codelite 4 mg/10 mg syrup - Chlorpheniramine Maleate (4mg) + Codeine (10mg) medicine

codelite 4 mg/10 mg syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Tablets India Limited ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is codelite 4 mg/10 mg syrup used for?

Ascoril C Syrup (Chlorpheniramine Maleate + Codeine) is used to treat RESPIRATORY. It contains Chlorpheniramine Maleate (4mg) + Codeine (10mg), which Chlorpheniramine: H1-receptor antagonist; Codeine: mu-opioid receptor agonist. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Chlorpheniramine Maleate + Codeine
  • Manufacturer: Tablets India Limited
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š codelite 4 mg/10 mg syrup Uses & Benefits

Symptomatic relief of cough associated with allergies or cold

Off-label uses: Not commonly used off-label

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Codeine
Brand NameAscoril C Syrup
ManufacturerTablets India Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntitussive and Antihistamine Combination
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract
DistributionWidely distributed; crosses blood-brain barrier and placenta
Protein BindingChlorpheniramine: ~72%; Codeine: ~7-25%
MetabolismChlorpheniramine: Hepatic via CYP450; Codeine: Hepatic via CYP2D6 to morphine
Half-LifeChlorpheniramine: 14-24 hours; Codeine: 2.5-4 hours
ExcretionRenal (primarily as metabolites)
BioavailabilityChlorpheniramine: ~25-50%; Codeine: ~90%
Onset of ActionChlorpheniramine: 30-60 minutes; Codeine: 30-60 minutes
Peak Plasma TimeChlorpheniramine: 2-6 hours; Codeine: 1-2 hours
Duration of ActionChlorpheniramine: 4-6 hours; Codeine: 4-6 hours

How It Works

Chlorpheniramine: H1-receptor antagonist; Codeine: mu-opioid receptor agonist

Mechanism Steps

1Chlorpheniramine blocks H1 receptors, reducing histamine-mediated cough reflex and allergic symptoms
2Codeine binds to mu-opioid receptors in the cough center of the medulla oblongata, suppressing cough reflex
3Codeine is metabolized by CYP2D6 to morphine, which contributes to analgesic and antitussive effects

๐Ÿ’ก How to Take codelite 4 mg/10 mg syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of codelite 4 mg/10 mg syrup

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nausea
  • Constipation

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Hypotension
  • Seizures
  • Serotonin syndrome

โš ๏ธ Rare Side Effects

  • QT prolongation
  • Urinary retention
  • Blurred vision
  • Allergic dermatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Hypertensive crisis, serotonin syndrome
CNS depressants Major Additive sedation and respiratory depression
Alcohol Major Increased sedation and respiratory depression
Opioid analgesics Major Additive opioid effects
Anticholinergics Moderate Increased anticholinergic side effects
Antihypertensives Moderate Enhanced hypotensive effect
CYP2D6 inhibitors Moderate Reduced codeine efficacy or toxicity
Cimetidine Minor Increased chlorpheniramine levels
Ritonavir Minor Increased codeine levels

๐Ÿšจ Major Interactions

  • MAOIs
  • CNS depressants
  • Alcohol
  • Opioid analgesics

โšก Moderate Interactions

  • Anticholinergics
  • Antihypertensives
  • CYP2D6 inhibitors

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Ritonavir

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase codeine levels

๐Ÿท Alcohol Interaction

Enhanced CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, respiratory depression, asthma, MAOI use, children <12 years (codeine risk)

๐Ÿ“Š Monitoring Parameters

Respiratory rate, sedation level, cough frequency, allergic reactions

๐Ÿคฑ Lactation Safety

Not recommended; codeine excreted in breast milk

๐Ÿ’Š Overdose Management

Supportive care, naloxone for codeine overdose, antihistamine toxicity management

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

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