Aflox TZ 200mg/600mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe joint pain, swelling, or inability to move a joint
- Numbness, tingling, or burning in hands or feet
- Seizures or convulsions
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing
- Bloody diarrhea or severe abdominal pain
- Yellowing of skin or eyes (jaundice)
- Irregular heartbeat or palpitations
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is clof tz 200 mg/600 mg tablet used for?
This medicine is a combination of Ofloxacin (200 mg) and Tinidazole (600 mg) used to treat mixed bacterial and protozoal infections. It works by killing bacteria and protozoa. It is taken orally, usually once or twice daily, and alcohol must be avoided during treatment.
- Generic Name: Ofloxacin + Tinidazole
- Manufacturer: Clyde Biotech P Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clof tz 200 mg/600 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ऑफ़्लोक्सासिन और टिनिडाज़ोल का संयोजन है, जिसका उपयोग विभिन्न जीवाणु और प्रोटोज़ोआ संक्रमणों के इलाज के लिए किया जाता है। यह पेट और आंतों के संक्रमण, अमीबिक लीवर एब्सेस, गियार्डिया, ट्राइकोमोनिएसिस और कुछ प्रकार के दस्त के इलाज में प्रभावी है। यह दवा कीटाणुओं को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें और शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, टेंडन टूटना, दौरे और त्वचा पर गंभीर प्रतिक्रियाएँ शामिल हो सकती हैं। शराब के साथ इस दवा का सेवन करने पर गंभीर प्रतिक्रिया हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। उपचार का पूरा कोर्स करें, बीच में न छोड़ें। शराब का सेवन बिल्कुल न करें और दवा बंद करने के 72 घंटे बाद तक भी न करें। दवा लेते समय चक्कर आ सकते हैं, इसलिए वाहन न चलाएँ। धूप से बचें और सनस्क्रीन का उपयोग करें। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ इस दवा को 2 घंटे के अंतराल पर लें। गर्भवती या स्तनपान कराने वाली महिलाएँ डॉक्टर से सलाह लें।
💊 clof tz 200 mg/600 mg tablet Uses & Benefits
[{"condition":"Amoebic liver abscess","description":"Used to treat liver abscess caused by Entamoeba histolytica, often as part of a combination regimen.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Effective against Giardia lamblia infection causing diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Trichomoniasis","description":"Treats Trichomonas vaginalis infection in women and men.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Used in some regimens to treat mixed anaerobic and aerobic vaginal infections.","evidence":"Moderate"},{"condition":"Pelvic inflammatory disease","description":"Part of combination therapy for PID when both aerobic and anaerobic coverage is needed.","evidence":"Moderate"},{"condition":"Infectious diarrhea","description":"Used when bacterial or protozoal causes are suspected, especially in persistent cases.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Dental infections","description":"Sometimes used off-label for mixed aerobic-anaerobic dental abscesses, but not first-line.","evidence":"Limited"},{"condition":"Skin and soft tissue infections","description":"Occasionally used off-label for mixed infections, but other agents are preferred.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal infections
Also treats: Amoebic liver abscess, Giardiasis, Trichomoniasis, Bacterial vaginosis, Pelvic inflammatory disease
📋 Drug Information
| Generic Name(s) | Ofloxacin + Tinidazole |
| Brand Name | Aflox TZ 200mg/600mg Tablet |
| Manufacturer | Clyde Biotech P Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines may recommend specific antimicrobials for each indication; this combination is used in some settings but not universally recommended by WHO for all indications. |
| ICMR Guideline | Not established from the available information. ICMR guidelines may recommend this combination for specific infections based on local resistance patterns. Consult current guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with different mechanisms. Ofloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to double-strand DNA breaks and bacterial cell death. Tinidazole is a nitroimidazole prodrug that enters anaerobic organisms and protozoa, where its nitro group is reduced to reactive intermediates. These intermediates bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, leading to cell death. The combination provides broad coverage against aerobic bacteria (ofloxacin) and anaerobic bacteria and protozoa (tinidazole).
