Avoxime O Dry Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing, or severe skin rash.
- Signs of tendon rupture: sudden pain, swelling, or inability to move a joint, especially the Achilles tendon.
- Severe diarrhea with blood or mucus, fever, and abdominal cramps (possible C. difficile infection).
- Seizures, confusion, hallucinations, or severe dizziness.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (liver problems).
- Decreased urine output, swelling in legs, or flank pain (kidney problems).
- Numbness, tingling, or burning in hands or feet (peripheral neuropathy).
If experiencing severe symptoms, call emergency services immediately.
What is ceflonix-o dry syrup orange used for?
This medicine is a combination antibiotic dry syrup containing cefixime and ofloxacin. It is used to treat certain bacterial infections when prescribed by a doctor. It works by killing bacteria through two different mechanisms. It is not effective against viral infections and should only be used under medical supervision.
- Generic Name: Cefixime + Ofloxacin
- Manufacturer: Medinix Pharmaceutical Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ceflonix-o dry syrup orange के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम और ऑफ्लोक्सासिन का संयोजन है, जिसका उपयोग कुछ जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा और अन्य जगहों के संक्रमण में प्रभावी हो सकती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और वायरल संक्रमण जैसे सर्दी-जुकाम के लिए यह काम नहीं करती।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, टेंडन टूटना, दौरे और गंभीर दस्त हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और पूरा कोर्स पूरा करें। दवा को भोजन के साथ लें ताकि पेट की परेशानी कम हो। पर्याप्त पानी पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ इस दवा को न लें, कम से कम 2 घंटे का अंतर रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 ceflonix-o dry syrup orange Uses & Benefits
[{"condition":"Respiratory tract infections","description":"This medicine may be prescribed for bacterial infections of the upper or lower respiratory tract, such as sinusitis, pharyngitis, tonsillitis, and bronchitis, when a clinician determines that combination therapy is appropriate.","evidence":"Limited evidence for combination; individual agents are well-established."},{"condition":"Urinary tract infections","description":"It may be used to treat complicated or recurrent urinary tract infections caused by susceptible bacteria, but only under medical supervision.","evidence":"Limited evidence for combination; individual agents are well-established."},{"condition":"Typhoid fever","description":"Cefixime and ofloxacin are both used individually for enteric fever, and this combination may be prescribed in some settings, though combination therapy is not universally recommended.","evidence":"Limited evidence for combination; individual agents are well-established."},{"condition":"Skin and soft tissue infections","description":"This medicine may be used for bacterial skin infections such as cellulitis or abscesses when the causative organism is susceptible to both components.","evidence":"Limited evidence for combination; individual agents are well-established."}]
Off-label uses: [{"condition":"Gonorrhea","description":"Ofloxacin has been used off-label for uncomplicated gonorrhea, but combination with cefixime is not standard and should only be considered by a specialist.","evidence":"Limited"},{"condition":"Prostatitis","description":"Fluoroquinolones like ofloxacin are sometimes used for chronic bacterial prostatitis, but the combination with cefixime is not established.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Typhoid fever, Skin and soft tissue infections
📋 Drug Information
| Generic Name(s) | Cefixime + Ofloxacin |
| Brand Name | Abixim O Tablet |
| Manufacturer | Medinix Pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Fluoroquinolone) |
| Route of Administration | Oral |
| Storage | Store the dry powder at room temperature, between 15°C and 30°C, away from direct sunlight and moisture. After reconstitution with water, store the syrup in a refrigerator at 2°C to 8°C and use within the period specified by the manufacturer, typically 7 to 14 days. Do not freeze the reconstituted syrup. Keep the bottle tightly closed and out of the reach of children. |
| Shelf Life | The shelf life of the dry powder is typically 24 months from the date of manufacture, but refer to the packaging for the exact expiry date. Once reconstituted, the syrup should be used within 7 to 14 days when stored in a refrigerator. |
| WHO Guideline | Not established from the available information. The World Health Organization does not specifically recommend this fixed-dose combination for any indication. Individual antibiotics are included in WHO essential medicines lists for specific infections. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not issued specific guidelines for this combination. Clinicians should refer to national antibiotic policies and local resistance patterns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with distinct mechanisms. Cefixime, a third-generation cephalosporin, binds to penicillin-binding proteins and inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, leading to cell lysis and death. Ofloxacin, a fluoroquinolone, inhibits DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, resulting in rapid bacterial death. The combination provides a broader spectrum of activity against gram-positive and gram-negative bacteria, though it is not effective against viruses.
Mechanism Steps
💡 How to Take ceflonix-o dry syrup orange
Strength: This medicine is available as a dry syrup that, after reconstitution, provides cefixime 50 mg per 5 mL and ofloxacin 50 mg per 5 mL. The dry powder must be reconstituted with the specified amount of water as directed on the label or by the pharmacist.
