Clonate-F Cream: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing.
- Signs of systemic steroid effects such as rapid weight gain, rounding of the face, or purple stretch marks on the abdomen.
- Worsening of infection with spreading redness, pus, or fever.
- Severe skin pain, blistering, or peeling.
- Blurred vision or eye pain after accidental contact with eyes.
- Unusual tiredness, weakness, or dizziness that may indicate adrenal suppression.
If experiencing severe symptoms, call emergency services immediately.
What is closalve f cream used for?
This medicine is a topical cream containing clobetasol 0.05% and fusidic acid 2%. It is used to treat infected inflammatory skin conditions such as infected eczema or dermatitis. Apply a thin layer to the affected area once or twice daily for up to 2 weeks, or as prescribed by your doctor.
- Generic Name: Clobetasol + Fusidic Acid
- Manufacturer: Salve Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 closalve f cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें क्लोबेटासोल 0.05% और फ्यूसिडिक एसिड 2% होता है। इसका उपयोग संक्रमित एक्जिमा, संक्रमित डर्मेटाइटिस, संक्रमित सोरायसिस और कीड़े के काटने जैसी त्वचा की सूजन वाली बीमारियों के इलाज के लिए किया जाता है। यह सूजन, लालिमा और खुजली को कम करता है और साथ ही बैक्टीरिया को मारता है। इसे केवल त्वचा पर ही लगाएं, आंखों, होंठों और मुंह के अंदर न लगाएं। इसका उपयोग डॉक्टर के बताए अनुसार ही करें, आमतौर पर 2 सप्ताह से अधिक नहीं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, सूखापन या लालिमा शामिल हैं। ये आमतौर पर अस्थायी होते हैं। लंबे समय तक उपयोग करने पर त्वचा पतली हो सकती है, खिंचाव के निशान पड़ सकते हैं और शरीर में स्टेरॉयड के अवशोषण से अन्य समस्याएं हो सकती हैं। अगर आपको गंभीर एलर्जी, सूजन या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस क्रीम को केवल प्रभावित त्वचा पर ही लगाएं। लगाने से पहले और बाद में हाथ धोएं। आंखों, होंठों और मुंह के अंदर न लगाएं। डॉक्टर की सलाह के बिना चेहरे, बगल या जांघों के बीच न लगाएं। इसे 2 सप्ताह से अधिक समय तक न लगाएं। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 closalve f cream Uses & Benefits
[{"condition":"Infected eczema","description":"Reduces inflammation and itching while treating bacterial infection that complicates eczema flares.","evidence":"Well-established"},{"condition":"Infected dermatitis","description":"Controls contact or atopic dermatitis that has become secondarily infected with bacteria.","evidence":"Well-established"},{"condition":"Infected psoriasis","description":"Helps reduce plaques and treats bacterial infection in psoriatic skin lesions.","evidence":"Moderate"},{"condition":"Infected insect bites","description":"Relieves swelling and itching and prevents or treats infection from scratching.","evidence":"Limited"},{"condition":"Infected minor wounds or cuts","description":"Used short-term to reduce inflammation and bacterial load in superficial infected wounds.","evidence":"Limited"}]
Off-label uses: [{"condition":"Discoid lupus erythematosus","description":"Sometimes used for short courses on resistant skin lesions under specialist supervision.","evidence":"Limited"},{"condition":"Necrobiosis lipoidica","description":"Occasionally prescribed for inflamed lesions, but evidence is weak.","evidence":"Limited"}]
Primary treatment for: Infected inflammatory skin conditions
Also treats: Eczema, Dermatitis, Psoriasis, Insect bites
📋 Drug Information
| Generic Name(s) | Clobetasol + Fusidic Acid |
| Brand Name | Clonate-F Cream |
| Manufacturer | Salve Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Corticosteroid + Antibiotic |
| Route of Administration | Topical |
| Storage | Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep the tube tightly closed when not in use. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines a super-potent topical corticosteroid and a topical antibiotic. Clobetasol binds to glucocorticoid receptors inside skin cells, which leads to reduced production of inflammatory chemicals such as prostaglandins and leukotrienes, and suppression of immune cells that cause redness, swelling, and itching. Fusidic acid works by blocking bacterial protein synthesis. It binds to elongation factor G, preventing the bacteria from making essential proteins, which stops their growth and allows the body's defences and the steroid's anti-inflammatory effect to heal the skin.
