Ciprolac TZ 500mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or bloody diarrhoea
- Sudden tendon pain or swelling
- Tingling or numbness in hands or feet
- Seizures or confusion
- Swelling of face, lips, or throat
- Difficulty breathing
- Yellowing of eyes or skin
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is ciprolac tz 500mg/250mg tablet used for?
This medicine is a combination antibiotic and antiprotozoal tablet containing ciprofloxacin 500 mg and tinidazole 250 mg. It is used to treat mixed infections of the gut, pelvis, and dental areas. It works by killing bacteria and parasites. It must be taken exactly as prescribed, with food, and alcohol must be avoided.
- Generic Name: Ciprofloxacin + Tinidazole
- Manufacturer: Sivling Technologies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ciprolac tz 500mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिप्रोफ्लोक्सासिन और टिनिडाजोल का संयोजन है, जिसका उपयोग आंतों, पेल्विक और दांतों के मिश्रित संक्रमणों के इलाज के लिए किया जाता है। यह दस्त, अमीबिक पेचिश, जियार्डिया और कुछ पेल्विक संक्रमणों में प्रभावी है। यह दवा बैक्टीरिया और परजीवियों को मारती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुंह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में गंभीर दस्त, टेंडन टूटना, तंत्रिका समस्याएं, दौरे और एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको गंभीर या खूनी दस्त, सूजन, सांस लेने में कठिनाई, या पीलिया हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के निर्देश पर ही लें और पूरा कोर्स करें। इसे भोजन के साथ लें ताकि पेट खराब न हो। उपचार के दौरान और आखिरी खुराक के 72 घंटे बाद तक शराब न लें। एंटासिड, दूध, आयरन या जिंक सप्लीमेंट इस दवा से 2 घंटे पहले या बाद में न लें। चक्कर आने पर वाहन न चलाएं। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं।
💊 ciprolac tz 500mg/250mg tablet Uses & Benefits
[{"condition":"Infectious diarrhoea with mixed aerobic and anaerobic bacteria","description":"This medicine is used to treat diarrhoea caused by susceptible bacteria when both aerobic and anaerobic organisms are suspected.","evidence":"Well-established"},{"condition":"Amoebic dysentery","description":"Tinidazole kills Entamoeba histolytica, while ciprofloxacin covers secondary bacterial infection in the gut.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Tinidazole is effective against Giardia lamblia, and ciprofloxacin may help with associated bacterial overgrowth.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Used as part of combination therapy for polymicrobial pelvic infections when anaerobic coverage is needed.","evidence":"Moderate"},{"condition":"Dental infections with anaerobic bacteria","description":"Prescribed for severe dental abscesses or gum infections where anaerobes are likely.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Refractory pouchitis","description":"Sometimes used off-label for chronic pouch inflammation after ileal pouch-anal anastomosis.","evidence":"Limited"},{"condition":"Prevention of infection after colorectal surgery","description":"Occasionally used off-label as part of surgical prophylaxis in some settings.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal infections of the gastrointestinal tract
Also treats: Amoebic dysentery, Giardiasis, Pelvic inflammatory disease, Dental infections
📋 Drug Information
| Generic Name(s) | Ciprofloxacin + Tinidazole |
| Brand Name | Alcipro TN 500 mg/600 mg Tablet |
| Manufacturer | Sivling Technologies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobials with different mechanisms. Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes needed for DNA replication, repair, and transcription. This leads to double-strand DNA breaks and bacterial cell death. Tinidazole is a prodrug that enters anaerobic organisms and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA and inhibit nucleic acid synthesis. The combination provides broad coverage against many aerobic gram-negative bacteria and anaerobic bacteria or protozoa.