Mechanism Steps
💡 How to Take clof tz 200 mg/600 mg tablet
Strength: Each tablet contains Ofloxacin 200 mg and Tinidazole 600 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, depending on the infection being treated. For example, in amoebic liver abscess, it may be taken once daily for 5-10 days. For giardiasis, a single dose or a 3-day course may be used. For trichomoniasis, a single dose or a 5-day course is common. The exact dose and duration must be individualized by a qualified clinician based on the indication, severity of infection, age, weight, renal and hepatic function, and clinical response. Do not self-medicate. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of tendon rupture and CNS effects. Dose adjustment may be necessary based on renal function. Use with caution. |
| Renal Impairment | Ofloxacin requires dose adjustment in patients with renal impairment. For creatinine clearance less than 50 mL/min, the dose may need to be reduced or the interval increased. Tinidazole does not require renal dose adjustment. Consult your doctor for specific guidance. |
| Hepatic Impairment | Tinidazole is metabolized in the liver. In patients with severe hepatic impairment, dose reduction may be considered. Ofloxacin undergoes limited hepatic metabolism. Monitor liver function. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose of this combination is generally one tablet twice daily (Ofloxacin 400 mg + Tinidazole 1200 mg per day). However, the exact maximum dose must be determined by a qualified clinician based on the indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clof tz 200 mg/600 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Antacids | Major | |
| Amiodarone | Major | |
| Caffeine | Moderate | |
| Theophylline | Moderate | |
| NSAIDs | Moderate | |
| Cimetidine | Minor | |
| Probenecid | Minor | |
| Iron supplements | Moderate |
🚨 Major Interactions
- Warfarin
- Alcohol
- Antacids, sucralfate, iron, zinc
- QT-prolonging drugs (e.g., amiodarone, sotalol)
⚡ Moderate Interactions
- Caffeine
- Theophylline
- NSAIDs
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 72 hours after the last dose. Tinidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ofloxacin, tinidazole, other quinolones, or nitroimidazoles","History of tendon disorders with fluoroquinolone use","Myasthenia gravis","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding unless clearly needed","Severe renal impairment (dose adjustment needed)","Epilepsy or seizure disorders (use with caution)","Alcohol consumption during and for 72 hours after treatment"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and CNS effects. Reserve for patients with no alternative treatment options.","Avoid alcohol during and for 72 hours after treatment due to disulfiram-like reaction.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","May increase sensitivity to sunlight; avoid excessive sun exposure and use sunscreen.","Take at least 2 hours apart from antacids, sucralfate, iron, or zinc supplements.","Use with caution in elderly patients due to increased risk of tendon rupture and renal impairment.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Inform your doctor if you have kidney or liver disease, epilepsy, or heart conditions."]
🤱 Lactation Safety
Ofloxacin and tinidazole are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. There is no specific antidote. Treatment is symptomatic and supportive. Maintain adequate hydration. In case of overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you feel better, as this can lead to resistance. Take the tablet with a full glass of water, with or without food, but taking it with food may reduce stomach upset. Avoid alcohol completely during treatment and for at least 72 hours after the last dose, because tinidazole can cause a severe reaction with alcohol. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Avoid excessive sunlight and use sunscreen, as ofloxacin can make your skin more sensitive to sunlight. Inform your doctor if you have kidney or liver disease, epilepsy, myasthenia gravis, or tendon problems. Do not take antacids, sucralfate, or iron/zinc supplements within 2 hours before or after this medicine, as they can reduce its absorption. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, renal impairment, and CNS effects. Dose adjustment may be needed based on renal function. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Both ofloxacin and tinidazole should be used during pregnancy only if clearly needed. Discuss alternative options with your doctor.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if there is a risk of mixed bacterial and anaerobic infection. Consult your surgeon. Avoid alcohol during recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. Avoid alcohol-based mouthwashes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. If you experience joint pain, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause nausea or stomach upset, which can affect your work. Take it with food to minimize these effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to resistance and relapse. If you experience serious side effects like tendon pain, numbness, seizures, or severe allergic reactions, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bacterial resistance, fungal overgrowth, and rare but serious effects like peripheral neuropathy or tendon damage. It is not intended for prolonged use unless specifically directed by a doctor. Regular monitoring of kidney and liver function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help restore gut flora during and after antibiotic treatment.
Evidence: ModerateEssential for managing diarrhea and preventing dehydration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually, but do not double dose. Check customs regulations for carrying prescription medicines. Avoid alcohol during travel. Stay hydrated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but you must complete the full prescribed course.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: Avoid alcohol completely, and avoid taking antacids, iron, or zinc supplements within 2 hours of this medicine.
A: Consult your doctor. It is used during pregnancy only if clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for clof tz 200 mg/600 mg tablet
View AllAlternative brands with exact same active ingredient:
-
oflochem tz syrupBiochem Pharmaceutical Industries ₹11.83 84.5% CHEAPER
-
oflotas tz syrupIntas Pharmaceuticals Ltd ₹12.89 83.1% CHEAPER
-
ofrex tz 200mg/600mg suspensionZydus Cadila ₹20.32 73.4% CHEAPER
-
oxo tz 200mg/600mg tabletInd Swift Laboratories Ltd ₹22.90 70% CHEAPER
-
eufox tz 200mg/600mg tabletLupin Ltd ₹23.44 69.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any diarrhea.
Fact: It is only effective for specific bacterial and protozoal infections. It does not work for viral diarrhea or other causes. - Myth: You can stop taking it once you feel better.
Fact: You must complete the full prescribed course to prevent resistance and relapse. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction with tinidazole. Avoid completely.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin 200 mg + Tinidazole 600 mg tablet (various manufacturers)