Adpime 1000mg Injection (Cefepime): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat.
- A painful, spreading rash with blisters or peeling skin.
- Watery or bloody diarrhea with stomach cramps or fever.
- Confusion, drowsiness, muscle twitching, or seizures.
- Decreased urine output or swelling in the legs and feet.
- Unusual bruising or bleeding.
- Yellowing of the skin or eyes.
- Severe pain, redness, or swelling at the injection site.
If experiencing severe symptoms, call emergency services immediately.
What is cefoxitin 1000mg injection used for?
This medicine is an intravenous fourth-generation cephalosporin antibiotic containing Cefepime 1000mg. It is used in hospitals to treat serious bacterial infections such as pneumonia, complicated urinary tract infections, skin infections, and febrile neutropenia. It works by breaking down the bacterial cell wall, leading to bacterial death. It must be given by a healthcare professional and is not effective against viral infections.
- Generic Name: Cefepime
- Manufacturer: Capsutab Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefoxitin 1000mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफेपाइम 1000 मिलीग्राम इंजेक्शन है, जो एक चौथी पीढ़ी का सेफलोस्पोरिन एंटीबायोटिक है। इसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे निमोनिया, मूत्र मार्ग का संक्रमण, त्वचा का संक्रमण, पेट के अंदर का संक्रमण, और कैंसर रोगियों में बुखार के साथ कम सफेद रक्त कोशिकाएं। यह दवा नस के माध्यम से दी जाती है और इसे डॉक्टर या नर्स ही लगाते हैं। यह वायरल संक्रमण जैसे सर्दी-जुकाम या फ्लू के लिए काम नहीं करती। इसका सेवन डॉक्टर की सलाह के बिना न करें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, त्वचा पर चकत्ते, खुजली, सिरदर्द, और इंजेक्शन लगाने की जगह पर दर्द या लालिमा शामिल हैं। कुछ रोगियों में गंभीर एलर्जी, त्वचा की गंभीर प्रतिक्रिया, दस्त जो खून के साथ हो, दौरे, और गुर्दे की समस्या हो सकती है। अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, या त्वचा पर फफोले दिखें तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। अगर आपको पेनिसिलिन या सेफलोस्पोरिन से एलर्जी है तो पहले ही डॉक्टर को बताएं। इलाज के दौरान गुर्दे की कार्यप्रणाली की जांच होती रहनी चाहिए। दवा का कोर्स पूरा करें, बीच में न छोड़ें। शराब न पिएं। दस्त, चकत्ते, सांस लेने में तकलीफ, या पेशाब कम आने पर तुरंत डॉक्टर से संपर्क करें।
💊 cefoxitin 1000mg injection Uses & Benefits
[{"condition":"Hospital-acquired pneumonia","description":"Used to treat pneumonia that develops during or after a hospital stay, including ventilator-associated pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against many gram-negative bacteria that cause kidney and bladder infections, including some resistant strains.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Prescribed for serious skin infections such as cellulitis, abscesses, and surgical wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections such as peritonitis and intra-abdominal abscess.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Commonly used as empiric therapy in cancer patients with fever and low white blood cell counts.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Used to treat bacteremia caused by susceptible gram-negative and gram-positive bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Sometimes used for osteomyelitis and septic arthritis when the causative organism is susceptible.","evidence":"Moderate"},{"condition":"Meningitis","description":"Used in some cases of bacterial meningitis caused by susceptible organisms, often in combination with other antibiotics.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Occasionally used before some surgeries in patients with beta-lactam allergies or specific risk factors, though this is not a standard first-choice prophylaxis.","evidence":"Limited"},{"condition":"Febrile neutropenia in outpatient settings","description":"Sometimes used in outpatient parenteral antibiotic therapy programs for selected stable patients.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections caused by susceptible organisms, including hospital-acquired pneumonia, complicated urinary tract infections, and febrile neutropenia.
