chymofast-d tablet - Diclofenac (50mg) + Trypsin Chymotrypsin (50000IU) medicine

chymofast-d tablet

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🏭 Axis Labs Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is chymofast-d tablet used for?

This medicine contains Diclofenac (50mg) + Trypsin Chymotrypsin (50000IU) and is used to treat PAIN ANALGESICS. Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Trypsin Chym. Always consult your doctor before use.

  • Generic Name: Diclofenac + Trypsin Chymotrypsin
  • Manufacturer: Axis Labs Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 chymofast-d tablet Uses & Benefits

Pain and inflammation associated with trauma, surgery, dental procedures, musculoskeletal disorders.

Off-label uses: Not well documented.

📋 Drug Information

Generic Name(s)Diclofenac + Trypsin Chymotrypsin
Brand NameChymoral Plus
ManufacturerAxis Labs Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Proteolytic Enzymes
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac: Rapidly and completely absorbed from GI tract; Trypsin Chymotrypsin: Absorbed as intact enzymes via intestinal mucosa.
DistributionDiclofenac: Highly protein-bound (>99%), distributed to synovial fluid; Trypsin Chymotrypsin: Distributed to inflamed tissues.
Protein BindingDiclofenac: >99%
MetabolismDiclofenac: Hepatic via CYP2C9; Trypsin Chymotrypsin: Metabolized locally in tissues.
Half-LifeDiclofenac: ~2 hours; Trypsin Chymotrypsin: Not well defined.
ExcretionDiclofenac: Renal (65%) and biliary (35%); Trypsin Chymotrypsin: Excreted as inactive metabolites.
BioavailabilityDiclofenac: ~50% (oral); Trypsin Chymotrypsin: Low systemic bioavailability.
Onset of ActionDiclofenac: 30-60 minutes; Trypsin Chymotrypsin: Within hours.
Peak Plasma TimeDiclofenac: 1-2 hours; Trypsin Chymotrypsin: Not well defined.
Duration of ActionDiclofenac: 6-8 hours; Trypsin Chymotrypsin: Up to 24 hours.

How It Works

Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Trypsin Chymotrypsin hydrolyzes proteins involved in inflammation and edema.

Mechanism Steps

1Diclofenac inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis.
2Decreased prostaglandins lead to reduced inflammation, pain, and fever.
3Trypsin Chymotrypsin hydrolyzes proteins in inflammatory exudates, reducing edema.
4Enzymatic breakdown of fibrin and other proteins promotes resolution of swelling.

💡 How to Take chymofast-d tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of chymofast-d tablet

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Dyspepsia
Abdominal pain
Headache
Dizziness
Rash

🚨 Serious Side Effects

GI bleeding
Peptic ulcer
Renal failure
Hepatotoxicity
Anaphylaxis
Stevens-Johnson syndrome
Cardiovascular thrombotic events

⚠️ Rare Side Effects

Pancreatitis
Aseptic meningitis
Hematologic disorders
Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Lithium Major Increased lithium toxicity
Methotrexate Major Increased methotrexate toxicity
Aspirin Major Increased GI ulceration risk
Other NSAIDs Major Additive GI and renal toxicity
Anticoagulants Major Increased bleeding risk
Corticosteroids Major Increased GI ulceration risk
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect, increased nephrotoxicity
Cyclosporine Moderate Increased nephrotoxicity
Tacrolimus Moderate Increased nephrotoxicity
Quinolone antibiotics Moderate Increased risk of seizures
Antacids Minor Reduced absorption of Diclofenac
Digoxin Minor Increased digoxin levels
Phenytoin Minor Increased phenytoin levels

🚨 Major Interactions

  • Warfarin
  • Lithium
  • Methotrexate
  • Aspirin
  • Other NSAIDs
  • Anticoagulants
  • Corticosteroids

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Cyclosporine
  • Tacrolimus
  • Quinolone antibiotics

🍷 Alcohol Interaction

Increased risk of GI bleeding and hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, active GI bleeding, severe renal/hepatic impairment, history of asthma with NSAIDs, third trimester pregnancy.

🤱 Lactation Safety

Excreted in breast milk; avoid or use with caution.

💊 Overdose Management

Symptomatic and supportive; gastric lavage, activated charcoal; monitor for GI bleeding, renal failure.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose.

🔄 Substitutes for chymofast-d tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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