Altovate Cream: A Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, or throat, difficulty breathing.
- Signs of severe skin reaction: blistering, peeling, or sores in mouth or eyes.
- No improvement or worsening of infection after 7 days.
- Development of new fever or chills.
- Increased redness, pain, or pus at the application site.
- Yellowing of skin or eyes (jaundice).
- Decreased urine output or severe abdominal pain.
If experiencing severe symptoms, call emergency services immediately.
What is clotus plus cream used for?
This medicine is a topical antibiotic cream containing ofloxacin and ornidazole. It is used to treat bacterial skin infections, infected wounds, and abscesses. Apply a thin layer to the affected area as directed by your doctor, usually once or twice daily. Do not use in the eyes or mouth. Avoid alcohol during treatment.
- Generic Name: Ofloxacin + Ornidazole
- Manufacturer: Biovensia Pharmaceutical
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clotus plus cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें ऑफ़लोक्सासिन और ओर्निडाज़ोल दो एंटीबायोटिक्स होते हैं। इसका उपयोग त्वचा के बैक्टीरियल संक्रमण, घाव के संक्रमण, फोड़े-फुंसी और सेल्युलाइटिस के इलाज के लिए किया जाता है। यह संक्रमण पैदा करने वाले बैक्टीरिया को मारती है और सूजन, दर्द और मवाद को कम करने में मदद करती है। इसे डॉक्टर के बताए अनुसार प्रभावित हिस्से पर पतली परत में लगाएं। आमतौर पर दिन में एक या दो बार लगानी होती है। इसे आंखों, मुंह या नाक के अंदर न लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, लालिमा या सूखापन शामिल है। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी एलर्जी, चकत्ते या सूजन हो सकती है। गंभीर एलर्जी प्रतिक्रिया दुर्लभ है, लेकिन अगर चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या त्वचा पर छाले पड़ जाएं तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस क्रीम को केवल बाहरी इस्तेमाल के लिए है। लगाने से पहले और बाद में हाथ धोएं। प्रभावित हिस्से को साफ और सूखा करें। डॉक्टर के बताए अनुसार ही लगाएं। आंखों, मुंह और नाक के संपर्क में न आने दें। बिना डॉक्टर की सलाह के लंबे समय तक या बड़े हिस्से पर न लगाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इस दवा का सेवन करते समय शराब न पिएं। बच्चों की पहुंच से दूर रखें।
💊 clotus plus cream Uses & Benefits
[{"condition":"Infected wounds","description":"Used to treat bacterial infection in cuts, abrasions, or surgical wounds.","evidence":"Well-established"},{"condition":"Skin abscesses","description":"Helps resolve pus-filled infections of the skin when used as an adjunct to drainage.","evidence":"Well-established"},{"condition":"Cellulitis","description":"May be used for mild localized cellulitis, often as part of a broader treatment plan.","evidence":"Moderate"},{"condition":"Bacterial skin infections","description":"Effective against a range of gram-positive and gram-negative bacteria and anaerobes.","evidence":"Well-established"},{"condition":"Protozoal skin infections","description":"Ornidazole component targets certain protozoa, though such use is less common.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prevention of infection in minor burns","description":"Sometimes applied to minor burns to prevent bacterial colonization, but not a standard approved use.","evidence":"Limited"},{"condition":"Infected insect bites","description":"May be used off-label for secondary bacterial infection after insect bites.","evidence":"Limited"}]
Primary treatment for: Bacterial skin infections
Also treats: Infected wounds, Skin abscesses, Cellulitis
📋 Drug Information
| Generic Name(s) | Ofloxacin + Ornidazole |
| Brand Name | Altovate Cream |
| Manufacturer | Biovensia Pharmaceutical |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Topical |
| Storage | Store below 30°C in a cool, dry place. Do not freeze. Keep the tube tightly closed when not in use. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with different mechanisms. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to rapid bacterial cell death. Ornidazole is a nitroimidazole that enters susceptible anaerobic bacteria and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA, causing strand breakage and cell death. The combination provides broad-spectrum coverage against aerobic and anaerobic bacteria, as well as certain protozoa.