Dosage Information
| Adult Dosage | The adult dosage of this medicine is determined by the treating physician based on the type and severity of the infection, the patient's renal and hepatic function, and other individual factors. Typically, the combination is dosed every 12 hours, but the exact strength and frequency must be individualized by a qualified clinician. Do not self-medicate or adjust the dose without medical advice. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This combination is generally not recommended for children under 18 years due to the risk of cartilage and tendon damage associated with fluoroquinolones. If used in specific situations, the dose must be determined by a pediatrician based on weight and clinical condition. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function, as both cefixime and ofloxacin are excreted by the kidneys. The dose must be individualized by a qualified clinician. Elderly patients are also at higher risk of tendon rupture, central nervous system effects, and drug interactions. Close monitoring is advised. |
| Renal Impairment | In patients with renal impairment, dose adjustment is necessary. For cefixime, the dose may be reduced or the dosing interval extended when creatinine clearance is below 20 mL/min. For ofloxacin, the dose should be adjusted based on creatinine clearance, with a reduced dose or increased interval. The exact adjustment must be determined by a qualified clinician. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Hepatic Impairment | No specific dose adjustment is typically required for mild to moderate hepatic impairment, as neither drug is extensively metabolized by the liver. However, in severe hepatic impairment, caution is advised, and the dose must be individualized by a qualified clinician. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Maximum Daily Dose | The maximum daily dose of this medicine is not fixed and depends on the prescribed strength and frequency. It must not exceed the dose recommended by the treating physician. Do not exceed the prescribed dose. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ceflonix-o dry syrup orange
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Warfarin | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Major | |
| Probenecid | Moderate | |
| Oral antidiabetic agents | Moderate | |
| Phenytoin | Moderate | |
| Cyclosporine | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc, or magnesium-containing products
- Warfarin
- Theophylline
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Corticosteroids
⚡ Moderate Interactions
- Probenecid
- Oral antidiabetic agents
- Phenytoin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and stomach upset while taking this medicine. It is advisable to avoid alcohol during treatment to prevent these effects and to support recovery from infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to cefixime, ofloxacin, other cephalosporins, or fluoroquinolones.","History of tendon disorders associated with fluoroquinolone use.","Myasthenia gravis, as fluoroquinolones may exacerbate muscle weakness.","Pregnancy, unless the benefit clearly outweighs the risk.","Breastfeeding, due to potential serious adverse effects in the infant.","Children and adolescents under 18 years, as fluoroquinolones may affect cartilage development.","Patients with a history of seizures or CNS disorders, as fluoroquinolones can lower seizure threshold."]
⚠️ Warnings & Precautions
["This medicine should only be used for bacterial infections proven or strongly suspected to be caused by susceptible organisms.","Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if any signs of allergy appear.","Clostridioides difficile-associated diarrhea can occur during or after antibiotic therapy. If suspected, seek medical advice.","Fluoroquinolones can cause tendon inflammation and rupture, especially in older adults, those with kidney disease, or those on corticosteroids. Stop the medicine and consult a doctor if tendon pain occurs.","Peripheral neuropathy has been reported with fluoroquinolones. Discontinue if symptoms develop.","Central nervous system effects, including seizures, confusion, and hallucinations, may occur. Use with caution in patients with CNS disorders.","Avoid excessive sun exposure, as fluoroquinolones can cause photosensitivity reactions.","Do not use this medicine to treat viral infections, as it is ineffective and may promote resistance.","Complete the full course of therapy as prescribed, even if symptoms improve, to prevent recurrence and resistance."]
