cilnikem-beta 5 tablet - Uses, Price, Side Effects & Substitutes
What is cilnikem-beta 5 tablet used for?
Cilacar NB 5 Tablet (Nebivolol + Cilnidipine) is used to treat CARDIAC. It contains Nebivolol (5mg) + Cilnidipine (10mg), which Nebivolol: Selective beta-1 blocker with nitric oxide-mediated vasodilation; Cil. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nebivolol + Cilnidipine
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cilnikem-beta 5 tablet Uses & Benefits
Off-label uses: Chronic stable angina, Heart failure (nebivolol)
๐ Drug Information
| Generic Name(s) | Nebivolol + Cilnidipine |
| Brand Name | Cilacar NB 5 Tablet |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive (Beta-blocker + Calcium channel blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nebivolol: Selective beta-1 blocker with nitric oxide-mediated vasodilation; Cilnidipine: L-type and N-type calcium channel blocker.
Mechanism Steps
๐ก How to Take cilnikem-beta 5 tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cilnikem-beta 5 tablet
โ Common Side Effects
- Headache
- Dizziness
- Fatigue
- Edema
- Bradycardia
๐จ Serious Side Effects
- Heart block
- Severe hypotension
- Bronchospasm
- Hepatic injury
โ ๏ธ Rare Side Effects
- Thrombocytopenia
- Stevens-Johnson syndrome
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP2D6 inhibitors | Major | Increased nebivolol levels |
| CYP3A4 inhibitors | Major | Increased cilnidipine levels |
| Other antihypertensives | Major | Additive hypotension |
| Digoxin | Moderate | Increased bradycardia risk |
| Warfarin | Moderate | Increased INR |
| Insulin/oral hypoglycemics | Moderate | Masked hypoglycemia symptoms |
| Cimetidine | Minor | Slight increase in nebivolol levels |
| Grapefruit juice | Minor | Increased cilnidipine absorption |
๐จ Major Interactions
- CYP2D6 inhibitors (e.g., quinidine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- Other antihypertensives (additive hypotension)
โก Moderate Interactions
- Digoxin
- Warfarin
- Insulin/oral hypoglycemics
โน๏ธ Minor Interactions
- Cimetidine
- Grapefruit juice
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase cilnidipine levels.
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Sick sinus syndrome, heart block (2nd/3rd degree), cardiogenic shock, severe bradycardia, hypersensitivity.
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, blood glucose (in diabetics).
๐คฑ Lactation Safety
Not recommended; avoid breastfeeding.
๐ Overdose Management
Symptomatic and supportive; monitor ECG, blood pressure; consider atropine for bradycardia.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double.