Clopitab-A 75 Capsule: A Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual weakness or fatigue
If experiencing severe symptoms, call emergency services immediately.
What is clopiril-as tablet used for?
This medicine is a combination of aspirin and clopidogrel used to prevent heart attacks and strokes in people with cardiovascular disease. It works by stopping platelets from sticking together to form clots.
- Generic Name: Aspirin + Clopidogrel
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clopiril-as tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एस्पिरिन और क्लोपिडोग्रेल का संयोजन है, जिसका उपयोग दिल के दौरे और स्ट्रोक को रोकने के लिए किया जाता है। यह रक्त में प्लेटलेट्स को चिपकने से रोकती है और खून के थक्के बनने से बचाती है। इसे आमतौर पर दिल के दौरे के बाद, स्टेंट लगाने के बाद, या पेरिफेरल आर्टरी डिजीज में दिया जाता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में अपच, पेट दर्द, मतली और आसानी से चोट लगने या खून बहने की समस्या शामिल है। गंभीर दुष्प्रभावों में पेट में गंभीर रक्तस्राव, अल्सर और एलर्जी प्रतिक्रिया हो सकती है। अगर काला मल, खून की उल्टी, या त्वचा का पीलापन दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना डॉक्टर की सलाह के इसे अचानक बंद न करें, क्योंकि इससे दिल का दौरा या स्ट्रोक का खतरा बढ़ सकता है। किसी भी सर्जरी या दांत के इलाज से पहले अपने डॉक्टर को इस दवा के बारे में बताएं। शराब का सेवन न करें या सीमित करें। अगर खून बहने या चोट लगने की समस्या हो तो तुरंत डॉक्टर से संपर्क करें।
💊 clopiril-as tablet Uses & Benefits
[{"condition":"Acute coronary syndrome","description":"Used to prevent blood clots in patients with unstable angina or heart attack, often as part of dual antiplatelet therapy.","evidence":"Well-established"},{"condition":"Post-stent placement","description":"Prescribed after coronary stent implantation to prevent stent thrombosis and new cardiovascular events.","evidence":"Well-established"},{"condition":"Peripheral artery disease","description":"Helps reduce the risk of heart attack, stroke, and limb ischemia in patients with narrowed peripheral arteries.","evidence":"Well-established"},{"condition":"Secondary stroke prevention","description":"Used in patients who have had a transient ischemic attack or ischemic stroke to prevent recurrence.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Primary prevention in high-risk individuals","description":"Sometimes considered for patients with multiple risk factors but no prior cardiovascular event, though bleeding risk must be weighed.","evidence":"Limited"}]
Primary treatment for: Cardiovascular disease
Also treats: Acute coronary syndrome, Peripheral artery disease, Ischemic stroke, Transient ischemic attack
📋 Drug Information
| Generic Name(s) | Aspirin + Clopidogrel |
| Brand Name | Aspidol Tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Antiplatelet Agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antiplatelet agents with complementary mechanisms. Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, reducing thromboxane A2 production, which is a potent platelet aggregator and vasoconstrictor. Clopidogrel is a prodrug that is activated in the liver and irreversibly blocks the P2Y12 adenosine diphosphate (ADP) receptor on platelets, preventing ADP-mediated platelet activation and aggregation. Together, they provide stronger and more consistent platelet inhibition than either agent alone.
Mechanism Steps
💡 How to Take clopiril-as tablet
Strength: Capsule containing aspirin 75 mg and clopidogrel 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule (aspirin 75 mg + clopidogrel 75 mg) taken orally once daily, with or without food. For acute coronary syndrome, a loading dose of clopidogrel 300–600 mg may be given separately as directed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be at higher risk of bleeding. Use with caution and monitor closely. Dose adjustment may be needed based on renal and hepatic function. |
| Renal Impairment | No specific dose adjustment is provided in the labeling for mild to moderate renal impairment. Use with caution in severe renal impairment due to increased bleeding risk. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Severe hepatic impairment is a contraindication. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (aspirin 75 mg + clopidogrel 75 mg). Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clopiril-as tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Omeprazole | Major | |
| SSRIs | Major | |
| Heparin | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor | |
| Ginkgo biloba | Minor |
🚨 Major Interactions
- Warfarin
- NSAIDs (e.g., ibuprofen, naproxen)
- SSRIs (e.g., fluoxetine, sertraline)
- Omeprazole
⚡ Moderate Interactions
- Heparin
- Thrombolytics (e.g., alteplase)
- Corticosteroids
🍷 Alcohol Interaction
Alcohol increases the risk of gastrointestinal bleeding and may enhance the blood-thinning effects of this medicine. It is advisable to avoid alcohol or limit intake to no more than one drink per day for men and less for women, after consulting your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active pathological bleeding such as peptic ulcer or intracranial hemorrhage","Known hypersensitivity to aspirin, clopidogrel, or any component of the formulation","Severe liver impairment","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Children and teenagers with viral infections due to risk of Reye's syndrome"]
⚠️ Warnings & Precautions
["Increased risk of bleeding: This medicine can cause serious bleeding. Monitor for signs and symptoms.","Gastrointestinal effects: May cause ulcers and bleeding. Use with caution in patients with a history of GI disease.","Surgery: Discontinue this medicine 5–7 days before elective surgery if possible, after consulting your doctor.","Thrombotic thrombocytopenic purpura (TTP): Rare but serious. Report fever, neurological symptoms, or renal dysfunction.","CYP2C19 poor metabolizers: Clopidogrel may be less effective in patients with reduced CYP2C19 activity.","Aspirin sensitivity: Avoid in patients with aspirin-exacerbated respiratory disease."]