Also treats: Skin and soft tissue infections, Intra-abdominal infections, Bloodstream infections, Bone and joint infections, Meningitis caused by susceptible bacteria
📋 Drug Information
| Generic Name(s) | Cefepime |
| Brand Name | Appime 250mg Injection |
| Manufacturer | Capsutab Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 4th generation |
| Route of Administration | Intravenous (into a vein) after reconstitution and appropriate dilution. It is given as a slow infusion over about 30 minutes, or as directed by the clinician |
| Storage | Store the unopened vial at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted, the solution should be used within the time specified by the manufacturer or stored as directed by the pharmacy. Do not freeze the reconstituted solution unless the label specifically allows it. |
| Shelf Life | The shelf life of the unopened vial is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Always check the expiry date on the vial before use. Once reconstituted, use within the recommended time period. |
| WHO Guideline | Not established from the available information. The World Health Organization includes cefepime in some essential medicines lists, but specific guideline recommendations vary by infection and region. Always follow local hospital guidelines and your doctor's advice. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research publishes antibiotic use guidelines that may include cefepime for specific infections. Your doctor will follow the most appropriate local guideline. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a beta-lactam antibiotic that kills bacteria by interfering with the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins located on the inner membrane of the bacterial cell, which prevents the cross-linking of peptidoglycan chains. Without proper cross-linking, the bacterial cell wall becomes weak and the cell bursts under normal osmotic pressure. Because human cells do not have a peptidoglycan cell wall, this medicine is selectively toxic to bacteria. Cefepime is classified as a fourth-generation cephalosporin because it is stable against many beta-lactamases and has good activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.
Mechanism Steps
💡 How to Take cefoxitin 1000mg injection
Strength: This medicine is supplied as a sterile powder for injection containing Cefepime 1000mg per vial. It is reconstituted with a suitable diluent before intravenous infusion.
Dosage Information
| Adult Dosage | The adult dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the causative organism, and the patient's kidney function. Common adult regimens range from 1 gram to 2 grams given intravenously every 8 to 12 hours. For serious infections such as febrile neutropenia or hospital-acquired pneumonia, higher doses or more frequent intervals may be used. In patients with kidney impairment, the dose or dosing interval must be adjusted. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, this medicine may be used in children for serious infections, but the dose is based on weight and kidney function and must be determined by a pediatric specialist. |
| Elderly Dosage | Elderly patients may need a lower dose or longer dosing interval because kidney function often declines with age. Kidney function should be checked before and during treatment. Elderly patients are also at higher risk of neurological side effects such as confusion and seizures, so they should be monitored closely. |
| Renal Impairment | The dose of this medicine must be reduced in patients with kidney impairment. The exact adjustment depends on the measured creatinine clearance or estimated glomerular filtration rate. Your doctor will calculate the appropriate dose and interval. In patients on dialysis, a supplemental dose may be needed after dialysis. Do not adjust the dose without medical advice. |
| Hepatic Impairment | No specific dose adjustment is usually required for patients with liver disease alone, because this medicine is mainly eliminated by the kidneys. However, if liver disease is accompanied by kidney impairment, the dose should be adjusted based on kidney function. Your doctor will decide the appropriate dose. |
| Maximum Daily Dose | The maximum daily dose is not fixed for all patients. In adults with normal kidney function, doses up to 6 grams per day have been used in severe infections under specialist supervision. The exact maximum must be determined by a qualified clinician based on the infection and the patient's condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefoxitin 1000mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Amikacin | Major | |
| Tobramycin | Major | |
| Oral contraceptives | Moderate | |
| Metformin | Minor | |
| Antacids | Minor | |
| Other cephalosporins | Moderate |
🚨 Major Interactions
- Aminoglycosides such as gentamicin, tobramycin, or amikacin
- Loop diuretics such as furosemide
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Other beta-lactam antibiotics
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It can increase the risk of nausea, vomiting, dizziness, and stomach irritation. Alcohol may also worsen dehydration if you have diarrhea or fever. There is no direct chemical interaction that makes alcohol dangerous, but avoiding it supports recovery and reduces strain on the liver and kidneys.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergic reaction to cefepime or any other cephalosporin antibiotic.","Known severe immediate hypersensitivity to penicillin antibiotics, because of the risk of cross-reactivity.","Use of the medicine for infections caused by organisms known to be resistant to cefepime.","Not for use in patients with a history of serious beta-lactam-associated anaphylaxis without specialist evaluation."]
