Agvert 15mg/20mg Tablet: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Irregular heartbeat or fainting
If experiencing severe symptoms, call emergency services immediately.
What is cinaz d 15mg/20mg tablet used for?
This medicine is a combination of Domperidone and Cinnarizine used to treat vertigo, nausea, vomiting, and motion sickness. It works by blocking dopamine and histamine receptors and calcium channels to reduce dizziness and nausea.
- Generic Name: Domperidone + Cinnarizine
- Manufacturer: Orange Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cinaz d 15mg/20mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और सिनारिज़ीन का संयोजन है, जिसका उपयोग चक्कर आना (वर्टिगो), मतली, उल्टी और मोशन सिकनेस के इलाज के लिए किया जाता है। यह वेस्टिबुलर विकारों से जुड़े लक्षणों को कम करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, थकान, सिरदर्द और पेट में असहजता शामिल हैं। दुर्लभ मामलों में मांसपेशियों में अकड़न, कंपन, या दिल की धड़कन में गड़बड़ी हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे खाली पेट न लें, भोजन के साथ लें। दवा लेने के बाद वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 cinaz d 15mg/20mg tablet Uses & Benefits
[{"condition":"Vertigo","description":"Relieves spinning sensation and dizziness associated with vestibular disorders.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Prevents and treats nausea and vomiting of various origins, including motion sickness.","evidence":"Well-established"},{"condition":"Meniere's disease","description":"Helps control vertigo attacks and associated nausea in Meniere's disease.","evidence":"Moderate"},{"condition":"Motion sickness","description":"Prevents nausea, vomiting, and dizziness caused by motion during travel.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine-associated vertigo","description":"Sometimes prescribed off-label to reduce vertigo during migraine attacks.","evidence":"Limited"},{"condition":"Gastroparesis","description":"Domperidone component may be used off-label to improve gastric emptying in diabetic gastroparesis.","evidence":"Limited"}]
Primary treatment for: Vertigo
Also treats: Nausea and vomiting, Motion sickness, Meniere's disease
📋 Drug Information
| Generic Name(s) | Domperidone + Cinnarizine |
| Brand Name | Agvert 15mg/20mg Tablet |
| Manufacturer | Orange Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antiemetic and Antivertigo |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and enhances gastric motility and emptying. Cinnarizine is a calcium channel blocker and histamine H1 receptor antagonist that reduces vestibular excitability by inhibiting calcium influx into vestibular hair cells and blocking histamine receptors in the vestibular nuclei. Together, they reduce nausea, vomiting, and vertigo.
Mechanism Steps
💡 How to Take cinaz d 15mg/20mg tablet
Strength: Each immediate-release tablet contains Domperidone 15 mg and Cinnarizine 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally one to three times daily, depending on the condition being treated and the severity of symptoms. For vertigo, it is often taken twice daily. For motion sickness, it is taken 30 minutes before travel. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and extrapyramidal symptoms. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. Use with caution and consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (45 mg Domperidone and 60 mg Cinnarizine) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cinaz d 15mg/20mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Erythromycin | Major | |
| Amiodarone | Major | |
| Anticholinergics | Moderate | |
| CNS depressants | Moderate | |
| Levodopa | Moderate | |
| Grapefruit juice | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Ketoconazole
- Erythromycin
- Amiodarone
⚡ Moderate Interactions
- Anticholinergic drugs
- CNS depressants
- Levodopa
🍷 Alcohol Interaction
Alcohol may increase the sedative effects of Cinnarizine and Domperidone, leading to enhanced drowsiness and dizziness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Domperidone or Cinnarizine","Prolactin-releasing pituitary tumor (prolactinoma)","Gastrointestinal obstruction, perforation, or bleeding","Severe hepatic impairment","Parkinson's disease","Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)","Known QT prolongation or family history of long QT syndrome"]
⚠️ Warnings & Precautions
["Use with caution in patients with cardiac disease or electrolyte abnormalities.","Avoid use in patients with Parkinson's disease due to risk of worsening symptoms.","May cause drowsiness; avoid driving or operating machinery until effects are known.","Do not use for prolonged periods without medical supervision.","Use with caution in elderly patients due to increased risk of side effects.","Consult doctor before use in pregnancy or breastfeeding.","Avoid alcohol consumption while taking this medicine."]
🤱 Lactation Safety
Domperidone is excreted in breast milk. Cinnarizine may also pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor ECG and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid consuming alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you have heart problems, liver disease, kidney disease, or Parkinson's disease before starting this medicine. Do not use this medicine for long periods without medical supervision, as prolonged use of Domperidone can increase the risk of serious heart rhythm problems. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to side effects such as drowsiness, confusion, and extrapyramidal symptoms. Use with caution and lower doses may be appropriate. Regular monitoring is recommended.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, especially if you have undergone gastrointestinal surgery, as Domperidone affects gastric motility.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental problems. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid activities that require balance and coordination, such as cycling or climbing, until you know how this medicine affects you. Gentle exercises like walking may be safe, but consult your doctor first.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine abruptly without consulting your doctor. If you experience serious side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on whether to stop or adjust the dose.
📅 Long-Term Use Effects
Long-term use of this medicine, especially Domperidone, may increase the risk of extrapyramidal symptoms and cardiac arrhythmias. Regular monitoring of heart rhythm and neurological symptoms is advised. It should not be used for prolonged periods without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Exercises to improve balance and reduce vertigo symptoms.
Evidence: Well-establishedA series of head movements to treat benign paroxysmal positional vertigo.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from moisture. If crossing time zones, adjust dosing times gradually under medical advice. For motion sickness, take the tablet 30 minutes before travel. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes for nausea and 1-2 hours for vertigo.
A: It is best taken with food to reduce stomach upset.
A: This medicine may cause drowsiness. Avoid driving until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for cinaz d 15mg/20mg tablet
View AllAlternative brands with exact same active ingredient:
-
domal cz 15mg/20mg tabletDigmedi Pvt Ltd ₹28.13 41.4% CHEAPER
-
cinerax-d 15mg/20mg tabletRax Health Care Pvt Ltd ₹31.88 33.6% CHEAPER
-
cinact d 15mg/20mg tabletActive Healthcare ₹32.81 31.6% CHEAPER
-
kandor cz 15mg/20mg tabletKalpataru Formulations Pvt Ltd ₹32.81 31.6% CHEAPER
-
spinil d 15 mg/20 mg tabletAlchemist Life Science Ltd ₹33.09 31.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of dizziness.
Fact: This medicine is specifically for vertigo and nausea related to vestibular disorders. It is not effective for all types of dizziness. - Myth: It is safe to take this medicine indefinitely.
Fact: Prolonged use of Domperidone can increase the risk of serious heart rhythm problems. It should only be used for short periods under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Cinnarizine combination tablets from other manufacturers
Brand Alternatives
- Vertin
- Stugeron
- Diziron
- Vertigon