Mechanism Steps
💡 How to Take clotus plus cream
Strength: Cream containing ofloxacin 0.75% w/w and ornidazole 2% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer to the affected area once or twice daily, or as directed by your doctor. The frequency and duration depend on the type and severity of the infection. Typically, treatment lasts for 5 to 10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended frequency. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients when used topically. However, elderly patients may be more susceptible to skin irritation. Use with caution and monitor for adverse effects. |
| Renal Impairment | No dose adjustment is typically needed for topical use. However, if used over large areas or on broken skin, systemic absorption may occur. Consult a doctor if you have severe kidney disease. |
| Hepatic Impairment | No dose adjustment is typically needed for topical use. However, if used extensively, systemic absorption may occur. Consult a doctor if you have severe liver disease. |
| Maximum Daily Dose | Not established from the available information. Use only as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clotus plus cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Theophylline | Moderate | |
| Other topical antibiotics | Moderate | |
| Alcohol | Major |
🚨 Major Interactions
- Other topical antibiotics
⚡ Moderate Interactions
- Anticoagulants (e.g., warfarin)
- Theophylline
🍷 Alcohol Interaction
Avoid alcohol while using this medicine. Ornidazole can cause a disulfiram-like reaction with alcohol, leading to flushing, nausea, vomiting, and rapid heartbeat, even with topical use due to potential absorption.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to ofloxacin, ornidazole, or any component of the cream","Known allergy to other fluoroquinolones or nitroimidazoles","Application to the eye or mucous membranes","Use in children under 12 years without medical advice"]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes, nose, mouth, and other mucous membranes.","Do not use on large areas or for prolonged periods without medical supervision.","May cause photosensitivity; avoid sun exposure and use sunscreen.","Discontinue if severe irritation or allergic reaction occurs.","Use with caution in patients with liver or kidney disease.","Avoid alcohol during treatment due to disulfiram-like reaction.","Do not use in pregnancy unless clearly needed and advised by a doctor.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known if ofloxacin or ornidazole pass into breast milk after topical use. Consult your doctor before use. Avoid applying to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose from topical application is unlikely. If accidental ingestion occurs, seek immediate medical attention. Symptoms may include nausea, vomiting, and abdominal pain. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
For external use only. Wash your hands before and after applying the cream. Clean and dry the affected area gently before application. Apply a thin layer and rub it in gently as directed. Do not cover the area with airtight dressings unless instructed. Avoid contact with eyes, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water. Do not use on large areas of broken skin or for prolonged periods without medical advice. Do not share this medicine with others. Keep out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Inform your doctor if you have kidney or liver problems. Avoid alcohol consumption while using this medicine as it may cause unpleasant reactions. If symptoms do not improve within a few days or worsen, consult your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have thinner skin and are more prone to irritation. Use with caution and monitor for adverse effects. No specific dose adjustment is needed for topical use.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is generally not recommended during the first trimester. Use effective contraception if advised.
🏥 Post-Surgery Considerations
This cream may be prescribed after surgery to prevent or treat wound infection. Follow your surgeon's instructions for application and wound care. Do not apply to surgical wounds without medical advice.
🦷 Dental Procedures
This medicine is for skin use only and is not used in dental procedures. Inform your dentist if you are using it, as it may indicate an active infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise that may cause friction or sweating over the treated area. Keep the area clean and dry after exercise. If the infection is on the leg or foot, avoid activities that put pressure on the area until healed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or any unusual symptoms, avoid these activities until you feel better. You can continue your normal daily activities, but keep the treated area clean and protected.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if you experience a severe allergic reaction, severe skin irritation, or if your infection worsens or does not improve within 7 days. Do not stop prematurely even if symptoms improve, as this can lead to recurrence and resistance.
📅 Long-Term Use Effects
Long-term use of this cream can lead to bacterial resistance and superinfection with fungi or resistant bacteria. It should only be used for the prescribed duration. If used over large areas for prolonged periods, systemic absorption may occur, and monitoring of liver and kidney function may be advised. Regular review by a doctor is recommended if extended use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cleaning wounds with mild soap and water and keeping them covered can prevent infection.
Evidence: Well-establishedFor minor cuts, antiseptics like povidone-iodine may be sufficient.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have an active infection, consult your doctor about timing of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature, away from direct sunlight and moisture. If traveling to a different time zone, continue your regular application schedule. Declare it at customs if required. Do not leave it in a hot car.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start noticing improvement within 2-3 days. Complete the full course as prescribed, even if symptoms improve.
A: No, it is only for bacterial infections. It will not work for fungal, viral, or allergic skin conditions.
A: Apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Consult your doctor before use. It is generally not recommended in the first trimester.
A: Avoid alcohol during treatment as it may cause a disulfiram-like reaction with ornidazole.
🤔 Common Patient Concerns
🔄 Substitutes for clotus plus cream
View AllAlternative brands with exact same active ingredient:
-
ofloscan-o plus creamMedishri Healthcare ₹60.94 32.3% CHEAPER
-
Trobate Forte CreamEveson Pharma ₹61.88 31.2% CHEAPER
-
fungx creamLancer Therapeutics ₹64.08 28.8% CHEAPER
-
dermiwin oc max creamWindlas Biotech Ltd ₹65.00 27.8% CHEAPER
-
cutiwin-it creamProvectus Life Sciences ₹65.63 27.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin problem.
Fact: It is only for bacterial infections. It will not work for fungal, viral, or allergic skin conditions. - Myth: More cream means faster healing.
Fact: Applying more than prescribed does not speed healing and may increase side effects. - Myth: It is safe to use for long periods without doctor supervision.
Fact: Prolonged use can lead to resistance and superinfection. Use only as prescribed.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin 0.75% w/w + Ornidazole 2% w/w cream (various manufacturers)
Brand Alternatives
- Altovate cream