Cefixime 400mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or persistent diarrhea, which may contain blood or mucus.
- Signs of a severe allergic reaction: rash, itching, swelling of the face, lips, or throat, difficulty breathing.
- Yellowing of the skin or eyes (jaundice).
- Decreased urine output or swelling in the legs or feet.
- Unusual bleeding or bruising.
- High fever that does not improve after 48 hours of treatment.
If experiencing severe symptoms, call emergency services immediately.
What is cefolac 400mg tablet used for?
This medicine is an antibiotic used to treat bacterial infections such as respiratory tract infections, urinary tract infections, and gonorrhea. It works by killing bacteria.
- Generic Name: Cefixime
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefolac 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक है जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि श्वसन पथ के संक्रमण, मूत्र पथ के संक्रमण, और गोनोरिया। यह बैक्टीरिया को मारकर काम करती है। यह वायरल संक्रमणों जैसे सर्दी-जुकाम या फ्लू के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, मतली, पेट दर्द और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें गंभीर एलर्जी प्रतिक्रिया, आंतों का गंभीर संक्रमण, और गुर्दे की समस्याएं शामिल हो सकती हैं। यदि आपको गंभीर दस्त, दाने, खुजली, सूजन, या सांस लेने में कठिनाई हो तो तुरंत चिकित्सा सहायता लें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खुराक न छोड़ें और बेहतर महसूस होने पर भी कोर्स पूरा करें। पेट की परेशानी कम करने के लिए इसे भोजन के साथ लें। दिन भर पर्याप्त पानी पिएं। इस दवा के साथ शराब न लें। यदि आपको गुर्दे या लीवर की समस्या है या एंटीबायोटिक से एलर्जी है तो अपने डॉक्टर को बताएं।
💊 cefolac 400mg tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat bacterial infections of the throat, sinuses, and lungs, such as pharyngitis, sinusitis, and bronchitis.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against many bacteria that cause bladder and kidney infections.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Used as a single-dose treatment for uncomplicated gonorrhea caused by Neisseria gonorrhoeae.","evidence":"Well-established"},{"condition":"Otitis media","description":"Sometimes prescribed for middle ear infections in children, though dosing is different.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used as an alternative to other antibiotics for early Lyme disease, but not first-line.","evidence":"Limited"},{"condition":"Typhoid fever","description":"May be used in some regions where susceptibility is confirmed, but resistance is common.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Gonorrhea, Otitis media
📋 Drug Information
| Generic Name(s) | Cefixime |
| Brand Name | Abixim |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in the original container. |
| Shelf Life | Typically 2 years from the date of manufacture. Check the expiry date on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to specific proteins called penicillin-binding proteins (PBPs) inside the bacterial cell wall. This binding stops the bacteria from building a strong cell wall, which causes the bacteria to break apart and die. Because it targets a structure that human cells do not have, it is selectively toxic to bacteria.
Mechanism Steps
💡 How to Take cefolac 400mg tablet
Strength: Cefixime 400mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400mg taken once daily or 200mg taken twice daily, depending on the type and severity of the infection. For uncomplicated gonorrhea, a single 400mg dose is often used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and may require dose adjustment. Consult a doctor for personalized dosing. |
| Renal Impairment | In patients with kidney impairment, dose adjustment is required. For creatinine clearance less than 20 mL/min, a reduced dose is recommended. Consult a doctor for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is recommended for liver impairment, but use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 400mg. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefolac 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Carbamazepine | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Carbamazepine
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may worsen stomach upset and dizziness. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to cefixime or other cephalosporin antibiotics","Severe allergy to penicillin (cross-reactivity possible)","History of severe allergic reaction to any beta-lactam antibiotic"]
⚠️ Warnings & Precautions
["Use with caution in patients with kidney disease; dose adjustment may be needed.","May cause Clostridium difficile-associated diarrhea; report severe diarrhea.","May reduce effectiveness of oral contraceptives; use backup contraception.","Not effective against viral infections; do not use for colds or flu.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose may cause nausea, vomiting, and diarrhea. Seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop taking it early, even if you feel better. Take it with food to reduce stomach upset. Drink plenty of water throughout the day. Avoid alcohol while taking this medicine as it may worsen side effects. Inform your doctor if you have kidney problems, liver problems, or a history of allergies to antibiotics. Do not share this medicine with others. Keep it out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and may require a lower dose. They should be monitored for side effects and signs of allergic reactions.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. It is generally considered safe but should only be used if clearly needed.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may need to be stopped before certain procedures.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light exercise if you feel up to it, but avoid strenuous activities if you have fever or feel weak. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness in some people. If you experience these effects, avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine early unless your doctor tells you to. Complete the full course as prescribed. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and disruption of normal gut bacteria. It is not intended for prolonged use unless prescribed for a specific chronic infection. Regular monitoring of kidney function may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics like amoxicillin or azithromycin may be used.
Evidence: Well-establishedRest, fluids, and fever reducers can help manage symptoms while the antibiotic works.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for a vaccine, inform your doctor that you are taking this antibiotic.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue your regular dosing schedule as close as possible. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for cefolac 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
zifi 400mg tabletFDC Ltd ₹97.50 22% CHEAPER
-
topcef 400mg tabletTorrent Pharmaceuticals Ltd ₹108.17 13.5% CHEAPER
-
cefix 400mg tabletCipla Ltd ₹115.57 7.5% CHEAPER
-
cefcea 400mg tablet dtAlcea Biotech Pvt Ltd ₹120.00 4% CHEAPER
-
hifen 400 tabletHetero Drugs Ltd ₹164.91 31.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the flu.
Fact: This medicine only works against bacterial infections. It is not effective against viruses. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course to prevent the infection from returning and to avoid antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Cefixime 400mg tablet (generic)
Brand Alternatives
- Akraxime 400mg tablet