Mechanism Steps
💡 How to Take closalve f cream
Strength: Cream containing clobetasol 0.05% w/w and fusidic acid 2% w/w.
Dosage Information
| Adult Dosage | Apply a thin film of this medicine to the affected area once or twice daily, or as directed by your doctor. The usual duration is up to 2 weeks. Do not use more than 50 grams per week. Dose must be individualized by a qualified clinician based on the condition, area of skin, age, and response to treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 1 year of age. |
| Elderly Dosage | Elderly patients may be more susceptible to the side effects of topical corticosteroids, especially skin thinning. Use the lowest effective amount for the shortest possible time. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for topical use in patients with kidney disease. Use with caution and consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is established for topical use in patients with liver disease. Use with caution and consult your doctor. |
| Maximum Daily Dose | Do not apply more than 50 grams of this cream per week. The maximum daily dose should not exceed the amount prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of closalve f cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole (topical or oral) | Major | |
| Ritonavir | Major | |
| Clarithromycin | Major | |
| Prednisolone (oral) | Moderate | |
| Other topical steroids | Moderate | |
| Other topical antibiotics | Moderate | |
| Emollients | Minor |
🚨 Major Interactions
- Other topical corticosteroids
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
⚡ Moderate Interactions
- Other topical antibiotics
- Oral corticosteroids
🍷 Alcohol Interaction
No direct interaction is expected between this topical cream and alcohol. However, alcohol may worsen certain skin conditions and can affect liver function if you are also taking other medicines. It is best to limit alcohol while treating a skin infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to clobetasol, fusidic acid, or any ingredient in the cream","Untreated bacterial, viral, fungal, or parasitic skin infections","Acne vulgaris, rosacea, or perioral dermatitis","Use on the face, groin, or underarms unless specifically prescribed","Children under 1 year of age","Use on large areas or for prolonged periods without medical supervision"]
⚠️ Warnings & Precautions
["For external use only. Do not swallow.","Avoid contact with eyes, lips, and mucous membranes.","Do not use on open wounds or broken skin unless directed by a doctor.","Do not cover with tight bandages or plastic wrap unless instructed.","Use the smallest amount that works for the shortest time possible.","Do not use for more than 2 weeks without medical review.","If you are pregnant or breastfeeding, consult your doctor before use.","Keep out of reach of children.","Do not share this medicine with others."]
🤱 Lactation Safety
It is not known whether clobetasol or fusidic acid pass into breast milk in significant amounts after topical use. To be safe, do not apply this cream to the breasts or nipple area before breastfeeding. If applied to other areas, wash hands before handling the baby. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose from topical application is unlikely. If the cream is accidentally swallowed, seek medical attention immediately. If too much is applied over a large area for a long time, systemic steroid effects may occur. Contact your doctor if you notice unusual weight gain, swelling, or weakness. Treatment is supportive and may include stopping the medicine gradually under medical supervision.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply this medicine only to the affected skin and only as directed by your doctor. Wash your hands before and after applying it, unless your hands are the treated area. Do not cover the treated area with tight bandages, plastic wrap, or diapers unless your doctor tells you to, because this increases absorption and the risk of side effects. Avoid contact with the eyes, lips, and inside the nose or mouth. Do not use this medicine on the face, underarms, or groin unless specifically prescribed, because the skin there is thinner and more prone to steroid damage. Do not use it for longer than the recommended duration, which is usually no more than two weeks. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Keep it out of reach of children. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to skin thinning and systemic side effects from topical corticosteroids. Use the lowest effective amount for the shortest possible time. Monitor for signs of skin atrophy and systemic effects such as high blood sugar and high blood pressure.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Topical corticosteroids should be used during pregnancy only if clearly needed. Avoid prolonged use or application to large areas. Your doctor will weigh the benefits against potential risks.
