chlorzen 6.25mg tablet - Chlorthalidone (6.25mg) medicine

chlorzen 6.25mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Innovative Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is chlorzen 6.25mg tablet used for?

ctd 6.25 tablet (Chlorthalidone) is used to treat CARDIAC. It contains Chlorthalidone (6.25mg), which Inhibits sodium-chloride symporter in distal convoluted tubule, increasing excre. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Chlorthalidone
  • Manufacturer: Innovative Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š chlorzen 6.25mg tablet Uses & Benefits

Hypertension, Edema associated with congestive heart failure, cirrhosis, or renal disease

Off-label uses: Nephrolithiasis (calcium stones), Diabetes insipidus

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorthalidone
Brand Namectd 6.25 tablet
ManufacturerInnovative Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassLow-ceiling Diuretics (Inhibitors of Na+Cl symport)
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed slowly from the gastrointestinal tract; bioavailability approximately 65%.
DistributionDistributes widely; crosses placenta; enters breast milk.
Protein BindingApproximately 75% bound to plasma proteins, mainly albumin.
MetabolismMinimally metabolized; primarily excreted unchanged.
Half-Life40-60 hours
ExcretionPrimarily renal (50-65% unchanged); some biliary excretion.
BioavailabilityApproximately 65%
Onset of Action2-6 hours
Peak Plasma Time2-4 hours
Duration of Action24-72 hours

How It Works

Inhibits sodium-chloride symporter in distal convoluted tubule, increasing excretion of sodium, chloride, and water.

Mechanism Steps

1Chlorthalidone binds to the sodium-chloride cotransporter (NCC) in the distal convoluted tubule of the nephron.
2Inhibition of NCC reduces reabsorption of sodium and chloride from the tubular fluid.
3Increased sodium and chloride in the tubular lumen create an osmotic gradient, drawing water into the tubule.

๐Ÿ’ก How to Take chlorzen 6.25mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of chlorzen 6.25mg tablet

โœ… Common Side Effects

  • Hypokalemia
  • Hyperuricemia
  • Dizziness
  • Headache
  • Fatigue
  • Nausea

๐Ÿšจ Serious Side Effects

  • Severe hypokalemia
  • Arrhythmias
  • Pancreatitis
  • Hepatic encephalopathy
  • Stevens-Johnson syndrome

โš ๏ธ Rare Side Effects

  • Thrombocytopenia
  • Leukopenia
  • Photosensitivity
  • Acute angle-closure glaucoma

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Lithium Major Increased lithium levels and toxicity risk
NSAIDs Major Reduced diuretic efficacy and increased nephrotoxicity risk
Corticosteroids Major Increased risk of hypokalemia
Amphotericin B Major Increased risk of hypokalemia and nephrotoxicity
Digoxin Moderate Increased risk of digoxin toxicity due to hypokalemia
Antidiabetic agents Moderate May decrease glucose tolerance; adjust doses
Antihypertensives Moderate Additive hypotensive effect
Cholestyramine Moderate Reduced absorption of chlorthalidone
Calcium supplements Minor Possible hypercalcemia
Vitamin D Minor Possible hypercalcemia

๐Ÿšจ Major Interactions

  • Lithium
  • NSAIDs
  • Corticosteroids
  • Amphotericin B

โšก Moderate Interactions

  • Digoxin
  • Antidiabetic agents
  • Antihypertensives
  • Cholestyramine

โ„น๏ธ Minor Interactions

  • Calcium supplements
  • Vitamin D

๐Ÿฝ๏ธ Food Interactions

High sodium intake may reduce efficacy; avoid excessive potassium-rich foods if hypokalemia risk.

๐Ÿท Alcohol Interaction

May potentiate orthostatic hypotension; avoid excessive alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Anuria, Hypersensitivity to chlorthalidone or sulfonamides, Severe renal impairment (CrCl <30 mL/min), Hepatic coma or pre-coma

๐Ÿ“Š Monitoring Parameters

Blood pressure, Serum electrolytes (especially potassium), Renal function, Blood glucose, Uric acid levels

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution, monitor infant for electrolyte disturbances.

๐Ÿ’Š Overdose Management

Induce emesis or gastric lavage; monitor electrolytes, hydration, and renal function; treat hypotension with fluids and vasopressors if needed.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for chlorzen 6.25mg tablet

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Alternative brands with exact same active ingredient (Chlorthalidone (6.25mg)):

Medical Note: Always consult your doctor before switching medications.

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