clomipreg m 100mg/3mg tablet - Uses, Price, Side Effects & Substitutes
What is clomipreg m 100mg/3mg tablet used for?
Clomipure 100 Capsule (Clomiphene + Melatonin) is used to treat GYNAECOLOGICAL. It contains Clomiphene (100mg) + Melatonin (3mg), which Clomiphene: Blocks estrogen receptors in hypothalamus, increasing GnRH release a. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clomiphene + Melatonin
- Manufacturer: Unimarck Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ clomipreg m 100mg/3mg tablet Uses & Benefits
Ovulation induction in anovulatory infertility, Polycystic ovary syndrome (PCOS), Sleep disorders (melatonin component)
Off-label uses: Male infertility (clomiphene), Jet lag (melatonin)
๐ Drug Information
| Generic Name(s) | Clomiphene + Melatonin |
| Brand Name | Clomipure 100 Capsule |
| Manufacturer | Unimarck Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Selective Estrogen Receptor Modulator (SERM) + Hormone |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Clomiphene: Blocks estrogen receptors in hypothalamus, increasing GnRH release and stimulating ovulation. Melatonin: Regulates circadian rhythm and acts as antioxidant.
Mechanism Steps
๐ก How to Take clomipreg m 100mg/3mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clomipreg m 100mg/3mg tablet
โ Common Side Effects
- Hot flashes
- Abdominal discomfort
- Nausea
- Headache
- Dizziness
- Drowsiness (melatonin)
๐จ Serious Side Effects
- Ovarian hyperstimulation syndrome (OHSS)
- Visual disturbances
- Thromboembolism
- Liver injury
โ ๏ธ Rare Side Effects
- Ovarian cancer (long-term)
- Seizures
- Allergic reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Tamoxifen | Major | Additive risk of thromboembolism |
| CYP2D6 inhibitors | Major | Increased clomiphene toxicity |
| Fluvoxamine | Moderate | Increased melatonin levels |
| Oral contraceptives | Moderate | Reduced clomiphene efficacy |
๐จ Major Interactions
- Tamoxifen
- Aromatase inhibitors
- CYP2D6 inhibitors (e.g., paroxetine)
โก Moderate Interactions
- CYP1A2 inhibitors (e.g., ciprofloxacin)
- Fluvoxamine
- Oral contraceptives
โน๏ธ Minor Interactions
- Caffeine
- Theophylline
- Vitamin supplements
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase clomiphene levels, High-fat meals may delay absorption
๐ท Alcohol Interaction
Avoid alcohol; may increase side effects like dizziness and liver strain.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Pregnancy, Liver disease, Ovarian cysts, Endometrial cancer, Hypersensitivity
๐ Monitoring Parameters
Ovulation (ultrasound, LH surge), Liver function tests, Estradiol levels
๐คฑ Lactation Safety
Not recommended; may suppress lactation.
๐ Overdose Management
Symptomatic and supportive; monitor for ovarian hyperstimulation syndrome (OHSS).
โฐ Missed Dose
Take as soon as remembered; skip if near next dose. Do not double dose.