Axipime S 1000mg/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, tongue, or throat.
- Severe, persistent, or bloody diarrhea.
- Seizures or sudden confusion.
- Decreased urine output or swelling in the legs.
- Severe skin rash with peeling or blisters.
- Unusual bleeding or bruising.
- High fever that does not improve with treatment.
If experiencing severe symptoms, call emergency services immediately.
What is lyfipime sb injection used for?
This medicine is a combination antibiotic injection containing cefepime and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and preventing them from destroying the antibiotic. It must be given by a healthcare professional.
- Generic Name: Cefepime (1000mg) + Sulbactam (500mg)
- Manufacturer: Hetero Drugs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 lyfipime sb injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त एंटीबायोटिक इंजेक्शन है जिसमें सेफेपाइम और सल्बैक्टम शामिल हैं। इसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों जैसे मूत्र मार्ग संक्रमण, निमोनिया, त्वचा संक्रमण और पेट के संक्रमण के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारती है और उन्हें नष्ट करने से रोकती है। यह केवल डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है। इसे घर पर स्वयं न लगाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, दस्त, जी मिचलाना, उल्टी, दाने, सिरदर्द और बुखार शामिल हैं। गंभीर दुष्प्रभावों में तेज एलर्जी, गंभीर दस्त, दौरे और गुर्दे की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह इंजेक्शन दिया जाए, अपने डॉक्टर को अपनी सभी एलर्जी, गुर्दे या लीवर की बीमारी के बारे में बताएं। इलाज के दौरान शराब न पिएं। पूरा कोर्स पूरा करें भले ही आप बेहतर महसूस करें। तेज दस्त, दाने, सूजन या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर को सूचित करें।
💊 lyfipime sb injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and urinary tract infections caused by susceptible Gram-negative bacteria, including some beta-lactamase-producing strains.","evidence":"Well-established"},{"condition":"Hospital-acquired and ventilator-associated pneumonia","description":"Prescribed for severe lung infections acquired in hospital settings when susceptible organisms are suspected or confirmed.","evidence":"Well-established"},{"condition":"Complicated skin and soft tissue infections","description":"Used for deep skin infections, abscesses, and surgical wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Given as part of therapy for complicated abdominal infections, often alongside surgical drainage.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Used as empiric therapy in cancer patients with fever and low white blood cell counts, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Complicated bacteremia","description":"Used to treat bloodstream infections caused by susceptible organisms when cefepime is appropriate.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Occasionally used off-label for surgical prophylaxis in patients with specific beta-lactam allergies or resistance concerns, but this is not a standard approved indication.","evidence":"Limited"},{"condition":"Meningitis caused by susceptible Gram-negative bacteria","description":"Cefepime has been used off-label for some cases of bacterial meningitis, but combination with sulbactam is not standard for this indication.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms.
Also treats: Complicated urinary tract infections, Hospital-acquired pneumonia, Complicated skin and soft tissue infections, Intra-abdominal infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime (1000mg) + Sulbactam (500mg) |
| Brand Name | lyfipime sb injection |
| Manufacturer | Hetero Drugs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. After reconstitution, the solution should be used within the time specified by the manufacturer, typically within a few hours if stored at room temperature or up to 24 hours if refrigerated. Follow the specific instructions provided with the product. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored as directed. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information for this specific combination product. Guidelines for cefepime use exist for various infections, but sulbactam combination is not universally recommended by WHO for all indications. |
| ICMR Guideline | Not established from the available information for this specific combination product. ICMR guidelines may recommend cefepime for certain infections, but the combination with sulbactam is not specifically addressed in publicly available summaries. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefepime is a fourth-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis and death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes, protecting cefepime from enzymatic degradation and extending its activity against some beta-lactamase-producing bacteria. Together, they provide broader coverage against susceptible organisms.
Mechanism Steps
💡 How to Take lyfipime sb injection
Strength: Injection: Cefepime 1000 mg + Sulbactam 500 mg per vial.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the type and severity of infection, the patient's kidney function, and other clinical factors. Typical adult doses of cefepime range from 1 gram to 2 grams every 8 to 12 hours, but the addition of sulbactam and the specific ratio in this product means the prescriber will determine the exact dose. For severe infections, higher doses or more frequent administration may be used. In patients with kidney impairment, the dose and/or interval must be adjusted. This medicine is for parenteral use only and must be given by a healthcare professional. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination product. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can increase the risk of side effects such as seizures. Dose adjustment based on kidney function is often necessary. Close monitoring is recommended. |
| Renal Impairment | Dose adjustment is required in patients with impaired kidney function. The dose and/or dosing interval should be modified based on creatinine clearance. In severe renal impairment, the dose may need to be reduced or the interval extended. Consult a clinician for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is typically required for hepatic impairment alone. However, patients with liver disease should be monitored for any signs of worsening liver function. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication, severity of infection, and renal function. It must be determined by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of lyfipime sb injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Loop diuretics | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Vancomycin | Moderate | |
| Amphotericin B | Moderate | |
| Oral contraceptives | Minor | |
| Live bacterial vaccines | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Other nephrotoxic drugs (e.g., amphotericin B, vancomycin)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it may increase the risk of liver toxicity and worsen side effects such as nausea, vomiting, and dizziness. It can also impair judgment and immune response, which may slow recovery from infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefepime, sulbactam, other cephalosporins, or penicillins.","Previous anaphylactic reaction to beta-lactam antibiotics.","Use in patients with a history of severe allergic reaction to any component of the formulation."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Before starting therapy, inquire about previous beta-lactam allergies.","Clostridioides difficile-associated diarrhea may occur and can range from mild to life-threatening. Consider this diagnosis if diarrhea develops.","Seizures have been reported, particularly in patients with renal impairment. Adjust dose in kidney disease.","Use with caution in patients with a history of gastrointestinal disease, especially colitis.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Monitor kidney function closely when used with other nephrotoxic drugs.","This medicine is for injection only and must be administered by a healthcare professional."]