🏥 Post-Surgery Considerations
If you have recently had surgery, do not apply this cream to surgical wounds unless specifically instructed by your surgeon. It may interfere with wound healing or mask signs of infection. Consult your surgeon before use.
🦷 Dental Procedures
This medicine is for topical skin use and does not directly affect dental procedures. However, if you have a skin infection around the mouth, inform your dentist before any dental work. Avoid applying the cream near the mouth before dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can exercise while using this medicine, but avoid activities that cause excessive sweating or friction on the treated area. Shower after exercise and gently pat the skin dry before reapplying the cream if needed. Avoid swimming in public pools if you have an open infected skin lesion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied to the skin and is unlikely to affect your ability to drive or operate machinery. However, if you experience any dizziness or blurred vision, avoid these activities until you feel normal. You can continue your usual work and daily activities, but avoid sharing towels or clothing with others to prevent spreading infection.
🛑 When to Stop This Medicine
Stop using this medicine after the prescribed duration, usually no more than 2 weeks, or earlier if your doctor advises. If your skin condition worsens or does not improve, consult your doctor before continuing. Do not stop suddenly if you have been using it for a long time without medical advice, as this can cause a flare-up.
📅 Long-Term Use Effects
Long-term use of this medicine can cause skin thinning, stretch marks, visible blood vessels, and increased risk of systemic steroid effects such as high blood sugar, high blood pressure, and adrenal suppression. It can also lead to antibiotic resistance if used unnecessarily. Regular monitoring by a doctor is recommended if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Regular use of emollients can help repair the skin barrier and reduce the need for steroids.
Evidence: Well-establishedFor more extensive skin infections, oral antibiotics may be needed instead of topical antibiotics.
Evidence: Well-establishedFor chronic conditions like psoriasis, phototherapy may be an alternative under specialist care.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction between this topical medicine and vaccines is established. You can receive vaccinations while using this cream. However, if you have a severe skin infection, your doctor may advise delaying vaccination until the infection is controlled.
📦 Storage Guide
✅ DO
Store below 30°C in a dry place
❌ DON'T
Do not freeze or refrigerate
✅ DO
Keep the tube tightly closed
❌ DON'T
Do not leave the cap off
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in a hot car or bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription in case customs officials ask for it. Store it in a cool, dry place away from direct sunlight. Do not leave it in a hot car or checked luggage. If you are crossing time zones, continue applying it at your usual times; topical application does not require strict time zone adjustment. Keep it in your hand luggage if you need it during the flight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may notice improvement in itching and redness within a few days. Full effect usually takes 1 to 2 weeks.
A: No, unless your doctor specifically tells you to. The skin on the face is thin and more prone to steroid side effects.
A: It is not recommended for children under 1 year. For older children, consult a pediatrician for proper dosing and duration.
A: Seek immediate medical attention. Take the tube with you to show the doctor.
🤔 Common Patient Concerns
🔄 Substitutes for closalve f cream
View AllAlternative brands with exact same active ingredient:
-
clobetagen f creamAlkem Laboratories Ltd ₹47.00 66.5% CHEAPER
-
paedisone mf creamPraise Pharma ₹93.75 33.1% CHEAPER
-
dicfu-c creamNidus Pharma Pvt Ltd ₹98.44 29.8% CHEAPER
-
clobiderm-f creamGary Pharmaceuticals Pvt Ltd ₹100.55 28.3% CHEAPER
-
clonova f creamRhine Biogenics Pvt Ltd ₹103.13 26.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin problem.
Fact: It is only for specific infected inflammatory skin conditions and should not be used for acne, rosacea, or fungal infections. - Myth: More cream means faster healing.
Fact: Using more than prescribed increases the risk of side effects without improving results. - Myth: It is safe to use for months.
Fact: Prolonged use can cause skin thinning and systemic side effects. It should generally not be used for more than 2 weeks without medical review.
🔄 Alternative Options
Generic Alternatives
- Clobetasol 0.05% + Fusidic acid 2% cream (generic)
Brand Alternatives
- Clonate-F cream