually dosed every 4 to 6 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms such as sneezing, rhinorrhea, and itching. Phenylephrine is a sympathomimetic amine that selectively stimulates alpha-1 adrenergic receptors on vascular smooth muscle, causing vasoconstriction in the nasal mucosa, which reduces swelling and congestion. The combination provides relief from both allergic and congestive symptoms.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine maleate binds to histamine H1 receptors on effector cells, preventing histamine from triggering allergic responses such as sneezing, itching, and increased vascular permeability.
2
Alpha-1 adrenergic receptor stimulation: Phenylephrine stimulates alpha-1 adrenergic receptors on nasal blood vessels, causing vasoconstriction and reducing nasal congestion.
3
Anticholinergic effect: Chlorpheniramine maleate also exhibits anticholinergic activity, which reduces secretions and contributes to dry mouth and drowsiness.

💡 How to Take alertus syrup

Strength: Each 5 mL of syrup contains chlorpheniramine maleate 2 mg and phenylephrine 5 mg.

1Shake the bottle well before each use.
2Use the measuring cup or spoon provided with the pack to measure the correct dose.
3Take the medicine orally, with or without food.
4If it causes stomach upset, take it with a meal or snack.
5Do not exceed the recommended dose or frequency.
6After use, close the bottle tightly and store as directed.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 to 10 mL (1 to 2 teaspoons) every 4 to 6 hours, not to exceed 6 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use the measuring cup provided with the pack for accurate dosing.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 2 years of age. For children 2 to 6 years, dose is usually 2.5 mL every 4 to 6 hours; for 6 to 12 years, 5 mL every 4 to 6 hours. However, these are general guidelines and a pediatrician must be consulted.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially drowsiness, confusion, and anticholinergic effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseFor adults: maximum 60 mL (12 teaspoons) in 24 hours. For children: as prescribed by a pediatrician, not to exceed 4 doses in 24 hours.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Caffeine
Limit
May increase nervousness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of alertus syrup

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If drowsiness persists or interferes with daily activities, consult your doctor.
Dry mouth, nose, or throat (Common (5-15%))
Sip water frequently, chew sugarless gum, or use a humidifier. If severe, consult your doctor.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid sudden movements. If persistent, consult your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. If nausea persists, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of the face, lips, or throat, difficulty breathing, or chest tightness.
Hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, blurred vision, chest pain, or shortness of breath.
Urinary retention (Rare (<0.1%))
Consult your doctor if you are unable to urinate or have difficulty urinating.
Seizures (Very rare (<0.01%))
Seek immediate medical attention if you experience convulsions or loss of consciousness.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report any unusual bruising, bleeding, or signs of infection to your doctor immediately.
Hepatotoxicity
Report yellowing of skin or eyes, dark urine, or abdominal pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Tricyclic antidepressants Major
Beta-blockers Major
CNS depressants Moderate
Anticholinergics Moderate
Digitalis Moderate
Antacids Minor
Guanethidine Minor
Alcohol Moderate
Caffeine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants
  • Beta-blockers

⚡ Moderate Interactions

  • Central nervous system depressants (e.g., alcohol, sedatives, tranquilizers)
  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
  • Digitalis glycosides

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair judgment. The combination may also increase the risk of central nervous system depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to chlorpheniramine, phenylephrine, or any component of the formulation","Severe hypertension or severe coronary artery disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs","Children under 2 years of age"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with hypertension, heart disease, diabetes, thyroid disorders, or glaucoma.","Do not use for more than 7 days without consulting a doctor.","Elderly patients are more sensitive to anticholinergic effects and may experience confusion, constipation, or urinary retention.","Phenylephrine may cause increased blood pressure; monitor if you have cardiovascular conditions.","Consult a doctor before use if pregnant or breastfeeding."]

🤱 Lactation Safety

Chlorpheniramine maleate and phenylephrine may pass into breast milk. Consult your doctor before using this medicine while breastfeeding. Caution is advised as it may cause drowsiness in the infant.