🤱 Lactation Safety
Both cefixime and ofloxacin are excreted in human breast milk. Cefixime is generally considered compatible with breastfeeding, but ofloxacin may cause serious adverse effects in the nursing infant, including joint problems and central nervous system effects. Therefore, this combination is not recommended during breastfeeding unless the healthcare provider determines it is essential. If used, monitoring of the infant for diarrhea, thrush, or other symptoms is advised.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, dizziness, and possibly seizures. There is no specific antidote. Treatment should be symptomatic and supportive. In case of overdose, seek immediate medical attention. Gastric lavage may be considered if the overdose is recent and significant. Monitor vital signs, renal function, and neurological status. Hemodialysis may be considered for ofloxacin overdose in patients with renal failure, but it is not effective for cefixime.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you start feeling better, because doing so can allow the infection to return and may promote antibiotic resistance. Take this medicine with food to reduce stomach upset. Drink plenty of water throughout the day to stay hydrated. Avoid taking antacids, iron supplements, or multivitamins containing zinc or magnesium within two hours before or after this medicine, as they can interfere with its absorption. Do not consume alcohol while taking this medicine, as it may increase the risk of dizziness and stomach upset. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before using this medicine. Keep this medicine out of the reach of children. Store the dry powder at room temperature and use the reconstituted syrup within the recommended period, typically within seven to fourteen days when kept in a refrigerator. Do not use this medicine for any other condition without consulting a doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney impairment, tendon rupture, and central nervous system effects from this medicine. Dose adjustment based on renal function is often necessary. They should be monitored closely for side effects and drug interactions. Falls and fractures may be more likely if dizziness occurs. It is important to use the lowest effective dose for the shortest duration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. Ofloxacin is not recommended during pregnancy due to potential risk to the developing fetus. Alternative antibiotics may be safer. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
After surgery, this medicine may be prescribed if there is a risk of bacterial infection. However, the combination is not routinely used for surgical prophylaxis. If you are taking this medicine after surgery, inform your surgeon and anesthesiologist. Monitor for signs of infection and side effects. Follow your surgeon's instructions regarding wound care and activity restrictions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. There is no specific contraindication, but the dentist should be aware of your medication to avoid potential interactions with other drugs used during dental work. Maintain good oral hygiene to prevent infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous exercise or activities that could increase the risk of tendon injury, especially if you are older or have kidney problems. If you experience joint pain or swelling, stop exercising and consult your doctor. Light activities like walking are generally safe, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion in some people. Avoid driving or operating heavy machinery until you know how it affects you. If your work involves fine motor skills or alertness, take extra precautions. Most people can continue their normal daily activities, but it is important to rest and allow your body to recover from the infection.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to a relapse of the infection and promote antibiotic resistance. However, if you experience serious side effects such as severe allergic reactions, tendon pain, seizures, or severe diarrhea, stop the medicine immediately and seek medical attention. Your doctor will advise you on whether to continue or switch to an alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, disruption of normal gut flora, and an increased risk of fungal infections. Prolonged use of fluoroquinolones has been associated with persistent peripheral neuropathy, tendon damage, and central nervous system effects. Regular monitoring of renal and liver function may be required if used for extended periods. This medicine should only be used for the shortest duration necessary to treat the infection.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Using a single antibiotic that the bacteria is sensitive to can be more effective and reduce side effects.
Evidence: Well-establishedRest, hydration, and symptomatic treatment can help while the infection resolves, especially for mild infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for a few days after completing the course. Inactivated vaccines are generally safe to administer. Consult your doctor for specific advice regarding vaccination timing.
📦 Storage Guide
✅ DO
Store the dry powder at room temperature (15-30°C).
❌ DON'T
Do not expose to direct sunlight or moisture.
✅ DO
After reconstitution, store the syrup in the refrigerator (2-8°C).
❌ DON'T
Do not freeze the reconstituted syrup.
✅ DO
Keep the bottle tightly closed and out of reach of children.
❌ DON'T
Do not use after the expiry date or after the recommended period post-reconstitution.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Keep the dry powder at room temperature and protect it from extreme heat or moisture. If you have already reconstituted the syrup, store it in a cool place or refrigerator if available, and use it within the recommended period. For air travel, carry it in your hand luggage to avoid temperature extremes in checked baggage. If you are crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Check the customs regulations of your destination country regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed, even if symptoms improve.
A: It is best to separate this medicine from milk and other dairy products by at least 2 hours, as calcium can reduce the absorption of ofloxacin.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This combination is generally not recommended for children under 18 years due to the risk of joint and tendon problems. Consult a pediatrician for appropriate alternatives.
A: It is advisable to avoid alcohol as it may increase dizziness, drowsiness, and stomach upset.
🤔 Common Patient Concerns
🔄 Substitutes for ceflonix-o dry syrup orange
View AllAlternative brands with exact same active ingredient:
-
oflomac cx dry syrupMacleods Pharmaceuticals Pvt Ltd ₹43.13 25.8% CHEAPER
-
Tosif O SyrupAvunu Life Sciences ₹45.00 22.6% CHEAPER
-
Tefloc O Dry SyrupTesni Pharmaceuticals ₹51.56 11.3% CHEAPER
-
safixime o dry syrupSafe Life Care ₹54.38 6.5% CHEAPER
-
vycocef o dry syrupAlentra Healthcare ₹60.94 4.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection, including viral ones like the common cold.
Fact: This medicine is effective only against specific bacterial infections. It does not treat viral infections such as the common cold or flu. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full prescribed course to ensure the infection is fully treated and to prevent antibiotic resistance. - Myth: This medicine is safe for children.
Fact: This combination is generally not recommended for children under 18 years due to the risk of joint and tendon problems associated with fluoroquinolones. - Myth: Taking this medicine with milk is fine.
Fact: Dairy products can reduce the absorption of ofloxacin. Separate this medicine from dairy by at least 2 hours.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Ofloxacin dry syrup (generic)
Brand Alternatives
- Avoxime O Dry Syrup