Closet 10mg/250mg Tablet: Complete Information Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain that does not improve
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes
- Inability to urinate
- Rapid or irregular heartbeat
- Severe dizziness or confusion
If experiencing severe symptoms, call emergency services immediately.
What is closet 10mg/250mg tablet used for?
This medicine is a combination of dicyclomine (an antispasmodic) and paracetamol (an analgesic) used to relieve abdominal cramps and pain. It works by relaxing gut muscles and reducing pain signals. It is usually taken 2-4 times daily as prescribed.
- Generic Name: Dicyclomine + Paracetamol
- Manufacturer: Totem Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 closet 10mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेट की ऐंठन, दर्द और मरोड़ को कम करने के लिए इस्तेमाल की जाती है। इसमें डाइसाइक्लोमिन और पैरासिटामोल होते हैं। डाइसाइक्लोमिन आंतों की मांसपेशियों को आराम देता है और पैरासिटामोल दर्द कम करता है। यह चिड़चिड़ा आंत्र सिंड्रोम, गैस्ट्रोएंटेराइटिस और पित्त नली की ऐंठन में उपयोगी है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुंह सूखना, धुंधली दृष्टि, चक्कर आना, नींद आना, जी मिचलाना और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, पेशाब रुकना, तेज़ धड़कन या लीवर की समस्या हो सकती है। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। शराब न पिएं क्योंकि इससे लीवर को नुकसान और नींद आ सकती है। अगर आपको ग्लूकोमा, प्रोस्टेट की समस्या, किडनी या लीवर की बीमारी है तो डॉक्टर को बताएं। गाड़ी चलाने से बचें अगर चक्कर या नींद आ रही हो। बच्चों की पहुंच से दूर रखें।
💊 closet 10mg/250mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal cramps and pain associated with IBS by reducing smooth muscle spasms.","evidence":"Well-established"},{"condition":"Gastroenteritis","description":"Helps reduce abdominal cramping and discomfort during infectious or non-infectious gastroenteritis.","evidence":"Commonly used"},{"condition":"Biliary colic","description":"Provides symptomatic relief from pain due to biliary tract spasms.","evidence":"Limited"},{"condition":"Urinary tract spasms","description":"May help relieve spasms in the urinary tract, though evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"Sometimes used to relieve menstrual cramps, but evidence is not robust.","evidence":"Limited"}]
Off-label uses: [{"condition":"Infantile colic","description":"Not recommended due to safety concerns in infants.","evidence":"Not recommended"},{"condition":"Motion sickness","description":"Dicyclomine has anticholinergic properties that may help, but not a standard use.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome
Also treats: Gastroenteritis, Biliary colic, Urinary tract spasms, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Dicyclomine + Paracetamol |
| Brand Name | Abdospas 20mg/500mg Tablet |
| Manufacturer | Totem Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antispasmodic and Analgesic Combination |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. |
| Shelf Life | 24 months from date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Dicyclomine blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing smooth muscle contractions and spasms. Paracetamol acts centrally to inhibit prostaglandin synthesis, thereby reducing pain and fever. Together, they provide antispasmodic and analgesic effects.
Mechanism Steps
💡 How to Take closet 10mg/250mg tablet
Strength: Tablet containing Dicyclomine 10 mg and Paracetamol 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to four times daily, as needed for abdominal cramps and pain. The maximum daily dose should not exceed 4 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to anticholinergic effects. Use with caution and lower doses may be appropriate. Consult a doctor for individualized dosing. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be needed. Consult a doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult a doctor. |
| Maximum Daily Dose | Maximum 4 tablets in 24 hours (providing 40 mg dicyclomine and 1000 mg paracetamol). Do not exceed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of closet 10mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other anticholinergics | Major | |
| Alcohol | Major | |
| Metoclopramide | Moderate | |
| Cholestyramine | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Other anticholinergics (e.g., atropine, antihistamines)
- Warfarin
- Alcohol
⚡ Moderate Interactions
- Metoclopramide
- Cholestyramine
- Tricyclic antidepressants
🍷 Alcohol Interaction
Avoid alcohol consumption while taking this medicine. Alcohol increases the risk of liver toxicity from paracetamol and enhances drowsiness and dizziness from dicyclomine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to dicyclomine, paracetamol, or any component","Glaucoma (narrow-angle)","Myasthenia gravis","Obstructive uropathy (e.g., enlarged prostate)","Severe liver disease","Paralytic ileus","Breastfeeding"]
⚠️ Warnings & Precautions
["Do not exceed recommended dose of paracetamol; risk of severe liver injury.","Avoid alcohol while taking this medicine.","May cause drowsiness or blurred vision; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of anticholinergic effects.","Consult doctor before use in patients with kidney or liver disease.","Do not use for prolonged periods without medical supervision."]
🤱 Lactation Safety
Dicyclomine may pass into breast milk and could cause anticholinergic effects in the infant. Paracetamol is considered safe in breast milk. Consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and anticholinergic toxicity from dicyclomine. Seek emergency medical attention immediately. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Do not consume alcohol while taking this medicine, as it increases the risk of liver damage and drowsiness. Inform your doctor if you have glaucoma, enlarged prostate, kidney or liver disease, or any heart condition. Do not take other paracetamol-containing products simultaneously to avoid overdose. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to anticholinergic effects such as confusion, dry mouth, and urinary retention. Use with caution and lower doses may be needed. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. The safety of this combination in pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, especially if you are on other medications or have underlying conditions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may cause dry mouth, which can affect dental health. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy. Light activities like walking are generally safe. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms improve or if you experience any serious side effects. Do not stop abruptly if you have been taking it regularly for a long time; consult your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of dicyclomine may lead to anticholinergic side effects, and prolonged high-dose paracetamol can increase the risk of liver and kidney damage. Regular monitoring of liver and kidney function may be needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods can help reduce abdominal cramps.
Evidence: Well-establishedYoga, meditation, and counseling can help manage stress-related gut symptoms.
Evidence: ModerateMay help improve gut health and reduce symptoms in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, consult your doctor before any vaccination if you are unwell.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving cramps within 1-2 hours after taking it.
A: It is best taken with food to reduce stomach upset.
A: Consult your doctor before use. The safety profile in pregnancy is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for closet 10mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure irritable bowel syndrome.
Fact: This medicine only provides symptomatic relief; it does not cure the underlying condition. - Myth: It is safe to take this medicine for long periods without doctor supervision.
Fact: Prolonged use can cause side effects and mask serious conditions. Use only as prescribed. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with glaucoma, myasthenia gravis, or certain other conditions.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine + Paracetamol generic tablets
Brand Alternatives
- Not applicable