Citafine 1gm Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever above 38°C or chills
- Unexplained bleeding or bruising
- Shortness of breath or difficulty breathing
- Severe abdominal pain or vomiting
- Decreased urine output or swelling
- Yellowing of skin or eyes
- Severe headache with vision changes
- Rapid swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is chemobine 1gm injection used for?
This medicine is a chemotherapy drug given intravenously to treat several types of cancer, including lung, pancreatic, bladder, breast, and ovarian cancers. It works by blocking DNA synthesis in cancer cells, leading to their death. It must be administered by a healthcare professional and requires regular monitoring.
- Generic Name: Gemcitabine
- Manufacturer: Cytogen Pharmaceuticals India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 chemobine 1gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक कीमोथेरेपी एजेंट है जिसका उपयोग कई प्रकार के कैंसर के इलाज के लिए किया जाता है, जिनमें फेफड़ों का कैंसर, अग्नाशय का कैंसर, मूत्राशय का कैंसर, स्तन कैंसर और डिम्बग्रंथि का कैंसर शामिल हैं। यह दवा नस के माध्यम से दी जाती है और इसे एक योग्य चिकित्सक द्वारा ही दिया जाना चाहिए। यह कैंसर कोशिकाओं के विकास को रोककर उन्हें नष्ट करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, थकान, बुखार, दाने और फ्लू जैसे लक्षण शामिल हैं। गंभीर दुष्प्रभावों में अस्थि मज्जा का दमन, गुर्दे की समस्या, यकृत विषाक्तता और फेफड़ों की विषाक्तता शामिल हो सकती है। किसी भी असामान्य लक्षण को तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा एक नैदानिक सेटिंग में ही दी जानी चाहिए। नियमित रक्त परीक्षण आवश्यक हैं। उपचार के दौरान और उसके बाद कुछ महीनों तक प्रभावी गर्भनिरोधक का उपयोग करें। इस दवा के दौरान लाइव टीके न लगवाएं। संक्रमण, रक्तस्राव या असामान्य थकान के किसी भी लक्षण की तुरंत रिपोर्ट करें।
💊 chemobine 1gm injection Uses & Benefits
[{"condition":"Non-small cell lung cancer","description":"Used in combination with other chemotherapy agents for first-line treatment of advanced or metastatic non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Pancreatic cancer","description":"Approved for use as first-line treatment in combination with other agents for locally advanced or metastatic pancreatic cancer.","evidence":"Well-established"},{"condition":"Bladder cancer","description":"Used in combination with other drugs for advanced or metastatic bladder cancer.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Used in combination with other chemotherapy for metastatic breast cancer after failure of prior treatments.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Used in combination with other agents for advanced ovarian cancer that has recurred after platinum-based therapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Biliary tract cancer","description":"Sometimes used off-label in combination with other drugs for advanced biliary tract cancers.","evidence":"Limited"},{"condition":"Soft tissue sarcoma","description":"Occasionally used off-label for certain types of soft tissue sarcomas.","evidence":"Limited"}]
Primary treatment for: Various cancers including non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer, and ovarian cancer.
Also treats: Biliary tract cancer, Soft tissue sarcoma
📋 Drug Information
| Generic Name(s) | Gemcitabine |
| Brand Name | Abigem 200mg Injection |
| Manufacturer | Cytogen Pharmaceuticals India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolites |
| Route of Administration | Intravenous |
| Storage | Store vials at 20°C to 25°C (68°F to 77°F). Protect from light. Do not refrigerate. After reconstitution, the solution should be used immediately or stored as per institutional guidelines. |
| Shelf Life | Refer to the expiration date on the vial. Do not use after expiry. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a nucleoside analogue that inhibits DNA synthesis. After entering cells, it is phosphorylated to active diphosphate and triphosphate forms. The diphosphate inhibits ribonucleotide reductase, reducing deoxynucleotide pools needed for DNA synthesis. The triphosphate competes with deoxycytidine triphosphate for incorporation into DNA, leading to chain termination and inhibition of DNA synthesis, ultimately causing cell death.