Mechanism Steps
💡 How to Take ciprolac tz 500mg/250mg tablet
Strength: Ciprofloxacin 500 mg and Tinidazole 250 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, or as prescribed by your doctor. The exact dose and duration depend on the type and severity of infection, your kidney and liver function, and other medical conditions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on kidney function. They are at higher risk of tendon rupture, central nervous system effects, and heart rhythm problems. Close monitoring is advised. |
| Renal Impairment | Dose adjustment is required in patients with reduced kidney function. For creatinine clearance below 30 mL/min, the dose may need to be reduced or the interval extended. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Tinidazole is metabolized in the liver. In severe liver impairment, dose reduction may be necessary. Monitor liver function tests. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed what is prescribed by your doctor. Typically, the maximum adult dose is one tablet twice daily, but this may vary based on indication and renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ciprolac tz 500mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Tizanidine | Major | |
| Theophylline | Major | |
| Amiodarone | Major | |
| Antacids | Moderate | |
| NSAIDs | Moderate | |
| Sulfonylureas | Moderate | |
| Methotrexate | Moderate | |
| Phenytoin | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Warfarin
- Tizanidine
- Theophylline
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Alcohol
⚡ Moderate Interactions
- Antacids, sucralfate, iron, zinc, calcium
- NSAIDs (e.g., ibuprofen, naproxen)
- Oral antidiabetic drugs (sulfonylureas)
- Methotrexate
- Phenytoin
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 72 hours after the last dose. Tinidazole can cause a disulfiram-like reaction with alcohol, leading to severe nausea, vomiting, flushing, headache, and palpitations. Alcohol may also worsen liver-related side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to ciprofloxacin, tinidazole, or other quinolone or nitroimidazole drugs","Pregnancy and breastfeeding","Children and adolescents under 18 years (unless specifically prescribed by a specialist)","History of tendon disorders related to fluoroquinolone use","Myasthenia gravis","Severe liver impairment","Known QT interval prolongation or uncorrected hypokalemia","Alcohol use during treatment and for 72 hours after"]
⚠️ Warnings & Precautions
["Fluoroquinolones can cause tendon inflammation and rupture, especially in older adults and those on corticosteroids.","May cause peripheral neuropathy; report tingling or numbness promptly.","Can cause central nervous system effects including dizziness, confusion, and seizures.","May worsen muscle weakness in myasthenia gravis.","Avoid excessive sunlight and tanning beds due to photosensitivity risk.","May cause hypoglycemia in diabetic patients; monitor blood sugar.","Do not use for viral infections; it is ineffective and promotes resistance.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding. Both ciprofloxacin and tinidazole pass into breast milk and may affect the infant. If treatment is essential, breastfeeding should be interrupted during therapy and for at least 72 hours after the last dose.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, dizziness, and in severe cases, seizures or heart rhythm disturbances. There is no specific antidote. Treatment is supportive and symptomatic. Seek immediate medical attention. Activated charcoal may be considered if the overdose is recent. Monitor vital signs, ECG, and electrolytes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine only when prescribed by a qualified clinician, and complete the full course even if you feel better after a few days. Swallow the tablet whole with a full glass of water, and take it with food to reduce stomach upset. Do not drink alcohol during treatment and for at least 72 hours after the last dose, because tinidazole can cause a severe reaction with alcohol. Avoid taking antacids, dairy products, or iron and zinc supplements within two hours before or after this medicine, as they can reduce ciprofloxacin absorption. Use effective contraception during treatment. Do not drive or operate heavy machinery if you feel dizzy. Tell your doctor about all other medicines you take, especially blood thinners, diabetes medicines, and heart rhythm drugs. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney impairment, and central nervous system effects. Dose adjustment based on renal function is often needed. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Discuss alternative treatments with your doctor. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if there is a risk of mixed bacterial infection. Follow your surgeon's instructions regarding dosing and duration. Monitor for signs of infection.
🦷 Dental Procedures
This medicine may be prescribed for dental infections. Inform your dentist if you are taking this medicine before any dental procedure. It does not replace proper dental care.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are unwell, especially if you have fever or diarrhoea. If you experience tendon pain, stop exercising and consult your doctor immediately.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take time off if you have severe diarrhoea or fever.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if you feel better. If you experience serious side effects such as tendon pain, severe diarrhoea, or allergic reactions, stop immediately and seek medical help.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, gut flora imbalance, and rare but serious effects such as tendon damage, nerve damage, and liver injury. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be needed if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhoea.
Evidence: Well-establishedMay help restore gut flora after antibiotic treatment.
Evidence: ModerateBased on culture and sensitivity, a narrower antibiotic may be preferable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as typhoid vaccine. Avoid live vaccines during treatment and for at least 24 hours after the last dose. Consult your doctor for timing of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing times gradually under medical advice. Declare it at customs if required. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but you must complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset. Avoid dairy products within 2 hours of the dose.
A: If you remember within half the dosing interval, take it. Otherwise, skip it and continue your regular schedule. Do not double dose.
A: No, alcohol must be strictly avoided during treatment and for 72 hours after the last dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure any stomach infection.
Fact: This medicine only works against specific bacteria and parasites. It is not effective for viral infections or all types of stomach upset. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent the infection from returning and to avoid antibiotic resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe reaction with tinidazole. Avoid alcohol completely during and for 72 hours after treatment. - Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children unless specifically prescribed by a specialist.
🔄 Alternative Options
Generic Alternatives
- Ciprofloxacin 500 mg + Tinidazole 250 mg tablet (various manufacturers)
Brand Alternatives
- Ciprolac TZ 500mg/250mg Tablet