Clotide 20mg Injection (Eptifibatide): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or uncontrollable bleeding
- Black, tarry stools or blood in vomit
- Sudden severe headache or confusion
- Difficulty breathing or chest pain
- Swelling of face, lips, or throat
- Decreased urine output
- Unusual bruising or petechiae
If experiencing severe symptoms, call emergency services immediately.
What is clotide 20mg injection used for?
Eptifibatide is a glycoprotein IIb/IIIa inhibitor used in hospitals to prevent blood clots in patients with acute coronary syndrome or those undergoing percutaneous coronary intervention. It is given intravenously and requires close monitoring for bleeding.
- Generic Name: Eptifibatide
- Manufacturer: Biocon
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clotide 20mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक्टिव कोरोनरी सिंड्रोम और पर्क्यूटेनियस कोरोनरी इंटरवेंशन (PCI) के दौरान रक्त के थक्के बनने से रोकने के लिए अस्पताल में दी जाती है। यह ग्लाइकोप्रोटीन IIb/IIIa इनहिबिटर वर्ग की दवा है। इसे केवल डॉक्टर की देखरेख में इंट्रावेनस रूप से दिया जाता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर रक्तस्राव, जी मिचलाना, सिरदर्द और निम्न रक्तचाप शामिल हैं। गंभीर दुष्प्रभावों में अत्यधिक रक्तस्राव, थ्रोम्बोसाइटोपेनिया और एलर्जी प्रतिक्रियाएं शामिल हैं। किसी भी असामान्य रक्तस्राव के लक्षण पर तुरंत डॉक्टर को सूचित करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जानी चाहिए। इसे घर पर स्वयं न लें। रक्तस्राव के जोखिम के कारण अन्य दवाओं के साथ सावधानी बरतें। नियमित रूप से प्लेटलेट काउंट और रक्तस्राव के संकेतों की निगरानी करें। गर्भवती महिलाएं डॉक्टर से परामर्श करें।
💊 clotide 20mg injection Uses & Benefits
[{"condition":"Acute Coronary Syndrome (ACS)","description":"Used in patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI) to reduce the risk of thrombotic cardiovascular events.","evidence":"Well-established"},{"condition":"Percutaneous Coronary Intervention (PCI)","description":"Administered during PCI to prevent abrupt closure of the coronary artery and reduce ischemic complications.","evidence":"Well-established"}]
Off-label uses: [{"condition":"ST-elevation myocardial infarction (STEMI) undergoing primary PCI","description":"Sometimes used off-label as an adjunct to primary PCI, though evidence is limited and guidelines vary.","evidence":"Limited"}]
Primary treatment for: Acute Coronary Syndrome
Also treats: Percutaneous Coronary Intervention
📋 Drug Information
| Generic Name(s) | Eptifibatide |
| Brand Name | Clotide |
| Manufacturer | Biocon |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Glycoprotein IIb/IIIa inhibitors |
| Route of Administration | Intravenous |
| Storage | Store at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Eptifibatide is a synthetic cyclic heptapeptide that reversibly binds to the glycoprotein IIb/IIIa receptor on the surface of platelets. By blocking this receptor, it prevents fibrinogen and von Willebrand factor from binding, thereby inhibiting platelet aggregation. This action is dose-dependent and reversible upon discontinuation of the infusion.
