Acitrom 1 Tablet (acenocoumarol 1 Mg): Complete Patient Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool, black tarry stools, or vomiting blood
- Red or brown urine
- Severe headache, confusion, weakness on one side, or difficulty speaking
- Coughing up blood or sudden shortness of breath
- Heavy or uncontrollable bleeding from any site
- Sudden severe abdominal or back pain
- Painful dark or blistering skin patches, especially in the first few days
- Blue or purple discoloration and pain in the toes
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Any head injury, even if you feel well
If experiencing severe symptoms, call emergency services immediately.
What is cenorol 1mg tablet used for?
This medicine contains acenocoumarol 1 mg, an oral anticoagulant that helps prevent and treat harmful blood clots. It is used for deep vein thrombosis, pulmonary embolism, atrial fibrillation, and mechanical heart valves. It requires regular INR blood tests and must be taken exactly as prescribed.
- Generic Name: Acenocoumarol
- Manufacturer: East West Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cenorol 1mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसेनोकौमारोल 1 मिलीग्राम की गोली है, जिसे खून को पतला करने वाली दवा कहा जाता है। यह शरीर में खून के थक्के बनने से रोकती है और पहले से बने थक्कों को बढ़ने से रोकती है। डॉक्टर इसे पैरों की गहरी नसों में थक्का, फेफड़ों में थक्का, दिल की अनियमित धड़कन यानी एट्रियल फिब्रिलेशन, और कृत्रिम हृदय वाल्व वाले मरीजों में स्ट्रोक या थक्के से बचाव के लिए लिखते हैं। यह दवा तभी सुरक्षित है जब आप नियमित रूप से आईएनआर जांच कराते रहें और डॉक्टर के बताए अनुसार ही डोज लें। इस दवा को अपने मन से शुरू या बंद न करें।
साइड इफेक्ट्स: इस दवा का सबसे आम साइड इफेक्ट खून बहना है, जैसे आसानी से चोट लगने पर नील पड़ना, नाक से खून आना, मसूड़ों से खून आना, या छोटी चोट से ज्यादा देर तक खून बहना। कुछ लोगों को जी मिचलाना, पेट में हल्की तकलीफ, दस्त, या त्वचा पर दाने हो सकते हैं। कभी-कभी बाल झड़ना, त्वचा का काला पड़ना, या पैर की उंगलियों का नीला-बैंगनी होना भी हो सकता है। गंभीर खून बहना जैसे पेशाब या मल में खून आना, उल्टी में खून आना, या दिमाग में खून बहना दुर्लभ है, लेकिन आपातकालीन इलाज की जरूरत होती है। नियमित आईएनआर जांच से यह जोखिम कम रहता है।
सुरक्षा सलाह: इस दवा को रोज एक ही समय पर लें, आमतौर पर शाम को, ताकि आईएनआर जांच के नतीजे सही आएं। अपनी डोज खुद से कभी न बदलें, क्योंकि डोज सिर्फ डॉक्टर आईएनआर रिपोर्ट देखकर तय करते हैं। खून की जांच के सभी अपॉइंटमेंट समय पर कराएं, खासकर शुरुआत के हफ्तों में और डोज बदलने के बाद। किसी भी डॉक्टर, दंत चिकित्सक, या फार्मासिस्ट को बताएं कि आप यह दवा ले रहे हैं। शराब से बचें, क्योंकि इससे खून बहने का खतरा बढ़ सकता है। नरम टूथब्रश और इलेक्ट्रिक रेजर का इस्तेमाल करें। अपने साथ मेडिकल अलर्ट कार्ड रखें। बिना डॉक्टर से पूछे कोई भी नई दवा, दर्द निवारक, या हर्बल प्रोडक्ट न लें।
💊 cenorol 1mg tablet Uses & Benefits
[{"condition":"Deep vein thrombosis (DVT)","description":"Used to treat existing blood clots in the deep veins of the legs and to prevent new clots from forming.","evidence":"Well-established"},{"condition":"Pulmonary embolism (PE)","description":"Prescribed to treat clots that have traveled to the lungs and to prevent recurrence.","evidence":"Well-established"},{"condition":"Atrial fibrillation","description":"Helps reduce the risk of stroke in people with irregular heart rhythm when anticoagulation is needed.","evidence":"Well-established"},{"condition":"Mechanical heart valves","description":"Used long-term to prevent clot formation on artificial heart valves.","evidence":"Well-established"},{"condition":"Post-operative clot prevention","description":"Sometimes used after major orthopedic or cardiac surgery when the risk of clot formation is high.","evidence":"Established"}]
Off-label uses: [{"condition":"Antiphospholipid syndrome","description":"May be used in some patients with this clotting disorder when other anticoagulants are not suitable.","evidence":"Limited"},{"condition":"Cerebral venous sinus thrombosis","description":"Occasionally prescribed for clots in the brain's venous sinuses under specialist care.","evidence":"Limited"}]
Primary treatment for: Thromboembolic disorders requiring anticoagulation
Also treats: Atrial fibrillation, Deep vein thrombosis, Pulmonary embolism, Mechanical heart valve replacement, Antiphospholipid syndrome
📋 Drug Information
| Generic Name(s) | Acenocoumarol |
| Brand Name | Acitrom 2 Tablet |
