cedcozine 1000mg injection - Uses, Price, Side Effects & Substitutes
What is cedcozine 1000mg injection used for?
Arzi 200mg Injection (Dacarbazine) is used to treat ANTI NEOPLASTICS. It contains Dacarbazine (1000mg), which Alkylating agent that methylates DNA at guanine residues, causing DNA cross-link. Always consult your doctor before use. Take as prescribed.
- Generic Name: Dacarbazine
- Manufacturer: Health Biotech Limited
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cedcozine 1000mg injection Uses & Benefits
Metastatic melanoma; Hodgkin lymphoma (as part of ABVD regimen); soft tissue sarcoma.
Off-label uses: Pancreatic neuroendocrine tumors; glioblastoma multiforme.
๐ Drug Information
| Generic Name(s) | Dacarbazine |
| Brand Name | Arzi 200mg Injection |
| Manufacturer | Health Biotech Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Intravenous injection or infusion. |
| Storage | Store at 2-8ยฐC; protect from light; reconstituted solution stable for 8 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Alkylating agent that methylates DNA at guanine residues, causing DNA cross-linking and strand breaks, inhibiting DNA replication and transcription.
Mechanism Steps
๐ก How to Take cedcozine 1000mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cedcozine 1000mg injection
โ Common Side Effects
- Nausea
- Vomiting
- Anorexia
- Myelosuppression (leukopenia, thrombocytopenia)
- Alopecia
- Injection site reactions
๐จ Serious Side Effects
- Severe myelosuppression
- Hepatotoxicity
- Anaphylaxis
- Hemolytic uremic syndrome
- Secondary malignancies
โ ๏ธ Rare Side Effects
- Photosensitivity
- Renal failure
- Pulmonary fibrosis
- Neurotoxicity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk due to enhanced anticoagulant effect. |
| Phenytoin | Major | Decreased phenytoin levels; monitor phenytoin concentrations. |
| Fluvoxamine | Major | Increased dacarbazine toxicity due to CYP1A2 inhibition. |
| Disulfiram | Major | Increased dacarbazine toxicity due to CYP2E1 inhibition. |
| Live vaccines | Moderate | Risk of disseminated infection; avoid live vaccines. |
| Anticoagulants | Moderate | Increased bleeding risk; monitor INR. |
๐จ Major Interactions
- Warfarin
- Phenytoin
- CYP1A2 inhibitors (e.g., fluvoxamine)
- CYP2E1 inhibitors (e.g., disulfiram)
โก Moderate Interactions
- Other myelosuppressive agents
- Live vaccines
- Anticoagulants
โน๏ธ Minor Interactions
- Corticosteroids
- Antiemetics
๐ฝ๏ธ Food Interactions
No significant food interactions; administered intravenously.
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to dacarbazine; severe myelosuppression; pregnancy.
๐ Monitoring Parameters
Complete blood count (CBC), liver function tests (LFTs), renal function tests, serum electrolytes.
๐คฑ Lactation Safety
Contraindicated; discontinue breastfeeding during therapy.
๐ Overdose Management
Supportive care; monitor for myelosuppression, hepatic toxicity; no specific antidote.
โฐ Missed Dose
Administer as soon as possible; do not double dose; consult physician.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cedcozine 1000mg injection
View AllAlternative brands with exact same active ingredient (Dacarbazine (1000mg)):
Medical Note: Always consult your doctor before switching medications.