Mechanism Steps
💡 How to Take clotide 20mg injection
Strength: 20 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's condition, weight, and renal function. For acute coronary syndrome, a typical regimen includes an intravenous bolus of 180 mcg/kg followed by a continuous infusion of 2 mcg/kg/min. For percutaneous coronary intervention, a second bolus of 180 mcg/kg is given 10 minutes after the first, and the infusion is continued for 18-24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of bleeding. Dose should be individualized by a qualified clinician based on renal function and clinical status. |
| Renal Impairment | In patients with creatinine clearance <50 mL/min, the infusion dose should be reduced to 1 mcg/kg/min. In patients with creatinine clearance <30 mL/min, use is contraindicated. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor closely. |
| Maximum Daily Dose | Not established from the available information. Dosing is individualized by a qualified clinician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clotide 20mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Heparin | Major | |
| Warfarin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Alteplase | Major | |
| Ibuprofen | Moderate | |
| Naproxen | Moderate | |
| SSRIs | Moderate |
🚨 Major Interactions
- Anticoagulants (e.g., heparin, warfarin)
- Thrombolytic agents (e.g., alteplase)
- Other antiplatelet drugs (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen)
- SSRIs
🍷 Alcohol Interaction
Alcohol may increase the risk of bleeding and should be avoided during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active bleeding","History of bleeding disorders","Severe uncontrolled hypertension","Recent stroke (within 30 days)","Major surgery within 6 weeks","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Administer only in a hospital setting with appropriate monitoring.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Monitor for signs of bleeding, especially in patients on anticoagulants.","Thrombocytopenia may occur; monitor platelet count.","Avoid use in patients with active bleeding or high risk of bleeding."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may lead to severe bleeding. There is no specific antidote. Treatment is supportive. Platelet transfusion may be considered. Discontinue the infusion immediately and manage bleeding as clinically indicated.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a hospital setting. Missed doses are not applicable for patients.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a hospital setting. It is not for home use. Patients should inform their doctor about all medications, especially anticoagulants and antiplatelet drugs, as the risk of bleeding increases. Regular monitoring of platelet count, hemoglobin, and signs of bleeding is essential. Avoid activities that may cause injury. Do not take this medicine if you have active bleeding or a history of bleeding disorders. Pregnant women should use it only if clearly needed, as it may cause fetal harm.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding and may have reduced renal function. Dose adjustment and close monitoring are required.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy. This medicine should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used during or after cardiac procedures. Follow your surgeon's instructions regarding activity and wound care.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may increase bleeding risk during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous activities or contact sports that may increase the risk of bleeding or injury while on this medicine. Follow your doctor's advice on activity restrictions.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it does not directly impact daily work. After discharge, you may need to avoid driving or operating machinery if you feel dizzy or weak. Follow your doctor's advice.
🛑 When to Stop This Medicine
This medicine is stopped by the healthcare team based on your clinical condition. Do not stop it on your own. If you experience severe bleeding or allergic reactions, the infusion will be stopped immediately.
📅 Long-Term Use Effects
This medicine is typically used for a short duration (up to 24 hours) in hospital settings. Long-term effects are not established. Prolonged use may increase the risk of bleeding and thrombocytopenia. Regular monitoring is required during therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Tirofiban or abciximab may be used as alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Consult your doctor before receiving any vaccine during treatment.
📦 Storage Guide
✅ DO
Store in refrigerator (2°C to 8°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if expired
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for prolonged periods
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. If you are traveling after treatment, carry a copy of your prescription and medical records. Inform your doctor before travel. No special storage is needed for the patient as it is given in a controlled environment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within minutes after intravenous administration.
A: Common side effects include bleeding, bruising, nausea, and headache.
A: Consult your doctor. It is used only if clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for clotide 20mg injection
View AllAlternative brands with exact same active ingredient:
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eptifab 20mg injectionAbbott ₹1,275.00 49% CHEAPER
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eptibind 20mg injectionTorrent Pharmaceuticals Ltd ₹2,380.95 4.8% CHEAPER
-
eptide 20mg injectionSun Pharmaceutical Industries Ltd ₹2,471.51 1.1% CHEAPER
-
eptiba 20mg injectionIntas Pharmaceuticals Ltd ₹2,500.00 SAME PRICE
-
fleta bolus 20mg injectionLupin Ltd ₹2,500.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Eptifibatide can be taken at home.
Fact: Eptifibatide is given only in a hospital setting under medical supervision. - Myth: Eptifibatide is a blood thinner like warfarin.
Fact: Eptifibatide is an antiplatelet drug, not an anticoagulant. It works by a different mechanism.