| Manufacturer | East West Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Vitamin K antagonists |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place. Keep the tablets in their original container, tightly closed, away from direct sunlight and moisture. Do not store in the bathroom. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine blocks the enzyme vitamin K epoxide reductase, which is needed to recycle vitamin K in the liver. Without enough active vitamin K, the liver cannot properly make clotting factors II, VII, IX, and X, as well as proteins C and S. As a result, the blood takes longer to clot. This effect is not immediate because the clotting factors already present in the blood must first wear off.
Mechanism Steps
💡 How to Take cenorol 1mg tablet
Strength: Acenocoumarol 1 mg immediate-release oral tablet
Dosage Information
| Adult Dosage | The starting dose of this medicine is usually 1 mg to 2 mg once daily, but the exact dose is individualized by a qualified clinician based on the indication, INR response, age, weight, liver function, kidney function, and other medicines being taken. After starting, the dose is adjusted according to regular INR checks, which are often done every few days at first and then every 1 to 4 weeks once stable. Some people need as little as 0.5 mg daily, while others need 4 mg or more. Never change the dose on your own. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults are more sensitive to the effects of this medicine and have a higher risk of bleeding. They often need lower doses and more frequent INR monitoring. Falls, poor appetite, and multiple medicines can increase risk. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Kidney disease can increase the effect of this medicine and the risk of bleeding. People with reduced kidney function usually need lower doses and closer INR monitoring. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Liver disease reduces the production of clotting factors and changes how this medicine is metabolized. People with liver disease are more sensitive to its effects and may need lower doses with careful monitoring. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the INR response. Doses above 10 mg per day are rarely needed. The dose is adjusted only by a qualified clinician based on INR results. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cenorol 1mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Fluconazole | Major | |
| Erythromycin | Major | |
| Amiodarone | Major | |
| Rifampicin | Major | |
| Carbamazepine | Major | |
| Paracetamol (high dose) | Moderate | |
| Vitamin K supplements | Moderate |
🚨 Major Interactions
- Other anticoagulants (e.g., warfarin, heparin, direct oral anticoagulants)
- NSAIDs (e.g., aspirin, ibuprofen, diclofenac)
- Antiplatelet drugs (e.g., clopidogrel, ticagrelor)
- Azole antifungals (e.g., fluconazole, ketoconazole)
- Macrolide antibiotics (e.g., erythromycin, clarithromycin)
- Amiodarone
- Rifampicin
- Carbamazepine and phenytoin
⚡ Moderate Interactions
- Paracetamol (high doses)
- Statins (e.g., simvastatin, atorvastatin)
- Levothyroxine
- Tramadol
- Corticosteroids
🍷 Alcohol Interaction
Alcohol can interact dangerously with this medicine. Occasional small amounts may not cause problems for some people, but binge drinking or daily heavy drinking can raise INR and cause serious bleeding. Alcohol can also damage the liver, which changes how this medicine is metabolized. The safest approach is to avoid alcohol or discuss a safe limit with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active bleeding or high risk of bleeding","Severe liver disease or severe kidney disease","Uncontrolled severe high blood pressure","Recent major surgery or trauma with bleeding risk","Pregnancy, especially the first and third trimesters","Known allergy or hypersensitivity to acenocoumarol","Severe thrombocytopenia or bleeding disorders","Inability to attend regular INR monitoring"]
⚠️ Warnings & Precautions
["This medicine has a narrow safety margin. Small changes in dose, diet, or other medicines can cause serious bleeding or loss of effect.","Never start or stop any medicine, including over-the-counter pain relievers, without telling your doctor.","Keep vitamin K intake steady. Do not suddenly eat large amounts of leafy green vegetables.","Tell your doctor if you plan to travel, as INR monitoring may need to be arranged at your destination.","Avoid contact sports and activities with a high risk of injury.","Use a soft toothbrush and an electric razor to reduce bleeding from minor injuries.","Carry a medical alert card or wear a bracelet stating that you take an anticoagulant.","Seek medical help immediately after any head injury, even if you feel fine, because bleeding in the brain can be delayed."]