🤱 Lactation Safety
Aspirin and clopidogrel are excreted in human milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may cause severe bleeding, nausea, vomiting, and ringing in the ears. Seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage, activated charcoal, and transfusion of blood products if bleeding occurs. There is no specific antidote for clopidogrel; platelet transfusion may be considered.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it without consulting your doctor, as stopping suddenly can increase your risk of heart attack or stroke. Inform all your healthcare providers, including dentists, that you are taking this medicine before any procedure. Avoid activities that increase the risk of bleeding or injury. Do not take other pain relievers or blood thinners without your doctor's approval. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding and may require closer monitoring. Dose adjustment may be needed based on renal and hepatic function. Falls prevention is important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine may not be safe during pregnancy, especially in the third trimester. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
This medicine increases bleeding risk during and after surgery. It is often stopped 5–7 days before elective surgery. Do not restart without your surgeon's advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental work. You may need to stop it temporarily before invasive procedures, but only under your doctor's guidance.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities that increase the risk of injury and bleeding. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may increase bleeding risk, so avoid activities that could cause injury. It generally does not affect driving or operating machinery, but if you experience dizziness or vision changes, avoid these activities and consult your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is usually continued long-term. Your doctor may decide to stop it after a certain period, depending on your condition and risk of bleeding.
📅 Long-Term Use Effects
Long-term use of this medicine increases the risk of bleeding, including gastrointestinal and intracranial hemorrhage. Regular monitoring of hemoglobin, platelet count, and signs of bleeding is recommended. It is important to continue taking it as prescribed to prevent cardiovascular events. Your doctor may adjust the duration based on your condition.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used if clopidogrel is not tolerated or not needed.
Evidence: Well-establishedUsed when aspirin is contraindicated or not tolerated.
Evidence: Well-establishedA more potent antiplatelet agent used in acute coronary syndrome.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for surgery or dental procedures, inform your doctor. Vaccinations can be given as usual.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If traveling across time zones, continue taking your dose at the same local time as much as possible. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Aspirin starts working within 1 hour, while clopidogrel takes about 2 hours after a loading dose. Full antiplatelet effect with daily dosing is achieved in 3–7 days.
A: No, you should not stop without consulting your doctor. Stopping suddenly can increase the risk of heart attack or stroke.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for clopiril-as tablet
View AllAlternative brands with exact same active ingredient:
-
starclop-a 75mg/75mg capsuleZinnia Life Sciences ₹2.91 83.8% CHEAPER
-
myogrel ap 75mg/75mg tabletMacleods Pharmaceuticals Pvt Ltd ₹18.09 0.5% COSTLIER
-
davaindia aspirin+clopidogrel 75mg/75mg tabletDavaindia Generic Pharmacy ₹20.00 11.1% COSTLIER
-
carpigrel-a tabletShrrishti Health Care Products Pvt Ltd ₹22.27 23.7% COSTLIER
-
clopid as 75mg/75mg tabletHetero Drugs Ltd ₹23.12 28.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once you feel better.
Fact: No, this medicine is usually a long-term treatment. Stopping suddenly can increase the risk of heart attack or stroke. - Myth: This medicine is a painkiller.
Fact: This medicine is an antiplatelet agent, not a painkiller. It is used to prevent blood clots. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of stomach bleeding and should be avoided or limited.
🔄 Alternative Options
Generic Alternatives
- Aspirin + Clopidogrel combination capsules from other manufacturers
Brand Alternatives
- Clopilet A 75
- Deplatt A 75
- Ecosprin AV 75
- Loprin 75
- Noklot 75