Mechanism Steps
💡 How to Take chemobine 1gm injection
Strength: 1 gram per vial, powder for solution for injection.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the type of cancer, stage, combination with other drugs, and patient factors such as body surface area, renal and hepatic function. Common regimens include 1000 mg/m² intravenously over 30 minutes once weekly for several weeks, or other schedules. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially bone marrow suppression and kidney toxicity. Dose adjustments may be necessary based on renal and hepatic function. Close monitoring is recommended. |
| Renal Impairment | In patients with renal impairment, dose adjustments may be necessary. For moderate renal impairment (CrCl 30-50 mL/min), consider dose reduction. For severe renal impairment (CrCl <30 mL/min), use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, dose adjustments may be necessary. For mild to moderate impairment, no specific adjustment is recommended, but monitor closely. For severe impairment, use with caution. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | Not applicable; dosing is based on body surface area and schedule. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of chemobine 1gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Warfarin | Major | |
| Cisplatin | Moderate | |
| Radiation therapy | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Live vaccines
- Warfarin
⚡ Moderate Interactions
- Cisplatin
- Radiation therapy
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to gemcitabine or any component of the formulation","Pregnancy","Severe renal impairment","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Bone marrow suppression: May require dose reduction or delay.","Renal toxicity: Monitor kidney function; discontinue if severe.","Hepatic toxicity: Monitor liver function; discontinue if severe.","Pulmonary toxicity: Report new respiratory symptoms.","Cardiac toxicity: Use with caution in patients with heart disease.","Radiation recall: May occur in patients who have received prior radiation.","Immunosuppression: Avoid live vaccines."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least one week after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. Treatment should be symptomatic and supportive. Monitor blood counts, liver and kidney function closely. Dialysis may not be effective in removing the drug.
⏰ Missed Dose
This medicine is administered by a healthcare professional. If you miss an appointment for your dose, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional in a clinical setting. Regular blood tests are essential to monitor blood cell counts, kidney and liver function. Avoid contact with people who have infections. Use effective contraception during treatment and for several months after. Do not receive live vaccines while on this medicine. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Report any signs of infection, bleeding, or unusual fatigue immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially bone marrow suppression and kidney toxicity. Close monitoring and dose adjustments may be necessary.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Men should also use contraception for at least 3 months after treatment. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and infection after surgery. Inform your surgeon that you are receiving this medicine. Your doctor may recommend delaying surgery or adjusting the dose.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infection. Inform your dentist that you are receiving this medicine. Your dentist may recommend postponing elective dental procedures until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause fatigue and low blood counts. Avoid strenuous exercise and activities that increase the risk of bleeding or injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant fatigue, nausea, and increased infection risk. You may need to take time off work during treatment. Avoid operating heavy machinery or driving if you feel dizzy or tired. Discuss your work schedule with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment may be stopped or adjusted based on your response, side effects, or disease progression. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent bone marrow suppression, increased risk of infections, and organ toxicity. Regular monitoring of blood counts, liver and kidney function is essential. Some patients may experience long-term fatigue or neuropathy. Discuss any persistent symptoms with your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Drugs that target specific molecules involved in cancer growth.
Evidence: Well-established for certain cancersTreatments that boost the immune system to fight cancer.
Evidence: Well-established for certain cancersUse of high-energy rays to kill cancer cells.
Evidence: Well-established for certain cancers💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered in a clinical setting, so travel is not applicable. If you need to travel for treatment, carry your prescription and medical records. Store vials at room temperature and protect from light. Check with your doctor about scheduling doses around travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine on cancer cells begin soon after administration, but visible tumor shrinkage may take several weeks to months. Your doctor will monitor your response with regular scans and tests.
A: This medicine can cause fatigue and dizziness. It is advisable to arrange for someone else to drive you to and from your appointments until you know how it affects you.
A: This medicine can be harmful to a fetus. Avoid close contact with pregnant women, especially if you are handling bodily fluids. Use barrier protection during sexual activity.
🤔 Common Patient Concerns
🔄 Substitutes for chemobine 1gm injection
View AllAlternative brands with exact same active ingredient:
-
gembin 1gm injectionBiochem Pharmaceutical Industries ₹2,660.12 44.4% CHEAPER
-
gemtero 1gm injectionHetero Drugs Ltd ₹4,531.88 5.2% CHEAPER
-
gemwel 1gm injectionGetwell Pharmaceutical Pvt Ltd ₹5,160.00 7.9% COSTLIER
-
winogem 1gm injectionWockhardt Ltd ₹5,227.46 9.3% COSTLIER
-
gemcite 1gm injectionEli Lilly and Company India Pvt Ltd ₹5,235.00 9.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home.
Fact: This medicine must be administered by a healthcare professional in a clinical setting. - Myth: This medicine has no side effects.
Fact: This medicine can cause significant side effects, including bone marrow suppression and organ toxicity. - Myth: This medicine can cure all cancers.
Fact: This medicine is effective for specific types of cancer and is often used in combination with other treatments.
🔄 Alternative Options
Generic Alternatives
- Gemcitabine
Brand Alternatives
- Citafine 1gm injection