chemobine 1gm injection

4.7 (11 reviews)

Gemcitabine (1gm)

🏭 Cytogen Pharmaceuticals India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is chemobine 1gm injection used for?

Abigem 200mg Injection (Gemcitabine) is used to treat ANTI NEOPLASTICS. It contains Gemcitabine (1gm), which Gemcitabine is a nucleoside analog that inhibits DNA synthesis by incorporating . Always consult your doctor before use. Take as prescribed.

Generic Name: Gemcitabine
Manufacturer: Cytogen Pharmaceuticals India Pvt Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 chemobine 1gm injection Uses & Benefits

Non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer, ovarian cancer.

Off-label uses: Hepatocellular carcinoma, lymphoma, sarcoma.

📋 Drug Information

Generic Name(s)	Gemcitabine
Brand Name	Abigem 200mg Injection
Manufacturer	Cytogen Pharmaceuticals India Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Antimetabolites
Route of Administration	Intravenous infusion
Storage	Store at 20-25°C (68-77°F); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionGemcitabine is administered intravenously, resulting in complete bioavailability.

DistributionWidely distributed into body tissues, including tumors. Volume of distribution is approximately 50 L/m².

Protein BindingNegligible (<10%)

MetabolismMetabolized intracellularly by deoxycytidine kinase to active diphosphate and triphosphate metabolites; also deaminated by cytidine deaminase to inactive metabolite.

Half-LifeShort initial half-life (8-17 minutes); terminal half-life of active triphosphate is 1.7-19.4 hours.

ExcretionPrimarily renal (92-98% as unchanged drug and metabolites).

Bioavailability100% (IV administration)

Onset of ActionRapid; cytotoxic effects begin within hours.

Peak Plasma TimeImmediately after infusion (IV).

Duration of ActionCytotoxic effects persist for days; dosing typically weekly.

How It Works

Gemcitabine is a nucleoside analog that inhibits DNA synthesis by incorporating into DNA and inhibiting ribonucleotide reductase.

Mechanism Steps

1Gemcitabine enters cells via nucleoside transporters.

2Phosphorylated by deoxycytidine kinase to gemcitabine monophosphate.

3Further phosphorylated to active diphosphate and triphosphate metabolites.

💡 How to Take chemobine 1gm injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of chemobine 1gm injection

✅ Common Side Effects

Nausea
Vomiting
Fatigue
Fever
Myelosuppression
Alopecia

🚨 Serious Side Effects

Severe myelosuppression
Pulmonary toxicity
Hemolytic uremic syndrome
Hepatotoxicity

⚠️ Rare Side Effects

Capillary leak syndrome
Posterior reversible encephalopathy syndrome
Cardiotoxicity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased INR and bleeding risk
Live vaccines	Major	Risk of disseminated infection
Bleomycin	Major	Increased pulmonary toxicity
Methotrexate	Moderate	Increased toxicity
Cisplatin	Moderate	Enhanced myelosuppression
Radiation therapy	Moderate	Increased radiation toxicity
Acetaminophen	Minor	Possible hepatotoxicity
Digoxin	Minor	Decreased digoxin levels

🚨 Major Interactions

Warfarin
Live vaccines
Bleomycin

⚡ Moderate Interactions

Methotrexate
Cisplatin
Radiation therapy

ℹ️ Minor Interactions

Acetaminophen
Digoxin

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

Avoid alcohol due to increased hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to gemcitabine, severe bone marrow suppression, pregnancy.

📊 Monitoring Parameters

Complete blood count, liver function tests, renal function, pulmonary function.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote. Monitor for myelosuppression.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for chemobine 1gm injection

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Alternative brands with exact same active ingredient (Gemcitabine (1gm)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.