cebate gm active cream - Clobetasol (0.05% w/v) + Miconazole (2% w/w/1gm) medicine

cebate gm active cream - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Sanofi India Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is cebate gm active cream used for?

Agmaderm Cream (Clobetasol + Miconazole) is used to treat DERMA. It contains Clobetasol (0.05% w/v) + Miconazole (2% w/w/1gm), which Clobetasol: Anti-inflammatory via glucocorticoid receptor; Miconazole: Inhibits . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Clobetasol + Miconazole
  • Manufacturer: Sanofi India Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š cebate gm active cream Uses & Benefits

Treatment of inflammatory dermatoses with fungal infection, e.g., tinea, candidiasis, eczema with secondary infection.

Off-label uses: Psoriasis, Lichen planus

๐Ÿ“‹ Drug Information

Generic Name(s)Clobetasol + Miconazole
Brand NameAgmaderm Cream
ManufacturerSanofi India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassCorticosteroid + Antifungal
Route of AdministrationTopical
StorageStore at 20-25ยฐC; avoid freezing.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionPercutaneous absorption varies; increased with inflamed skin or occlusion.
DistributionDistributes locally; systemic absorption minimal with intact skin.
Protein BindingClobetasol: 96-99%; Miconazole: ~90%
MetabolismClobetasol: Hepatic via CYP3A4; Miconazole: Hepatic extensively.
Half-LifeClobetasol: ~2-3 hours; Miconazole: ~20-24 hours.
ExcretionClobetasol: Renal and biliary; Miconazole: Feces (major) and urine.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days of regular application.
Peak Plasma TimeNot well defined for topical; systemic peak varies.
Duration of ActionSustained effect with twice-daily application.

How It Works

Clobetasol: Anti-inflammatory via glucocorticoid receptor; Miconazole: Inhibits ergosterol synthesis disrupting fungal cell membrane.

Mechanism Steps

1Clobetasol binds to glucocorticoid receptor, modulating gene expression to reduce inflammation.
2Miconazole inhibits lanosterol 14ฮฑ-demethylase, blocking ergosterol synthesis.
3Ergosterol depletion disrupts fungal cell membrane integrity, leading to cell death.

๐Ÿ’ก How to Take cebate gm active cream

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cebate gm active cream

โœ… Common Side Effects

  • Burning
  • Itching
  • Irritation
  • Dryness

๐Ÿšจ Serious Side Effects

  • Adrenal suppression
  • Cushing's syndrome
  • Skin atrophy
  • Allergic contact dermatitis

โš ๏ธ Rare Side Effects

  • Perioral dermatitis
  • Hypertrichosis
  • Hypopigmentation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Ketoconazole Major Increased systemic corticosteroid effects
Insulin Moderate May alter blood glucose levels

๐Ÿšจ Major Interactions

  • CYP3A4 inhibitors
  • Anticoagulants

โšก Moderate Interactions

  • Antidiabetic agents
  • Diuretics

โ„น๏ธ Minor Interactions

  • NSAIDs
  • Vaccines

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to components; untreated bacterial or viral infections; rosacea; perioral dermatitis.

๐Ÿ“Š Monitoring Parameters

Assess skin response; monitor for signs of systemic absorption (adrenal suppression) with prolonged use.

๐Ÿคฑ Lactation Safety

Use with caution; avoid application to breast area.

๐Ÿ’Š Overdose Management

Acute overdose unlikely; chronic overuse may cause systemic corticosteroid effects; treat symptomatically.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

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