⚠️ Warnings & Precautions
["Before treatment, tell your doctor about all allergies, especially to antibiotics.","Kidney function should be checked before and during treatment because the dose may need adjustment.","Use with caution in elderly patients, who are more prone to kidney injury and neurological side effects.","Prolonged use can lead to overgrowth of non-susceptible organisms, including fungi.","Antibiotic-associated diarrhea can occur during or after treatment. Report severe or bloody diarrhea.","This medicine may cause seizures, especially in patients with kidney impairment. Report confusion or abnormal movements.","Do not use this medicine to treat viral infections such as colds or flu.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Avoid alcohol during treatment.","Keep all follow-up appointments for monitoring and dose adjustment."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is usually considered compatible with breastfeeding, but the baby should be monitored for diarrhea, thrush, or rash. If you are breastfeeding, talk to your doctor before starting this medicine.
💊 Overdose Management
Overdose with this medicine can cause severe neurological symptoms such as seizures, confusion, and encephalopathy, especially in patients with kidney impairment. If an overdose is suspected, stop the infusion and seek emergency medical care immediately. Treatment is supportive and may include monitoring of vital signs, kidney function, and neurological status. In severe cases, hemodialysis may help remove the medicine from the blood, because cefepime is dialyzable. There is no specific antidote.
⏰ Missed Dose
This medicine is given by a healthcare professional, so a missed dose is unlikely to happen at home. If you miss a scheduled infusion appointment, contact your doctor or clinic as soon as possible to reschedule. Do not try to catch up by taking extra doses or self-administering the medicine. Your treatment schedule will be adjusted by your healthcare team.
Additional Safety Advice
This medicine must only be given by a doctor or nurse in a clinic or hospital setting. Before the first dose, tell your doctor if you have ever had an allergic reaction to penicillin, amoxicillin, or any cephalosporin antibiotic. Inform your healthcare team about all other medicines you take, especially aminoglycosides, loop diuretics, probenecid, and blood thinners. Your kidney function will be checked before and during treatment because the dose often needs adjustment. Do not stop treatment early even if you feel better, because incomplete treatment can allow the infection to return and can promote antibiotic resistance. Report diarrhea that becomes watery or bloody, any new rash, swelling of the face or throat, difficulty breathing, or unusual bruising. Avoid alcohol during treatment because it can worsen nausea and dizziness. Keep all follow-up appointments so your doctor can monitor your response and adjust the plan if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects such as seizures and confusion. Kidney function should be checked before and during treatment, and the dose should be adjusted accordingly. Elderly patients should be monitored closely for any changes in mental status or balance.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this with your doctor before starting this medicine. It is generally used during pregnancy only when clearly needed for a serious bacterial infection. Your doctor will consider safer alternatives if appropriate. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine is sometimes used after surgery to treat or prevent serious infections. If you have recently had surgery, tell your surgeon and doctor about all medicines you are taking. The dose and duration will be decided based on the type of surgery and your kidney function.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine or have recently completed a course. Antibiotics can affect the balance of bacteria in the mouth and may interact with other medicines used during dental procedures. Your dentist may recommend delaying non-urgent dental work until you have recovered.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until your doctor says it is safe. Light activity such as short walks may be helpful if you feel up to it. If you have fever, dizziness, or difficulty breathing, rest and seek medical advice before exercising.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is usually given in a hospital or clinic, so you may need time off work during treatment. You may feel tired, dizzy, or unwell, so avoid driving or operating heavy machinery until you feel fully recovered. Discuss your work schedule with your doctor and employer. Most people can return to normal activities after completing treatment and recovering from the infection.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your clinical response, test results, and the type of infection. If you develop serious side effects such as a severe allergic reaction, seizures, or severe diarrhea, the doctor may stop the medicine immediately and change the treatment plan. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of antibiotic resistance and may lead to overgrowth of non-susceptible organisms such as fungi. Prolonged treatment may also increase the risk of kidney injury, low blood cell counts, and Clostridioides difficile-associated diarrhea. Regular monitoring of kidney function, blood counts, and clinical response is important during extended therapy. When used appropriately for a defined duration, the risk of long-term harm is low.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infecting organism and its susceptibility, other antibiotics such as ceftriaxone, piperacillin-tazobactam, or meropenem may be used.
