Altonil Plus 10 Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Slow, shallow, or difficulty breathing
- Severe drowsiness or confusion
- Swelling of face, lips, tongue, or throat
- Chest pain or irregular heartbeat
- Hallucinations or severe agitation
- Yellowing of skin or eyes
- Unusual bruising or bleeding
- Difficulty passing urine
If experiencing severe symptoms, call emergency services immediately.
What is altonil plus 10 tablet used for?
This medicine is a combination of Melatonin 10 mg and Clonazepam 0.5 mg used for the short-term treatment of insomnia, especially when anxiety or circadian rhythm disturbances are involved. It works by regulating sleep-wake cycles and enhancing GABA-mediated sedation. It should be taken exactly as prescribed, usually at bedtime, and must not be combined with alcohol or other sedatives.
- Generic Name: Melatonin + Clonazepam
- Manufacturer: Alteus Biogenics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 altonil plus 10 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेलाटोनिन 10 मिलीग्राम और क्लोनाजेपाम 0.5 मिलीग्राम का संयोजन है, जिसका उपयोग अनिद्रा (नींद न आने) के अल्पकालिक उपचार के लिए किया जाता है, विशेष रूप से जब चिंता या शरीर की आंतरिक घड़ी में गड़बड़ी के कारण नींद न आती हो। यह दवा नींद चक्र को नियमित करने और मस्तिष्क में शांति पैदा करने वाले रसायन GABA के प्रभाव को बढ़ाने में मदद करती है। इसे डॉक्टर के निर्देशानुसार, आमतौर पर सोने से पहले एक बार लेना चाहिए। इस दवा को शराब या अन्य नींद लाने वाली दवाओं के साथ नहीं लेना चाहिए। इसका उपयोग केवल थोड़े समय के लिए करना चाहिए और इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दिन में नींद आना, चक्कर आना, थकान, सिरदर्द, और सुबह उठने पर सुस्ती महसूस होना शामिल है। कुछ लोगों को मुँह सूखना, धुंधली दृष्टि, मतली, या हल्की भ्रम की स्थिति हो सकती है। गंभीर लेकिन दुर्लभ दुष्प्रभावों में सांस लेने में कठिनाई, याददाश्त में कमी, मनोदशा में बदलाव, और गंभीर एलर्जी प्रतिक्रियाएँ शामिल हैं। लंबे समय तक उपयोग से निर्भरता और छोड़ने पर लक्षण उत्पन्न हो सकते हैं। किसी भी असामान्य या लगातार बने रहने वाले दुष्प्रभाव की सूचना तुरंत अपने डॉक्टर को दें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें, आमतौर पर सोने से पहले एक बार। गोली को चबाएं या तोड़ें नहीं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या भारी मशीनरी चलाने से बचें। इस दवा के साथ शराब का सेवन बिल्कुल न करें। लंबे समय तक उपयोग के बाद इसे अचानक बंद न करें, क्योंकि इससे छोड़ने के लक्षण हो सकते हैं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को सूचित करें। इस दवा को बच्चों की पहुंच से दूर, ठंडी और सूखी जगह पर रखें।
💊 altonil plus 10 tablet Uses & Benefits
[{"condition":"Insomnia","description":"This medicine helps reduce the time taken to fall asleep and improves sleep duration in people with difficulty initiating or maintaining sleep, especially when associated with anxiety or circadian rhythm disturbances.","evidence":"Moderate"},{"condition":"Anxiety-related sleep disturbances","description":"The clonazepam component helps reduce anxiety that interferes with sleep, while melatonin helps reset the sleep-wake cycle.","evidence":"Moderate"},{"condition":"Rapid eye movement sleep behavior disorder","description":"Clonazepam is sometimes used off-label for this condition, but the combination with melatonin is not standard.","evidence":"Limited"},{"condition":"Jet lag","description":"Melatonin can help with jet lag, but the addition of clonazepam is not routinely recommended due to sedation risk.","evidence":"Limited"}]
Off-label uses: [{"condition":"Seizure disorders","description":"Clonazepam is used off-label as an adjunct in some seizure types, but the combination with melatonin is not established.","evidence":"Limited"},{"condition":"Panic disorder","description":"Clonazepam may be used off-label for panic attacks, but melatonin addition is not standard.","evidence":"Limited"}]
Primary treatment for: Insomnia
Also treats: Anxiety disorders, Circadian rhythm sleep disorders, Jet lag, Restless legs syndrome
📋 Drug Information
| Generic Name(s) | Melatonin + Clonazepam |
| Brand Name | Altonil Plus 5 Tablet |
| Manufacturer | Alteus Biogenics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Hypnotic and Sedative |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture. Do not use beyond the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Melatonin acts on MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus to regulate circadian rhythms and promote sleep onset. Clonazepam enhances the inhibitory effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, leading to increased chloride ion influx, neuronal hyperpolarization, and reduced excitability in the central nervous system. Together, they produce sedation, anxiolysis, muscle relaxation, and sleep promotion.
