centradol 100mg injection - Tramadol (100mg) medicine

centradol 100mg injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Tablets India Limited ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is centradol 100mg injection used for?

Asic 50mg Tablet (Tramadol) is used to treat PAIN ANALGESICS. It contains Tramadol (100mg), which Binds to mu-opioid receptors and inhibits serotonin and norepinephrine reuptake.. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Tramadol
  • Manufacturer: Tablets India Limited
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š centradol 100mg injection Uses & Benefits

Moderate to moderately severe pain.

Off-label uses: Restless legs syndrome, premature ejaculation, neuropathic pain.

๐Ÿ“‹ Drug Information

Generic Name(s)Tramadol
Brand NameAsic 50mg Tablet
ManufacturerTablets India Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassOpioids
Route of AdministrationOral.
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly and almost completely absorbed after oral administration.
DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.
Protein BindingApproximately 20% bound to plasma proteins.
MetabolismExtensively metabolized in the liver via CYP2D6 and CYP3A4 to active metabolite O-desmethyltramadol (M1).
Half-LifeApproximately 5-6 hours for tramadol; 7-9 hours for M1.
ExcretionPrimarily renal (90%), with about 30% excreted as unchanged drug.
BioavailabilityApproximately 70-75% after oral administration.
Onset of ActionWithin 1 hour.
Peak Plasma Time2 hours.
Duration of Action4-6 hours.

How It Works

Binds to mu-opioid receptors and inhibits serotonin and norepinephrine reuptake.

Mechanism Steps

1Binds to mu-opioid receptors in the CNS, activating G-protein coupled receptors.
2Inhibits adenylate cyclase, reducing cAMP levels.
3Opens potassium channels and closes calcium channels, reducing neurotransmitter release.

๐Ÿ’ก How to Take centradol 100mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of centradol 100mg injection

โœ… Common Side Effects

  • Nausea
  • Dizziness
  • Drowsiness
  • Constipation
  • Headache
  • Vomiting
  • Sweating
  • Dry mouth

๐Ÿšจ Serious Side Effects

  • Seizures
  • Serotonin syndrome
  • Respiratory depression
  • Hypotension
  • Bradycardia
  • QT prolongation
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Adrenal insufficiency
  • SIADH
  • Hepatotoxicity
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Risk of serotonin syndrome
SSRIs Major Increased risk of serotonin syndrome
SNRIs Major Increased risk of serotonin syndrome
TCAs Major Increased risk of seizures and serotonin syndrome
Linezolid Major Risk of serotonin syndrome
Methylene Blue Major Risk of serotonin syndrome
Other CNS depressants Major Additive CNS depression
Alcohol Major Increased CNS depression and seizure risk
Carbamazepine Moderate Reduced tramadol efficacy
Rifampin Moderate Reduced tramadol efficacy
Quinidine Moderate Increased tramadol levels
CYP2D6 inhibitors Moderate Altered tramadol metabolism
CYP3A4 inhibitors Moderate Increased tramadol levels
Digoxin Minor Possible increased digoxin levels
Warfarin Minor Possible increased INR

๐Ÿšจ Major Interactions

  • MAOIs
  • SSRIs
  • SNRIs
  • TCAs
  • Linezolid
  • Methylene Blue
  • Other CNS depressants
  • Alcohol

โšก Moderate Interactions

  • Carbamazepine
  • Rifampin
  • Quinidine
  • CYP2D6 inhibitors
  • CYP3A4 inhibitors

โ„น๏ธ Minor Interactions

  • Digoxin
  • Warfarin

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase levels

๐Ÿท Alcohol Interaction

Increased CNS depression and risk of seizures.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, acute intoxication with alcohol or CNS depressants, severe respiratory depression, MAOI use within 14 days, uncontrolled seizures.

๐Ÿ“Š Monitoring Parameters

Pain relief, respiratory rate, blood pressure, heart rate, signs of serotonin syndrome, seizure activity.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; naloxone may reverse respiratory depression but not all effects; monitor for seizures.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for centradol 100mg injection

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Alternative brands with exact same active ingredient (Tramadol (100mg)):

Medical Note: Always consult your doctor before switching medications.

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