celavi-trio tablet - Uses, Price, Side Effects & Substitutes
What is celavi-trio tablet used for?
Cilidin Trio 20mg/10mg/12.5mg Tablet (Olmesartan Medoxomil + Cilnidipine) is used to treat CARDIAC. It contains Olmesartan Medoxomil (20mg) + Cilnidipine (10mg), which Olmesartan blocks angiotensin II AT1 receptors; Cilnidipine blocks L-type and N-. Always consult your doctor before use. Take as prescribed.
- Generic Name: Olmesartan Medoxomil + Cilnidipine
- Manufacturer: Ajanta Pharma Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ celavi-trio tablet Uses & Benefits
Off-label uses: Diabetic nephropathy, Chronic kidney disease
๐ Drug Information
| Generic Name(s) | Olmesartan Medoxomil + Cilnidipine |
| Brand Name | Cilidin Trio 20mg/10mg/12.5mg Tablet |
| Manufacturer | Ajanta Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin II Receptor Blocker (ARB) + Calcium Channel Blocker (CCB) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Olmesartan blocks angiotensin II AT1 receptors; Cilnidipine blocks L-type and N-type calcium channels
Mechanism Steps
๐ก How to Take celavi-trio tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of celavi-trio tablet
โ Common Side Effects
- Dizziness
- Headache
- Peripheral edema
- Fatigue
- Cough
๐จ Serious Side Effects
- Angioedema
- Hyperkalemia
- Acute renal failure
- Hypotension
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Rhabdomyolysis
- Stevens-Johnson syndrome
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | Increased lithium toxicity risk |
| NSAIDs | Major | Reduced antihypertensive effect, increased renal impairment risk |
| Potassium-sparing diuretics | Major | Hyperkalemia risk |
| CYP3A4 inhibitors | Major | Increased cilnidipine levels |
| Antidiabetic agents | Moderate | Enhanced hypoglycemic effect |
| Beta-blockers | Moderate | Additive bradycardia |
| Digoxin | Moderate | Increased digoxin levels |
| Antacids | Minor | Reduced absorption |
| Cimetidine | Minor | Increased cilnidipine levels |
๐จ Major Interactions
- Lithium
- NSAIDs
- Potassium-sparing diuretics
- CYP3A4 inhibitors (e.g., ketoconazole)
โก Moderate Interactions
- Antidiabetic agents
- Beta-blockers
- Digoxin
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice (increases cilnidipine levels); high-fat meal reduces absorption
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, bilateral renal artery stenosis, severe hepatic impairment, hypotension
๐ Monitoring Parameters
Blood pressure, serum potassium, renal function, liver function
๐คฑ Lactation Safety
Not recommended; excreted in milk in animal studies
๐ Overdose Management
Symptomatic treatment; monitor BP, ECG; gastric lavage if recent
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double