Mechanism Steps
💡 How to Take altonil plus 10 tablet
Strength: Tablet containing Melatonin 10 mg and Clonazepam 0.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily at bedtime. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. This medicine is intended for short-term use only. Long-term use should be avoided unless specifically advised by a specialist. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine. A lower starting dose is recommended, and the dose should be titrated slowly. Close monitoring for sedation, falls, and respiratory depression is advised. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. However, caution is advised in patients with severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine should be used with caution in patients with mild to moderate hepatic impairment. It is contraindicated in severe hepatic impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of this medicine is one tablet (Melatonin 10 mg + Clonazepam 0.5 mg). Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of altonil plus 10 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Ketoconazole | Major | |
| Fluvoxamine | Moderate | |
| Antihypertensives | Moderate | |
| SSRIs | Moderate | |
| Oral contraceptives | Moderate | |
| Cimetidine | Minor | |
| Rifampicin | Minor | |
| Caffeine | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
⚡ Moderate Interactions
- Antihypertensives
- Antidepressants (e.g., SSRIs, MAOIs)
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both alcohol and this medicine are central nervous system depressants. Combining them can lead to severe drowsiness, respiratory depression, coma, and even death. Even small amounts of alcohol can enhance the sedative effects and impair your ability to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to melatonin, clonazepam, or any component of the formulation","Severe hepatic impairment","Severe respiratory insufficiency","Myasthenia gravis","Acute narrow-angle glaucoma","Sleep apnea syndrome","Pregnancy and breastfeeding (unless clearly necessary)","Children under 18 years of age (safety and efficacy not established)"]
⚠️ Warnings & Precautions
["This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you.","Do not consume alcohol while taking this medicine due to the risk of severe CNS depression.","Long-term use can lead to tolerance, dependence, and withdrawal symptoms. Use for the shortest duration possible.","Do not stop this medicine abruptly after prolonged use. Taper gradually under medical supervision.","Use with caution in elderly patients due to increased risk of falls, confusion, and respiratory depression.","Inform your doctor if you have a history of substance abuse, as this medicine has a potential for abuse.","This medicine may cause memory impairment. Report any persistent memory problems to your doctor.","Avoid taking this medicine if you have sleep apnea or other breathing problems."]
