cetril d tablet - Ambroxol (50mg) + Levocetirizine (5mg) medicine

Cetril D Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Trident Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the combination in allergic cough; individual components have well-established evidence.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath
  • Swelling of face, lips, or throat
  • Severe dizziness or fainting
  • Fast or irregular heartbeat
  • Blood in sputum or vomit
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is cetril d tablet used for?

This medicine is a combination of Ambroxol (mucolytic) and Levocetirizine (antihistamine) used to treat productive cough with allergic symptoms. It thins mucus and reduces sneezing, runny nose, and watery eyes. It is usually taken once or twice daily as prescribed.

  • Generic Name: Ambroxol + Levocetirizine
  • Manufacturer: Trident Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cetril d tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एम्ब्रोक्सोल और लेवोसेटिरिज़ीन का संयोजन है, जिसका उपयोग बलगम वाली खांसी और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना और आंखों में पानी आना के इलाज के लिए किया जाता है। यह बलगम को पतला करती है और एलर्जी को कम करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, थकान और हल्का पेट दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या तेज़ धड़कन हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसके सेवन के दौरान वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको किडनी या लीवर की समस्या है, तो डॉक्टर को बताएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cetril d tablet Uses & Benefits

[{"condition":"Productive cough with allergic rhinitis","description":"This medicine helps loosen mucus and relieve allergic symptoms such as runny nose and sneezing, making it easier to cough out secretions.","evidence":"Well-established"},{"condition":"Acute bronchitis with allergic component","description":"Used to reduce cough severity and improve mucus clearance in patients with acute bronchitis who also have allergies.","evidence":"Moderate"},{"condition":"Allergic rhinitis with postnasal drip","description":"Levocetirizine controls allergy symptoms, while Ambroxol thins postnasal drip, providing relief from cough and throat irritation.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chronic sinusitis with thick secretions","description":"Sometimes prescribed to help thin sinus secretions and reduce allergic inflammation, but not a standard approved use.","evidence":"Limited"}]

Primary treatment for: Productive cough with allergic rhinitis

Also treats: Acute bronchitis, Allergic rhinitis, Postnasal drip syndrome

📋 Drug Information

Generic Name(s)Ambroxol + Levocetirizine
Brand NameAlerfix Total Tablet SR
ManufacturerTrident Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic + Antihistamine
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce the chance of stomach upset.
2
Avoid driving or operating heavy machinery until you know how this medicine affects your alertness.
3
Do not consume alcohol while taking this medicine as it can increase drowsiness.
4
If your cough persists for more than 7 days or is accompanied by fever, consult your doctor.
5
Stay well hydrated to help thin mucus and make coughing more productive.
6
Do not use this medicine for dry cough or for cough due to asthma without medical advice.
7
Inform your doctor if you have kidney or liver problems, as dose adjustment may be needed.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Productive cough with mucus
This medicine is commonly prescribed for this.
Likely Use
Runny nose and sneezing
Levocetirizine component helps with allergic symptoms.
Likely Use
Dry cough
This medicine is not for dry cough; it is for productive cough.
Not Primary
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLevocetirizine is rapidly and extensively absorbed after oral administration. Ambroxol is also well absorbed from the gastrointestinal tract. Food does not significantly affect the absorption of either component.
DistributionLevocetirizine distributes widely into body tissues, including the skin and respiratory mucosa. Ambroxol crosses the blood-brain barrier and placenta, and is distributed to lung tissue, where it exerts its mucolytic effects.
Protein BindingLevocetirizine is approximately 90% bound to plasma proteins. Ambroxol is about 80-90% bound to plasma proteins.
MetabolismLevocetirizine undergoes minimal hepatic metabolism. Ambroxol is metabolized in the liver by cytochrome P450 enzymes, primarily CYP3A4, to inactive metabolites.
Half-LifeThe elimination half-life of Levocetirizine is approximately 6-8 hours in adults with normal kidney function. Ambroxol's half-life is about 7-12 hours.
ExcretionLevocetirizine is primarily excreted unchanged in the urine. Ambroxol metabolites are excreted mainly in the urine and to a lesser extent in feces.
BioavailabilityLevocetirizine has a high oral bioavailability of about 90%. Ambroxol's bioavailability is approximately 70-80% due to first-pass metabolism.
Onset of ActionLevocetirizine begins to relieve allergic symptoms within 1 hour. Ambroxol's mucolytic effect starts within 30-60 minutes but full benefit may take a few days.
Peak Plasma TimeLevocetirizine reaches peak plasma concentration in about 0.5-1 hour. Ambroxol peaks at around 1-3 hours after oral intake.
Duration of ActionLevocetirizine's antihistaminic effect lasts about 24 hours, allowing once-daily dosing. Ambroxol's mucolytic effect lasts approximately 6-8 hours, often requiring twice-daily dosing.

