cladrim 10mg injection - Cladribine (10mg) medicine

cladrim 10mg injection

4.5 (11 reviews)
๐Ÿญ Fresenius Kabi India Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is cladrim 10mg injection used for?

Cladrim 10mg Injection (Cladribine) is used to treat ANTI NEOPLASTICS. It contains Cladribine (10mg), which Cladribine is a purine analog that inhibits DNA synthesis and repair, leading to. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Cladribine
  • Manufacturer: Fresenius Kabi India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š cladrim 10mg injection Uses & Benefits

Hairy cell leukemia; multiple sclerosis (oral form); chronic lymphocytic leukemia.

Off-label uses: Systemic lupus erythematosus; autoimmune hemolytic anemia.

๐Ÿ“‹ Drug Information

Generic Name(s)Cladribine
Brand NameCladrim 10mg Injection
ManufacturerFresenius Kabi India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAntimetabolites
Route of AdministrationIntravenous infusion.
StorageStore at 2-8ยฐC; protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability.
DistributionWidely distributed in body tissues; crosses blood-brain barrier.
Protein BindingApproximately 20% bound to plasma proteins.
MetabolismPrimarily intracellular phosphorylation to active triphosphate; also metabolized by deamination via adenosine deaminase.
Half-LifeApproximately 5.4 hours (biphasic: alpha half-life 25 min, beta half-life 6.7 hours).
ExcretionRenal excretion; about 50% of dose recovered in urine as unchanged drug and metabolites.
Bioavailability100% (intravenous administration).
Onset of ActionRapid; within hours to days.
Peak Plasma TimeImmediately after IV infusion.
Duration of ActionVariable; effects on lymphocytes persist for weeks to months.

How It Works

Cladribine is a purine analog that inhibits DNA synthesis and repair, leading to lymphocyte depletion.

Mechanism Steps

1Cladribine enters cells via nucleoside transporters.
2Phosphorylated by deoxycytidine kinase to cladribine monophosphate.
3Further phosphorylated to active triphosphate (CdATP).

๐Ÿ’ก How to Take cladrim 10mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cladrim 10mg injection

โœ… Common Side Effects

  • Myelosuppression
  • Nausea
  • Headache
  • Fatigue
  • Fever

๐Ÿšจ Serious Side Effects

  • Severe infections
  • Prolonged myelosuppression
  • Neurotoxicity
  • Renal toxicity

โš ๏ธ Rare Side Effects

  • Pulmonary fibrosis
  • Cardiotoxicity
  • Secondary malignancies

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Live vaccines Moderate Risk of disseminated infection
Allopurinol Minor Possible increased cladribine toxicity

๐Ÿšจ Major Interactions

  • Warfarin
  • Other anticoagulants
  • Myelosuppressive agents
  • Nephrotoxic drugs

โšก Moderate Interactions

  • Live vaccines
  • Immunosuppressants
  • Corticosteroids

โ„น๏ธ Minor Interactions

  • Allopurinol
  • Acetaminophen

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

Avoid alcohol due to potential hepatotoxicity.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to cladribine; severe infections; pregnancy; lactation; severe bone marrow suppression.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC), liver function tests, renal function, signs of infection.

๐Ÿคฑ Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

๐Ÿ’Š Overdose Management

Supportive care; monitor for myelosuppression and infections.

โฐ Missed Dose

Administer as soon as remembered; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

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