💊 Overdose Management

Overdose may cause severe drowsiness, confusion, seizures, hypertension, palpitations, and respiratory depression. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid consuming alcohol or other central nervous system depressants while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you have high blood pressure, heart disease, diabetes, thyroid problems, glaucoma, or difficulty urinating. Do not use this medicine for more than 7 days without consulting a doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the anticholinergic effects of chlorpheniramine, such as confusion, dry mouth, constipation, and urinary retention. They may also be more sensitive to the cardiovascular effects of phenylephrine. Use with caution and monitor closely. Lower doses may be required.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. The safety of this combination during pregnancy has not been established. Alternative treatments may be recommended.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you are taking other medications or have underlying conditions. It may interact with anesthetics and other perioperative drugs.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may interact with local anesthetics or sedatives used during dental work. Your dentist may advise you to stop the medicine temporarily.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated by drinking plenty of fluids.
🥗
Use a humidifier to ease nasal congestion.
😴
Avoid allergens such as dust, pollen, and pet dander.
💧
Get adequate rest to help your body recover.
🧘
Wash your hands frequently to prevent the spread of cold viruses.
🌞
Avoid smoking and exposure to secondhand smoke.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you exercise, do so in a safe environment and stay hydrated.

🥗 Diet Recommendations

Include vitamin C-rich foods like oranges, lemons, and bell peppers.
Consume warm soups and broths to soothe the throat.
Avoid cold beverages and ice cream if you have a sore throat.
Limit caffeine intake as it may increase nervousness.
Eat a balanced diet to support immune function.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. If your work involves operating heavy machinery, inform your employer and consider adjusting your duties temporarily.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any severe side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and anticholinergic side effects. Phenylephrine may cause rebound congestion if used for more than 3 days. Regular monitoring of blood pressure and renal function may be required if used for extended periods. Consult your doctor if you need to use this medicine for more than 7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal irrigation

Helps clear nasal passages and reduce congestion without medication.

Evidence: Well-established
Steam inhalation

Can temporarily relieve nasal congestion.

Evidence: Limited
Antihistamine nasal sprays

Alternative for allergic rhinitis with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place, away from direct sunlight. If crossing time zones, adjust dosing intervals based on your usual schedule, but do not exceed the maximum daily dose. Keep it in your carry-on luggage if flying, as checked baggage may be exposed to extreme temperatures.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergic rhinitis
She started this medicine as prescribed for her sneezing and runny nose. Within 30 minutes, her symptoms improved significantly. She experienced mild drowsiness, so she took it at bedtime. She was advised not to drive after taking it.
💡 Lesson: Taking this medicine at bedtime can help manage drowsiness while providing relief from allergy symptoms.
👤 A 50-year-old man with common cold and nasal congestion
He used this medicine for 5 days and found relief from congestion and sneezing. He was cautioned about his high blood pressure, so he monitored his BP regularly, which remained stable. He stopped the medicine after 5 days as symptoms resolved.
💡 Lesson: Patients with hypertension should monitor blood pressure while taking this medicine and use it for the shortest duration possible.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after oral administration.

Q: How long does the effect last?

A: The effects typically last for about 4 to 6 hours, so it is usually taken every 4 to 6 hours as needed.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

Q: Is it safe for children?

A: It is not recommended for children under 2 years. For older children, consult a pediatrician for appropriate dosing.

Q: Can I take it if I am pregnant?

A: Consult your doctor before using this medicine during pregnancy. The safety has not been established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for alertus syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure a cold.
    Fact: This medicine only provides symptomatic relief; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for weeks.
    Fact: This medicine should not be used for more than 7 days without medical advice due to risk of side effects.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases drowsiness and should be avoided.

🔄 Alternative Options

Generic Alternatives

  • Chlorpheniramine maleate + phenylephrine syrup (various manufacturers)

Brand Alternatives

  • Ascoril Flu Syrup (Glenmark Pharmaceuticals Ltd)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Chlorpheniramine maleate 2mg/5ml + Phenylephrine 5mg/5ml","onset":"30-60 minutes","duration":"4-6 hours","sedation":"High","blood_pressure_effect":"Moderate"},{"medicine":"Cetirizine + phenylephrine syrup","composition":"Cetirizine 5mg/5ml + Phenylephrine 5mg/5ml","onset":"30-60 minutes","duration":"12-24 hours","sedation":"Low","blood_pressure_effect":"Moderate"},{"medicine":"Loratadine + pseudoephedrine syrup","composition":"Loratadine 5mg/5ml + Pseudoephedrine 30mg/5ml","onset":"1-3 hours","duration":"12-24 hours","sedation":"Low","blood_pressure_effect":"High"}]

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