How It Works

This medicine combines two active ingredients with complementary actions. Ambroxol is a mucolytic that increases serous bronchial secretion, reduces mucus viscosity, and promotes ciliary clearance, making cough more productive. Levocetirizine is a selective histamine H1-receptor antagonist that blocks histamine released from mast cells, reducing allergic symptoms such as sneezing, itching, and rhinorrhea. Together, they address both the allergic trigger and the mucus component of cough.

Mechanism Steps

1
Histamine blockade: Levocetirizine binds to H1 receptors on blood vessels and nerve endings, preventing histamine from causing sneezing, itching, and runny nose.
2
Mucus thinning: Ambroxol increases the production of serous fluid in the airways and breaks down acidic mucopolysaccharides, reducing mucus thickness.
3
Ciliary clearance: Ambroxol stimulates cilia to beat more effectively, helping move thinned mucus upward for expulsion.
4
Reduced cough reflex: By reducing postnasal drip and allergic irritation, the combination lessens the cough reflex triggered by throat irritation.

💡 How to Take cetril d tablet

Strength: Tablet containing Ambroxol 50 mg and Levocetirizine 5 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with or without food, but taking with food may reduce stomach upset.
4Take at the same time each day to maintain consistent levels.
5Do not exceed the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, as prescribed by your doctor. The exact dose and duration depend on the condition being treated, your age, kidney and liver function, and response to therapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the sedative effects of levocetirizine. Dose adjustment may be required based on renal function. Consult your doctor for appropriate dosing.
Renal ImpairmentIn patients with renal impairment, dose reduction of levocetirizine is recommended. For moderate renal impairment, the dose may be reduced to one tablet once daily. In severe renal impairment, use is not recommended unless advised by a doctor. Ambroxol may also require dose adjustment. Consult your nephrologist.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. In severe hepatic impairment, use with caution and monitor liver function. Consult your doctor for appropriate dosing.
Maximum Daily DoseThe maximum recommended daily dose is one tablet twice daily, but this must be confirmed by your doctor. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cetril d tablet

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you. Usually resolves with continued use.
Dry mouth (Common (5-10%))
Sip water frequently or chew sugar-free gum. Consult doctor if persistent.
Fatigue (Common (5-10%))
Get adequate rest. If fatigue interferes with daily activities, consult your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Nausea (Uncommon (1-5%))
Take with food to reduce stomach upset. Consult doctor if vomiting occurs.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, swelling of face or throat, or difficulty breathing.
Palpitations or irregular heartbeat (Rare (<0.1%))
Contact your doctor immediately if you notice a fast or irregular heartbeat.
Urinary retention (Rare (<0.1%))
Consult a doctor if you have difficulty passing urine.

⚠️ Rare Side Effects

Tremors
Report to your doctor if you experience shaking or tremors.
Jaundice
Seek medical attention if you notice yellowing of skin or eyes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CNS depressants Major
Alcohol Major
Ritonavir Moderate
Theophylline Moderate
Anticholinergics Minor

🚨 Major Interactions

  • CNS depressants (e.g., benzodiazepines, opioids)
  • Alcohol

⚡ Moderate Interactions

  • Ritonavir
  • Theophylline

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can enhance the sedative effects of levocetirizine and impair your ability to drive or operate machinery. Combining alcohol with this medicine may also increase the risk of dizziness, drowsiness, and difficulty concentrating.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Ambroxol, Levocetirizine, or any component of the formulation","Severe renal impairment (creatinine clearance < 10 mL/min) without dose adjustment","Children under 12 years of age (safety and efficacy not established)","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding without medical advice"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption while taking this medicine.","Use with caution in patients with kidney or liver disease; dose adjustment may be needed.","Do not use for dry cough or for cough lasting more than 7 days without medical advice.","May increase the risk of urinary retention in patients with prostate enlargement.","Not recommended for children under 12 years.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Levocetirizine passes into breast milk in small amounts and may cause drowsiness in the infant. Ambroxol is also excreted in breast milk. This medicine is not recommended during breastfeeding unless advised by a doctor. If prescribed, monitor the baby for excessive sleepiness.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, dizziness, nausea, and in extreme cases, respiratory depression. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Do not consume alcohol while taking this medicine, as it can increase drowsiness and impair your ability to perform tasks. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you have kidney or liver problems, your doctor may need to adjust your dose. Do not use this medicine for a dry cough or for cough lasting more than 7 days without consulting a doctor. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the sedative and anticholinergic effects of this medicine. Dose adjustment may be needed based on kidney function. Monitor for confusion, dizziness, and urinary retention.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Levocetirizine and Ambroxol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

