Azib-Cef Dry Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe watery diarrhea or bloody stools
- Signs of allergic reaction: rash, itching, swelling of face or throat, difficulty breathing
- Yellowing of skin or eyes, dark urine, severe fatigue
- Persistent vomiting or inability to keep fluids down
- High fever that does not improve after 48 hours
- Unusual bleeding or bruising
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is spazime-az suspension used for?
This medicine is a combination antibiotic dry syrup containing cefixime and azithromycin, used to treat bacterial infections in children and adults who cannot swallow tablets. It works by killing bacteria through two different mechanisms.
- Generic Name: Cefixime (50mg/5ml) + Azithromycin (100mg/5ml)
- Manufacturer: Spark Medicare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 spazime-az suspension के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम और एज़िथ्रोमाइसिन का संयोजन है, जिसका उपयोग बच्चों और वयस्कों में बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह कान के संक्रमण, साइनसाइटिस, गले के संक्रमण, निमोनिया और मूत्र मार्ग के संक्रमण में प्रभावी है। यह दवा बैक्टीरिया को मारती है और संक्रमण को फैलने से रोकती है। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के कुछ सामान्य दुष्प्रभाव हो सकते हैं जैसे दस्त, जी मिचलाना, उल्टी, पेट दर्द और दाने। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन अगर सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त या त्वचा पर छाले हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और एलर्जी के बारे में बताएं। दवा को सही मात्रा में मापकर दें और पूरा कोर्स पूरा करें। बिना डॉक्टर की सलाह के दवा बंद न करें। दवा को बच्चों की पहुंच से दूर रखें। घोल बनाने के बाद फ्रिज में रखें और निर्दिष्ट दिनों के भीतर उपयोग करें।
💊 spazime-az suspension Uses & Benefits
[{"condition":"Acute otitis media","description":"This medicine is used to treat middle ear infections caused by susceptible bacteria such as Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Community-acquired pneumonia","description":"It may be prescribed for mild to moderate pneumonia caused by susceptible organisms, often when oral therapy is appropriate.","evidence":"Well-established"},{"condition":"Acute bacterial sinusitis","description":"This medicine can help clear sinus infections caused by bacteria such as Streptococcus pneumoniae and Moraxella catarrhalis.","evidence":"Well-established"},{"condition":"Pharyngitis and tonsillitis","description":"It is used to treat throat infections caused by susceptible bacteria, including Streptococcus pyogenes, when other antibiotics are not suitable.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"This medicine may be used for uncomplicated urinary tract infections caused by susceptible bacteria like Escherichia coli.","evidence":"Moderate"},{"condition":"Skin and soft tissue infections","description":"It can be prescribed for certain bacterial skin infections when the causative organism is susceptible to both components.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Bronchitis exacerbations","description":"Sometimes used for acute exacerbations of chronic bronchitis, though not a first-line choice.","evidence":"Limited"},{"condition":"Typhoid fever","description":"Cefixime component may be used off-label for enteric fever in some regions, but azithromycin combination is not standard.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Otitis media, Sinusitis, Pharyngitis, Pneumonia, Urinary tract infections
📋 Drug Information
| Generic Name(s) | Cefixime (50mg/5ml) + Azithromycin (100mg/5ml) |
| Brand Name | spazime-az suspension |
| Manufacturer | Spark Medicare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, away from direct sunlight. After reconstitution, store the syrup in the refrigerator (2-8°C) and use within the number of days specified on the label (usually 7 to 14 days). Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of the dry powder is typically 24 months from the date of manufacture. After reconstitution, the syrup should be used within 7 to 14 days as specified on the product label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms of action. Cefixime, a third-generation cephalosporin, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to weakened cell walls and bacterial death. Azithromycin, a macrolide antibiotic, binds to the 50S ribosomal subunit of susceptible bacteria and inhibits protein synthesis, thereby stopping bacterial growth and multiplication. Together, they provide a broader spectrum of activity against various gram-positive and gram-negative bacteria.
Mechanism Steps
💡 How to Take spazime-az suspension
Strength: Dry syrup containing cefixime 50 mg per 5 mL and azithromycin 100 mg per 5 mL after reconstitution.
Dosage Information
| Adult Dosage | The adult dose of this medicine is determined by the prescribing doctor based on the type and severity of infection, renal and hepatic function, and other factors. Typically, cefixime is dosed at 200-400 mg per day, and azithromycin at 250-500 mg per day, but the combination ratio in this product may require specific dosing. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination product. The dose depends on the child's weight and the severity of infection. Consult a pediatrician for appropriate dosing. Typically, cefixime is dosed at 8 mg/kg/day and azithromycin at 10 mg/kg/day, but this combination should only be used under medical supervision. |
| Elderly Dosage | Elderly patients may have reduced renal function and may require dose adjustment. Use with caution and monitor renal function. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment (creatinine clearance < 60 mL/min), dose adjustment of cefixime is required. Azithromycin does not require significant adjustment. Consult a doctor for appropriate dosing. |
| Hepatic Impairment | In patients with hepatic impairment, use with caution. Azithromycin is metabolized in the liver, and dose adjustment may be needed. Monitor liver function. Consult a doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed the recommended adult dose as prescribed by a doctor. For cefixime, the maximum is typically 400 mg per day; for azithromycin, 500 mg per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of spazime-az suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ergot alkaloids | Major | |
| Antacids | Moderate | |
| Carbamazepine | Moderate | |
| Digoxin | Moderate | |
| Cyclosporine | Moderate | |
| Oral contraceptives | Minor | |
| Theophylline | Minor |
🚨 Major Interactions
- Warfarin
- Ergot alkaloids (e.g., ergotamine)
- Live typhoid vaccine
⚡ Moderate Interactions
- Antacids containing aluminum or magnesium
- Carbamazepine
- Digoxin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol does not directly interact with cefixime or azithromycin, but it can worsen stomach upset and dizziness. It is advisable to avoid alcohol during treatment, especially if you experience side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, azithromycin, other cephalosporins, or macrolide antibiotics","History of severe allergic reaction to penicillins or cephalosporins","Concurrent use with ergot alkaloids","Severe hepatic impairment","Use of live typhoid vaccine within 24 hours"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment.","May cause Clostridioides difficile-associated diarrhea; monitor for severe diarrhea.","May cause allergic reactions; discontinue if rash or other allergic symptoms occur.","May prolong QT interval; use with caution in patients with cardiac conditions or electrolyte imbalances.","May reduce efficacy of oral contraceptives; use backup contraception.","Not recommended for viral infections; use only for bacterial infections.","Complete the full course as prescribed, even if symptoms improve."]
