Clarinerve Tablet
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
What is clarinerve tablet used for?
This medicine contains Gabapentin (200mg) + Nortriptyline (5mg) and is used to treat NEURO CNS. Gabapentin: Binds to α2δ subunit of voltage-gated calcium channels, reducing calcium influx and ne. Always consult your doctor before use.
- Generic Name: Gabapentin + Nortriptyline
- Manufacturer: Clarisse Pharmaceuticus
- Form: Allopathy
- Pregnancy Category: Category A
- Prescription Required: Yes
💊 clarinerve tablet Uses & Benefits
Neuropathic pain, fibromyalgia, diabetic neuropathy, postherpetic neuralgia, depression with neuropathic pain.
Off-label uses: Migraine prophylaxis, restless legs syndrome, bipolar disorder, anxiety disorders.
📋 Drug Information
| Generic Name(s) | Gabapentin + Nortriptyline |
| Brand Name | Acegaba NT 400mg/10mg Tablet |
| Manufacturer | Clarisse Pharmaceuticus |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25°C (68-77°F), protect from light and moisture. |
| Shelf Life | As per manufacturer |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Gabapentin: Binds to α2δ subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline: Inhibits reuptake of norepinephrine and serotonin, potentiating their effects.
Mechanism Steps
💡 How to Take clarinerve tablet
Follow your doctor's prescription exactly.
⚠️ Side Effects of clarinerve tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CNS depressants | Major | Enhanced sedation and respiratory depression |
| Alcohol | Major | Increased CNS depression |
| Anticholinergics | Major | Additive anticholinergic effects |
| CYP2D6 inhibitors | Moderate | Increased nortriptyline levels |
| CYP3A4 inducers | Moderate | Decreased nortriptyline levels |
| Antihypertensives | Moderate | Additive hypotensive effect |
| QTc-prolonging drugs | Moderate | Increased risk of arrhythmias |
| Antacids | Minor | Reduced gabapentin absorption |
| Cimetidine | Minor | Increased nortriptyline levels |
| Oral contraceptives | Minor | Possible reduced contraceptive efficacy |
🚨 Major Interactions
- MAOIs
- CNS depressants
- Alcohol
- Anticholinergics
⚡ Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inducers
- Antihypertensives
- QTc-prolonging drugs
🍷 Alcohol Interaction
Increased CNS depression and sedation; avoid concurrent use.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe renal impairment (CrCl
🤱 Lactation Safety
Not recommended; both drugs excreted in breast milk.
💊 Overdose Management
Supportive care; activated charcoal, gastric lavage; for nortriptyline, monitor ECG and treat arrhythmias; gabapentin overdose may require hemodialysis.
⏰ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
🔄 Substitutes for clarinerve tablet
View AllAlternative brands with exact same active ingredient:
-
bagnor tabletAAR ESS Remedies Pvt Ltd ₹139.69 26.5% CHEAPER
-
vesopro nt 200mg/5mg tabletGlobus Remedies Ltd ₹159.38 16.1% CHEAPER
-
myolin nt 200mg/5mg tabletSolarium Pharmaceuticals ₹182.80 3.8% CHEAPER
-
vscover-nt tabletZunison Healthcare ₹220.10 15.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.