🤱 Lactation Safety
Cefepime and sulbactam are excreted in human milk in low amounts. Caution is advised when administering to a breastfeeding mother. The benefits of treatment should be weighed against the potential risks to the infant. Monitor the baby for diarrhea, thrush, or rash.
💊 Overdose Management
Overdose with this medicine can cause severe neurological effects, including seizures and encephalopathy, especially in patients with kidney impairment. There is no specific antidote. Treatment is supportive and symptomatic. Cefepime and sulbactam can be removed by hemodialysis. In case of suspected overdose, seek emergency medical care immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely to occur at home. If you miss a scheduled appointment for your injection, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a trained healthcare professional in a setting equipped to manage allergic reactions. Before receiving this medicine, inform your doctor about any allergy to penicillins, cephalosporins, or other antibiotics, and about any kidney or liver problems. Do not attempt to self-administer this injection. Complete the full course as prescribed, even if you feel better, to reduce the risk of resistance. Report severe diarrhea, rash, swelling, or breathing difficulty immediately. Avoid alcohol during treatment because it may worsen side effects and strain the liver. Keep all follow-up appointments for monitoring kidney function, blood counts, and clinical response.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of neurotoxicity, including seizures. Dose adjustment based on renal function is often necessary. Close monitoring for side effects is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. It is classified as Pregnancy Category B, but use only if clearly needed. Effective contraception is recommended during treatment if you are of childbearing age.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. If you have recently had surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may affect the choice of antibiotics for dental procedures or interact with other medications. No specific precautions are typically required, but good communication is important.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you have recovered and your doctor approves. Light activity like walking may be beneficial, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work or arrange for transportation. You may experience fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and test results. If you experience severe side effects, contact your doctor immediately; they will decide whether to continue, adjust, or stop the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of resistant bacteria or fungi, and rarely, blood cell abnormalities or liver enzyme changes. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of kidney function, liver function, and blood counts is advised for patients on extended treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics like piperacillin-tazobactam or meropenem may be used.
Evidence: Well-establishedFor abscesses or infected collections, surgical drainage may be necessary in addition to antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics like this medicine may reduce the effectiveness of live bacterial vaccines. Avoid receiving live bacterial vaccines during treatment and for a short period after. Inactivated vaccines are generally safe to administer, but consult your doctor for timing.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (20-25°C).
❌ DON'T
Do not freeze the powder or the reconstituted solution.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not use if the powder is discolored or the vial is damaged.
✅ DO
Use the reconstituted solution within the time specified by the manufacturer.
❌ DON'T
Do not store reconstituted solution for longer than recommended.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting, so travel is not typically applicable. If you are prescribed this medicine as an outpatient, you will need to visit a healthcare facility for each dose. Carry your prescription and medical records with you. If you are traveling, ensure you have access to a healthcare facility that can administer the injection. Store the medicine as directed by the manufacturer, and do not expose it to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after the first dose, but it may take several days for full effect. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Mild side effects like nausea may be managed, but serious reactions require urgent medical attention.
A: It can affect kidney function, especially if you have pre-existing kidney disease. Your doctor will monitor your kidney function and adjust the dose if needed.
🤔 Common Patient Concerns
🔄 Substitutes for lyfipime sb injection
View AllAlternative brands with exact same active ingredient:
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befsul 1.5gm injectionBayberry Pharmaceuticals Pvt Ltd ₹273.00 118.4% COSTLIER
-
zardpime s injectionVibcare Pharma Pvt Ltd ₹325.00 160% COSTLIER
-
axipime s 1000mg/500mg injectionAxis Life Science Pvt Ltd ₹340.00 172% COSTLIER
-
supime 1000 mg/500 mg injectionVenus Remedies Ltd ₹345.00 176% COSTLIER
-
inpime 1000mg/500mg injectionProfic Organic Ltd ₹348.00 178.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against certain susceptible bacteria. It is not effective against viruses or all bacterial strains. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed to prevent resistance and relapse. - Myth: This medicine is safe to self-administer at home.
Fact: This is an injectable prescription antibiotic that must be given by a healthcare professional in a supervised setting.
🔄 Alternative Options
Generic Alternatives
- Cefepime injection
- Sulbactam injection