🤱 Lactation Safety
This medicine passes into breast milk in very small amounts. It is generally considered compatible with breastfeeding, but the baby should be monitored for unusual bruising or bleeding. Discuss with your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
An overdose of this medicine can cause serious or life-threatening bleeding. If you suspect an overdose, seek emergency medical care immediately. Treatment may include stopping the medicine, giving vitamin K by mouth or injection, and in severe cases, giving fresh frozen plasma or prothrombin complex concentrate. Do not try to treat an overdose at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember on the same day. If you do not remember until the next day, skip the missed dose and take your next dose at the usual time. Never take two doses on the same day to make up for a missed dose. If you are unsure what to do, contact your doctor or anticoagulation clinic.
Additional Safety Advice
Take this medicine exactly at the same time each day, usually in the evening, so that your INR test results are consistent. Never change your dose on your own, even if you feel well, because the dose is adjusted only by your doctor based on INR reports. Keep all blood test appointments, especially in the first few weeks and after any dose change. Tell every doctor, dentist, or pharmacist that you take this medicine before any procedure or new prescription. Avoid alcohol, as it can change how this medicine works and increase bleeding risk. Use a soft toothbrush and an electric razor to reduce bleeding from small injuries. Wear a medical alert card or bracelet stating that you take an anticoagulant. Do not take aspirin, ibuprofen, or other pain relievers without checking with your doctor first. If you miss a dose, follow your doctor's specific instructions and never double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to this medicine and have a higher risk of bleeding, especially if they have falls, poor appetite, or multiple medicines. They often need lower doses and more frequent INR checks. Review all medicines regularly with the doctor to avoid interactions. Use walking aids if needed to prevent falls, and report any bruising or bleeding promptly.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy because it can cause bleeding in the baby and birth defects. If you are planning pregnancy, talk to your doctor before you conceive. You will need to switch to a safer anticoagulant, usually a low molecular weight heparin, before becoming pregnant. Use effective contraception while taking this medicine unless your doctor advises otherwise.
🏥 Post-Surgery Considerations
Tell your surgeon and anesthesiologist that you take this medicine before any surgery. You may need to stop it several days before the procedure and use a different anticoagulant in the meantime. After surgery, your doctor will decide when it is safe to restart and will monitor your INR closely. Do not restart on your own.
🦷 Dental Procedures
Tell your dentist that you take this medicine before any dental work, including cleanings, fillings, and extractions. Your dentist may check your INR or ask you to get it tested before the procedure. For minor procedures, treatment may continue with extra care to control bleeding. For major dental surgery, your doctor may adjust the dose temporarily. Never stop the medicine on your own before a dental visit.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is good for your heart and circulation, but avoid contact sports, heavy lifting, and activities with a high risk of falls or injury. Walking, swimming, and cycling on a stationary bike are usually safe. If you injure yourself, apply pressure to stop bleeding and seek medical help if bleeding does not stop or if you hit your head.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their usual work and daily activities while taking this medicine. Office work and light activity are generally safe. Jobs that involve a high risk of injury, such as construction, firefighting, or professional sports, may need review with your doctor. You can usually drive, but avoid driving if you feel dizzy or unwell. Always carry your medical alert card and inform your employer about your medicine if your job has injury risks.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Stopping suddenly can cause a dangerous blood clot. Your doctor will decide when it is safe to stop based on your condition, INR results, and whether you need long-term anticoagulation. If you develop serious bleeding or a severe allergic reaction, seek emergency care immediately and follow medical advice about stopping.