🤱 Lactation Safety
Cefixime is excreted in human breast milk in small amounts and is generally considered compatible with breastfeeding. Azithromycin is also excreted in breast milk and is considered safe for nursing infants. However, monitor the infant for diarrhea, thrush, or rash. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, diarrhea, and abdominal pain. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, contact a poison control center or emergency room immediately. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and electrolytes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up. Try to take the medicine at the same time each day to maintain consistent levels.
Additional Safety Advice
Before giving this medicine, inform your doctor about all medical conditions your child or you may have, especially kidney or liver disease, allergies to antibiotics, or a history of stomach problems. Do not use this medicine if you are allergic to cefixime, azithromycin, other cephalosporins, or macrolides. Always measure the dose accurately using the measuring spoon or cup provided with the product. Shake the reconstituted syrup well before each use. Do not skip doses or stop the course early, as this can lead to antibiotic resistance and treatment failure. If a dose is missed, follow the missed dose instructions provided by your doctor. Keep this medicine out of reach of children. Store the dry powder at room temperature and after reconstitution, store the syrup in the refrigerator and discard any unused portion after the specified number of days (usually 7 to 14 days, as directed on the label). Do not use this medicine for any other infection or share it with others. If symptoms do not improve within a few days or worsen, contact your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are more prone to side effects. Dose adjustment may be necessary. Monitor renal function and watch for signs of superinfection or allergic reactions. Use with caution.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both cefixime and azithromycin are generally considered safe in pregnancy when clearly needed, but the decision should be made by your doctor after weighing the benefits and risks.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. Antibiotics may interact with anesthetics or other medications used during surgery. Your doctor may advise you to stop the medicine temporarily or adjust the dose.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Antibiotics can affect the balance of oral bacteria and may increase the risk of oral thrush. Your dentist may recommend additional precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue in some people. Avoid strenuous exercise or activities requiring alertness if you experience these side effects. Light activity is generally fine, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, fatigue, or stomach upset, which can affect your ability to drive or operate machinery. If you experience these side effects, avoid driving or operating heavy machinery until you feel better. Most people can continue their normal daily activities with minor adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience a serious side effect such as a severe allergic reaction, severe diarrhea, or signs of liver problems, stop the medicine and seek immediate medical attention. Otherwise, complete the full course as prescribed.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless under strict medical supervision. Prolonged use can lead to antibiotic resistance, superinfections (such as oral thrush or C. difficile colitis), and rarely, liver or kidney problems. Regular monitoring of liver and kidney function may be required if used for extended periods. Always consult a doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used if azithromycin is not needed or not tolerated.
Evidence: Well-establishedMay be used for atypical infections or when cephalosporins are not suitable.
Evidence: Well-establishedAlternative for broader beta-lactamase coverage.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics like this medicine may reduce the efficacy of live bacterial vaccines such as the typhoid vaccine. Complete the antibiotic course before receiving live vaccines, or consult your doctor for appropriate timing. Inactivated vaccines are not affected.
📦 Storage Guide
✅ DO
Store dry powder at room temperature (15-30°C)
❌ DON'T
Do not refrigerate dry powder unless specified
✅ DO
Store reconstituted syrup in refrigerator (2-8°C)
❌ DON'T
Do not freeze the reconstituted syrup
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep the dry powder at room temperature and protect it from extreme heat or moisture. If the syrup is already reconstituted, carry it in a cool bag with an ice pack and store in a refrigerator at the destination. Carry a copy of your prescription to avoid customs issues. If crossing time zones, adjust dosing times gradually to maintain consistent intervals. Always check with your doctor before traveling with antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, this medicine can be taken with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
A: This medicine is commonly prescribed for children, but the dose must be determined by a pediatrician based on the child's weight and condition.
A: No, you must complete the full course as prescribed, even if symptoms improve, to prevent the infection from returning and to avoid antibiotic resistance.
🤔 Common Patient Concerns
🔄 Substitutes for spazime-az suspension
View AllAlternative brands with exact same active ingredient:
-
onixim az dry syrupOsvel Pharma ₹92.81 190.3% COSTLIER
-
deefix az dry syrupAndee Lifesciences ₹98.44 207.9% COSTLIER
-
arifix-az dry syrupSarian Healthcare ₹99.00 209.7% COSTLIER
-
kodixam az dry syrupKerwin Formulations ₹99.89 212.4% COSTLIER
-
Fixinex AZ Dry SyrupBionexa Organic ₹100.78 215.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: Antibiotics only work against bacteria. This medicine is not effective for viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course to prevent bacterial resistance and relapse. - Myth: This medicine can be shared with others who have similar symptoms.
Fact: Antibiotics are prescribed for specific infections and should never be shared.
🔄 Alternative Options
Generic Alternatives
- Cefixime + Azithromycin dry syrup (generic)
Brand Alternatives
- Azib-Cef Dry Syrup