Abetin-NT 200 Tablet - Uses, Price, Side Effects
What is abetin-nt 200 tablet used for?
Abetin-NT 200 Tablet is a combination of Gabapentin (200mg) and Nortriptyline (10mg) used to treat neuropathic pain. Gabapentin calms overactive nerves, while Nortriptyline enhances pain relief by affecting brain chemicals. It is also used for epilepsy and depression-related pain. Take as prescribed, usually twice daily.
- Generic Name: Gabapentin + Nortriptyline
- Manufacturer: Numedix Life Sciences
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ abetin-nt 200 tablet Uses & Benefits
Neuropathic pain, fibromyalgia, diabetic neuropathy, postherpetic neuralgia, depression with neuropathic pain.
Off-label uses: Migraine prophylaxis, restless legs syndrome, bipolar disorder, anxiety disorders.
๐ Drug Information
| Generic Name(s) | Gabapentin + Nortriptyline |
| Brand Name | Acegaba NT 400mg/10mg Tablet |
| Manufacturer | Numedix Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gabapentin: Binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline: Inhibits reuptake of norepinephrine and serotonin, potentiating their effects.
Mechanism Steps
๐ก How to Take abetin-nt 200 tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of abetin-nt 200 tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
- Peripheral edema
๐จ Serious Side Effects
- Suicidal thoughts
- Seizures
- QTc prolongation
- Arrhythmias
- Serotonin syndrome
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Agranulocytosis
- Pancreatitis
- Rhabdomyolysis
- Angle-closure glaucoma
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | Increased CNS depression and dizziness |
| MAOIs | Major | Risk of serotonin syndrome |
| Antihistamines | Moderate | Enhanced sedative effects |
๐จ Major Interactions
- MAOIs
- CNS depressants
- Alcohol
- Anticholinergics
โก Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inducers
- Antihypertensives
- QTc-prolonging drugs
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Oral contraceptives
๐ฝ๏ธ Food Interactions
High-fat meals may reduce gabapentin absorption; avoid grapefruit juice with nortriptyline.
๐ท Alcohol Interaction
Increased CNS depression and sedation; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe renal impairment (CrCl <30 mL/min), narrow-angle glaucoma, urinary retention.
๐ Monitoring Parameters
Renal function, liver function, ECG (QTc), serum drug levels (nortriptyline), blood pressure, mental status.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care; activated charcoal, gastric lavage; for nortriptyline, monitor ECG and treat arrhythmias; gabapentin overdose may require hemodialysis.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.