🤱 Lactation Safety
Clonazepam is excreted in breast milk and may cause sedation and feeding difficulties in the infant. Melatonin also passes into breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, respiratory depression, coma, and death. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage, activated charcoal, and flumazenil (a benzodiazepine antagonist) for clonazepam toxicity. Melatonin overdose is generally less severe but can cause excessive sedation. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is still close to your scheduled bedtime. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily at bedtime. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause significant drowsiness. Do not drink alcohol while taking this medicine, as it can increase sedation and impair breathing. Do not stop this medicine suddenly after prolonged use, as it can cause withdrawal symptoms such as anxiety, tremors, and insomnia. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, including sedation, dizziness, and confusion. They are at higher risk of falls, fractures, and respiratory depression. A lower starting dose is recommended, and the dose should be titrated slowly. Regular monitoring for cognitive and motor impairment is advised. This medicine should be used with caution in elderly patients, and non-drug therapies should be considered first.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Clonazepam may cause fetal harm, and melatonin's effects on pregnancy are not well studied. Your doctor may recommend alternative treatments for insomnia. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
This medicine can increase the risk of respiratory depression and excessive sedation after surgery, especially when combined with anesthetic agents or opioid painkillers. Inform your surgeon and anesthesiologist about this medicine before any surgical procedure. It may need to be temporarily discontinued before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it can interact with sedatives or anesthetics used during dental procedures, leading to excessive drowsiness. Your dentist may adjust the dosage of other medications or take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may increase the risk of falls or injuries during exercise. Avoid high-intensity or balance-demanding exercises until you know how the medicine affects you. Light to moderate exercise earlier in the day is generally safe and can improve sleep quality.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness, dizziness, and impaired coordination, which may affect your ability to work, drive, or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks. The sedative effects may also impact your productivity and concentration during the day.
🛑 When to Stop This Medicine
You should stop this medicine only under your doctor's supervision. If you have been taking it for more than a few weeks, your doctor will likely recommend a gradual tapering schedule to prevent withdrawal symptoms. Do not stop abruptly. If you experience side effects or your sleep improves, consult your doctor about discontinuing the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning you may need higher doses to achieve the same effect. It can also cause physical and psychological dependence, with withdrawal symptoms such as anxiety, insomnia, tremors, and seizures if stopped abruptly. Prolonged use may affect memory, cognition, and mood. Regular monitoring by a doctor is essential, and the medicine should be used for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured program that helps change sleep habits and thoughts that interfere with sleep.
Evidence: Well-establishedPractices and habits that promote consistent, uninterrupted sleep.
Evidence: Well-establishedDeep breathing, progressive muscle relaxation, and meditation can help reduce anxiety and improve sleep.
Evidence: ModerateFor some patients, melatonin alone may be sufficient without the risks of clonazepam.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider about all medications you are taking. It is generally safe to continue this medicine before and after vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not share with others
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. If crossing time zones, consult your doctor about adjusting the timing of your dose to match your new sleep schedule. Store the medicine in a cool, dry place, away from direct sunlight. Keep it in your carry-on luggage to avoid loss or temperature extremes. Check local customs regulations regarding controlled substances, as clonazepam may be regulated in some countries. Always declare your medication if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking it. You should feel sleepy and ready for bed within that time.
A: This medicine is intended for short-term use only. Long-term use can lead to tolerance and dependence. Consult your doctor if you need it for more than a few weeks.
A: If you miss a dose, take it as soon as you remember if it is still close to bedtime. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, this medicine can cause significant drowsiness and impair your ability to drive or operate machinery. Avoid driving until you know how it affects you.
A: No, stopping this medicine suddenly after prolonged use can cause withdrawal symptoms. Always consult your doctor for a gradual tapering plan.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a natural sleep aid and is completely safe.
Fact: This medicine contains clonazepam, a benzodiazepine that can cause dependence, withdrawal, and serious side effects. It is not a harmless natural supplement. - Myth: I can take this medicine whenever I have trouble sleeping.
Fact: This medicine is a prescription drug and should only be taken under medical supervision for a specified duration. Self-medication can be dangerous. - Myth: This medicine is safe to take with alcohol.
Fact: Combining this medicine with alcohol can cause severe respiratory depression, coma, and death. Alcohol must be strictly avoided. - Myth: I can stop this medicine abruptly once I feel better.
Fact: Abrupt discontinuation can cause withdrawal symptoms such as anxiety, tremors, and rebound insomnia. Always taper gradually under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Melatonin 10 mg + Clonazepam 0.5 mg tablet (various manufacturers)
Brand Alternatives
- Altonil Plus 10 Tablet