📅 Long-Term Use Effects
Long-term use of this medicine is safe when INR is monitored regularly and kept in the target range. The main risk is bleeding, which can occur at any time but is more likely if INR is too high. Rarely, long-term use can cause hair loss, skin changes, or liver enzyme elevation. Regular blood tests, dose reviews, and a steady diet help reduce these risks. Your doctor will review whether you still need this medicine and whether a newer anticoagulant might suit you better.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as rivaroxaban, apixaban, or dabigatran may be suitable alternatives for some people and do not need routine INR monitoring.
Evidence: Well-establishedCan help prevent deep vein thrombosis in people at risk, especially during travel or after surgery.
Evidence: Well-establishedRegular exercise, weight management, and a heart-healthy diet can reduce the risk of clots and support overall health.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and most vaccines. However, injections can cause bruising or bleeding at the injection site. Tell the person giving the vaccine that you take an anticoagulant, and apply pressure to the site for a few minutes after the injection. If you have a bleeding disorder or very high INR, your doctor may advise delaying vaccination until your INR is stable.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless the label says so
✅ DO
Keep the tablets in their original container, tightly closed
❌ DON'T
Do not transfer them to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription copy and a medical alert card. Pack enough tablets for the entire trip plus a few extra days in case of delays. If you cross time zones, ask your doctor how to adjust the timing of your dose so that you do not take two doses too close together. Store the tablets at room temperature and away from direct sunlight and moisture. Arrange for INR monitoring at your destination if your trip is longer than a few weeks. Declare the medicine at customs if required and keep it in your hand luggage, not in checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anticoagulant effect begins within 24 to 36 hours, but the full effect usually takes 3 to 5 days. Your doctor will check your INR to confirm that the dose is right.
A: The target INR range depends on why you are taking this medicine. For many conditions it is 2.0 to 3.0, but for mechanical heart valves it may be 2.5 to 3.5. Your doctor will tell you your target range.
A: Occasional paracetamol is usually safe, but regular high doses can raise INR. Tell your doctor if you need it often.
A: No. These medicines increase bleeding risk and should be avoided unless your doctor specifically prescribes them with stomach protection.
A: If you remember on the same day, take it as soon as you remember. If you remember the next day, skip the missed dose and take your next dose at the usual time. Never double the dose.
A: It is best to avoid alcohol. Binge drinking or daily heavy drinking can raise INR and cause serious bleeding.
A: No. This medicine is contraindicated in pregnancy because it can harm the baby. Use effective contraception and talk to your doctor about safer alternatives.
A: The duration depends on your condition. Some people take it for a few months, while others need it lifelong. Your doctor will review your need regularly.
🤔 Common Patient Concerns
🔄 Substitutes for cenorol 1mg tablet
View AllAlternative brands with exact same active ingredient:
-
nicoz 1mg tabletAjanta Pharma Ltd ₹26.92 7.7% CHEAPER
-
nistrom 1mg tabletNeiss Labs Pvt Ltd ₹27.50 5.7% CHEAPER
-
acethromb 1mg tabletSuvik Hitek Pvt Ltd ₹31.20 7% COSTLIER
-
nicofax 1mg tabletChemo Healthcare Pvt Ltd ₹53.44 83.3% COSTLIER
-
aceno 1mg tabletZydus Cadila ₹55.00 88.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine dissolves existing blood clots.
Fact: This medicine does not dissolve clots. It prevents new clots from forming and stops existing clots from getting bigger. Other medicines are used to dissolve clots. - Myth: Once my INR is normal, I can stop the medicine.
Fact: A normal INR only means the dose is right for now. Stopping suddenly can cause a dangerous clot. Always follow your doctor's advice. - Myth: I can eat as many leafy green vegetables as I want.
Fact: Leafy greens are healthy, but sudden large changes in vitamin K intake can change your INR. Keep your intake steady. - Myth: This medicine is safe to take with any painkiller.
Fact: Many painkillers, especially NSAIDs like ibuprofen and aspirin, increase bleeding risk. Always check with your doctor first. - Myth: If I feel fine, I do not need blood tests.
Fact: You can feel fine even when your INR is too high or too low. Regular blood tests are essential for safety.
🔄 Alternative Options
Generic Alternatives
- Acenocoumarol 1 mg tablet
Brand Alternatives
- Acitrom 1 tablet