🏥 Post-Surgery Considerations

This medicine may cause drowsiness and dry mouth, which can affect recovery after surgery. Inform your surgeon and anesthesiologist about all medicines you are taking. It is generally advisable to avoid this medicine before surgery unless prescribed.

🦷 Dental Procedures

This medicine may cause dry mouth, which can increase the risk of dental problems. Inform your dentist if you are taking this medicine. Maintain good oral hygiene and stay hydrated.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus and ease coughing.
🥗
Use a humidifier at home to keep airways moist.
😴
Avoid exposure to allergens such as dust, pollen, and pet dander.
💧
Get plenty of rest to support your immune system.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid smoking and secondhand smoke.

🏋️ Exercise Considerations

This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Light exercise like walking may be fine if you feel up to it.

🥗 Diet Recommendations

Drink warm fluids like herbal tea or soup to soothe the throat.
Include foods rich in vitamin C to support immunity.
Avoid cold drinks and ice cream as they may worsen cough.
Eat a balanced diet with plenty of fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged use of levocetirizine may lead to tolerance or increased sedation. Ambroxol is generally well tolerated, but rare liver enzyme elevations have been reported. Regular monitoring of kidney and liver function may be advised. Do not continue for more than 7 days without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and relieve congestion naturally.

Evidence: Well-established
Saline nasal irrigation

Can reduce postnasal drip and allergy symptoms.

Evidence: Moderate
Allergen avoidance

Reducing exposure to allergens can decrease the need for medication.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies and productive cough
She was prescribed this medicine for her cough and runny nose. After taking it for 3 days, she noticed significant relief in her cough and sneezing. She experienced mild drowsiness initially, which subsided after a few days. She was advised to take it with food to avoid stomach upset.
💡 Lesson: Taking this medicine with food and avoiding driving until you know its effects can improve tolerability and safety.
👤 A 50-year-old man with chronic bronchitis and allergic rhinitis
He started this medicine as prescribed. His cough became more productive, and his nasal symptoms improved. He was advised to drink plenty of water and avoid alcohol. He reported no serious side effects.
💡 Lesson: Staying hydrated and following doctor's advice enhances the effectiveness of this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Levocetirizine starts relieving allergy symptoms within 1 hour, while Ambroxol's mucolytic effect may take a few hours to days for full benefit.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.

Q: Is it safe to drive after taking this medicine?

A: This medicine may cause drowsiness. Avoid driving or operating machinery until you know how it affects you.

Q: Can I take this medicine if I am pregnant?

A: Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant. It should be used only if clearly needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for cetril d tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is an antibiotic.
    Fact: This medicine is not an antibiotic. It is a combination of a mucolytic and an antihistamine.
  • Myth: It can cure any type of cough.
    Fact: It is effective only for productive cough with allergic components. It is not for dry cough or infections requiring antibiotics.
  • Myth: It is safe to take long-term without doctor's advice.
    Fact: Long-term use should be monitored by a doctor due to potential side effects and the need to address the underlying cause.

🔄 Alternative Options

Generic Alternatives

  • Ambroxol + Levocetirizine combination generics available

Brand Alternatives

  • Cetril-D
  • Ambrodil-L
  • Levocet-M
  • Mucolite-L

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","ingredients":"Ambroxol 50 mg + Levocetirizine 5 mg","primary_use":"Productive cough with allergy","sedation":"Moderate"},{"medicine":"Ambroxol + Cetirizine","ingredients":"Ambroxol 50 mg + Cetirizine 10 mg","primary_use":"Productive cough with allergy","sedation":"Higher"},{"medicine":"Levocetirizine alone","ingredients":"Levocetirizine 5 mg","primary_use":"Allergic rhinitis","sedation":"Low"}]

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