childryl syrup - Promethazine (1.5mg/5ml) + Pholcodine (1.5mg/5ml) medicine

childryl syrup

4.5 (14 reviews)
๐Ÿญ Mandar Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is childryl syrup used for?

Childryl Syrup (Promethazine + Pholcodine) is used to treat RESPIRATORY. It contains Promethazine (1.5mg/5ml) + Pholcodine (1.5mg/5ml), which Promethazine blocks histamine H1 receptors, reducing allergic symptoms; Pholcodi. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Promethazine + Pholcodine
  • Manufacturer: Mandar Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š childryl syrup Uses & Benefits

Allergic cough, dry cough, urticaria, motion sickness, sedation

Off-label uses: Nausea and vomiting, Preoperative sedation

๐Ÿ“‹ Drug Information

Generic Name(s)Promethazine + Pholcodine
Brand NameChildryl Syrup
ManufacturerMandar Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntitussive + Antihistamine
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from gastrointestinal tract
DistributionDistributed throughout body, crosses blood-brain barrier
Protein BindingPromethazine: 76-93%; Pholcodine: not extensively bound
MetabolismPromethazine: Hepatic via CYP2D6; Pholcodine: Hepatic
Half-LifePromethazine: 10-14 hours; Pholcodine: 2-4 hours
ExcretionRenal (urine) and biliary (feces)
BioavailabilityPromethazine: ~25% oral; Pholcodine: ~50% oral
Onset of Action20-30 minutes
Peak Plasma TimePromethazine: 2-3 hours; Pholcodine: 1-2 hours
Duration of Action4-6 hours

How It Works

Promethazine blocks histamine H1 receptors, reducing allergic symptoms; Pholcodine suppresses cough by acting on cough center in medulla

Mechanism Steps

1Promethazine binds to H1 receptors, blocking histamine action
2Reduces allergic symptoms and sedation via central H1 blockade
3Pholcodine acts on ฮผ-opioid receptors in cough center

๐Ÿ’ก How to Take childryl syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of childryl syrup

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Blurred vision
  • Constipation

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Severe hypotension
  • Extrapyramidal symptoms
  • QT prolongation

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Photosensitivity
  • Cholestatic jaundice

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
CNS depressants Major Enhanced sedation and respiratory depression
MAO inhibitors Major Increased anticholinergic and sedative effects
Anticholinergics Major Additive anticholinergic effects
Antihypertensives Moderate Enhanced hypotensive effect
Antipsychotics Moderate Increased risk of extrapyramidal symptoms
Tricyclic antidepressants Moderate Increased anticholinergic and sedative effects
Antacids Minor May reduce absorption of promethazine
Alcohol Minor Increased CNS depression

๐Ÿšจ Major Interactions

  • CNS depressants
  • MAO inhibitors
  • Anticholinergics

โšก Moderate Interactions

  • Antihypertensives
  • Antipsychotics
  • Tricyclic antidepressants

โ„น๏ธ Minor Interactions

  • Antacids
  • Alcohol

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase absorption

๐Ÿท Alcohol Interaction

Increased CNS depression and sedation

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, severe hypertension, coronary artery disease, MAOI use within 14 days, children <2 years, respiratory depression, asthma attack

๐Ÿ“Š Monitoring Parameters

Respiratory rate, sedation level, blood pressure, heart rate, anticholinergic effects

๐Ÿคฑ Lactation Safety

Not recommended; may cause sedation in infant

๐Ÿ’Š Overdose Management

Activated charcoal, supportive care, monitor respiratory and cardiac function; physostigmine for severe anticholinergic symptoms

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

๐Ÿ˜Š Was this information helpful?

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