Evidence: Well-establishedFor some infections, draining an abscess or removing an infected device is necessary in addition to antibiotics.
Evidence: Well-establishedRest, fluids, fever control, and oxygen therapy may be needed along with antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are due for any vaccines, tell your doctor. Live vaccines should generally be avoided during serious infections and while you are unwell. Your doctor will advise on the best timing.
📦 Storage Guide
✅ DO
Store the unopened vial at room temperature between 20°C and 25°C.
❌ DON'T
Do not freeze the unopened vial.
✅ DO
Protect the vial from light and moisture.
❌ DON'T
Do not store in direct sunlight or in a bathroom cabinet.
✅ DO
Keep the vial in its original carton until use.
❌ DON'T
Do not transfer the powder to another container.
✅ DO
Use the reconstituted solution within the time recommended by the manufacturer or pharmacy.
❌ DON'T
Do not use the solution if it is cloudy or contains particles.
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, it is usually given in a hospital or clinic, so travel is generally not recommended during active treatment. If your doctor approves travel between doses, carry the medicine in its original packaging with the prescription and a letter from your doctor. Keep it at the recommended temperature and protect it from extreme heat or cold. Check airline and customs rules for carrying injectable medicines. Always have a copy of your medical records and emergency contact information with you.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24 to 72 hours after starting treatment. However, the full course must be completed as prescribed, even if you feel better earlier.
A: This medicine is given intravenously by a healthcare professional, usually in a hospital or clinic. In some cases, it may be given through an outpatient parenteral antibiotic therapy program, but only under medical supervision.
A: Contact your doctor or clinic as soon as possible to reschedule. Do not try to self-administer or double the dose.
A: The dose may need to be adjusted if you have kidney disease. Your doctor will check your kidney function and decide the appropriate dose and schedule.
A: It is best to avoid alcohol during treatment because it can worsen nausea, dizziness, and stomach upset.
A: It may be used in pregnancy if a serious bacterial infection requires treatment and safer alternatives are not suitable. Your doctor will weigh the benefits and risks.
🤔 Common Patient Concerns
🔄 Substitutes for cefoxitin 1000mg injection
View AllAlternative brands with exact same active ingredient:
-
megapime 1000mg injectionAlkem Laboratories Ltd ₹84.38 71.8% CHEAPER
-
biopime 1000mg injectionBiochem Pharmaceutical Industries ₹98.14 67.2% CHEAPER
-
forpar 1000mg injectionCipla Ltd ₹123.75 58.6% CHEAPER
-
cepime 1000mg injectionAlembic Pharmaceuticals Ltd ₹129.91 56.6% CHEAPER
-
corpime 1000mg injectionCoral Pharmaceuticals P Ltd ₹139.69 53.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against certain bacteria. It does not treat viral infections such as colds or flu. - Myth: You can stop this medicine as soon as you feel better.
Fact: Stopping early can allow the infection to return and can lead to antibiotic resistance. Always complete the full course as prescribed. - Myth: This medicine is safe for everyone.
Fact: People with severe allergies to cephalosporins or penicillins should not receive this medicine. Kidney function also affects dosing. - Myth: This medicine can be taken as a pill instead of an injection.
Fact: This medicine is formulated for intravenous use only. It is not available as an oral tablet in this strength and form. - Myth: Antibiotics like this one weaken the immune system.
Fact: This medicine kills susceptible bacteria and helps the body fight the infection. It does not weaken the immune system.
🔄 Alternative Options
Generic Alternatives
- Cefepime 1000mg injection
Brand Alternatives
- Adpime 1000mg injection