cobagain pg 500mcg/25mg tablet
What is cobagain pg 500mcg/25mg tablet used for?
Axogurd-SR Tablet (Methylcobalamin + Pregabalin) is used to treat NEURO CNS. It contains Methylcobalamin (500mcg) + Pregabalin (25mg), which Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delt. Always consult your doctor before use. Take as prescribed.
- Generic Name: Methylcobalamin + Pregabalin
- Manufacturer: Sentinel Remedies
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cobagain pg 500mcg/25mg tablet Uses & Benefits
Diabetic neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury.
Off-label uses: Generalized anxiety disorder, social anxiety disorder, restless legs syndrome.
๐ Drug Information
| Generic Name(s) | Methylcobalamin + Pregabalin |
| Brand Name | Axogurd-SR Tablet |
| Manufacturer | Sentinel Remedies |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Neurotropic vitamin + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release.
Mechanism Steps
๐ก How to Take cobagain pg 500mcg/25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cobagain pg 500mcg/25mg tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Constipation
๐จ Serious Side Effects
- Angioedema
- Hypersensitivity reactions
- Suicidal thoughts
- Rhabdomyolysis
- PR interval prolongation
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Hepatotoxicity
- Pancreatitis
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CNS depressants | Major | Increased sedation and respiratory depression |
| Thalidomide | Major | Increased risk of peripheral neuropathy |
| ACE inhibitors | Major | Increased risk of angioedema |
| Oral hypoglycemics | Moderate | May enhance hypoglycemic effect |
| Antihypertensives | Moderate | Additive hypotensive effect |
| Antacids | Minor | Reduced absorption of pregabalin |
| H2 blockers | Minor | Possible reduced absorption of pregabalin |
๐จ Major Interactions
- Central nervous system depressants
- Thalidomide
- Angiotensin-converting enzyme inhibitors
โก Moderate Interactions
- Oral hypoglycemics
- Antihypertensives
โน๏ธ Minor Interactions
- Antacids
- H2 blockers
๐ฝ๏ธ Food Interactions
High-fat meal may delay absorption of pregabalin
๐ท Alcohol Interaction
Additive CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; severe renal impairment (CrCl <30 mL/min) for pregabalin.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of hypersensitivity, CNS depression, suicidal ideation.
๐คฑ Lactation Safety
Pregabalin excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; activated charcoal if recent ingestion; hemodialysis may remove pregabalin.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.
Helpful and effective medicine as per my experience. Always consult a doctor.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.