Cartirise Tablet: Complete Guide To Uses, Dosage, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or persistent diarrhoea with dehydration
- Yellowing of the eyes or skin, or dark urine
- Severe abdominal pain radiating to the back
- Blood in vomit or black, tarry stools
- Swelling of the face, lips, or throat, or difficulty breathing
- Decreased urine output or swelling in the legs
- Unusual bruising or bleeding
- Severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is cartirise tablet used for?
This medicine is a prescription oral tablet combining diacerein 50 mg and glucosamine 750 mg. It is used to relieve pain and stiffness in osteoarthritis of the knee, hip, and hand. It works slowly, usually taking 2 to 4 weeks to show benefit, and should be taken with food to reduce stomach upset. It is not recommended during pregnancy, breastfeeding, or in severe liver or kidney disease.
- Generic Name: Diacerein + Glucosamine
- Manufacturer: Baryton Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cartirise tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से घुटने, कूल्हे और हाथ के ऑस्टियोआर्थराइटिस (जोड़ों की घिसावट) के इलाज के लिए इस्तेमाल की जाती है। यह जोड़ों के दर्द, अकड़न और सूजन को कम करने में मदद करती है और जोड़ों की गतिशीलता को बेहतर बनाती है। यह एक धीमी गति से काम करने वाली दवा है, इसलिए इसका असर दिखने में कुछ हफ्ते लग सकते हैं। इसे डॉक्टर की सलाह के अनुसार ही लें और खाने के साथ लें ताकि पेट की परेशानी कम हो।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट से जुड़े होते हैं, जैसे दस्त, पेट दर्द, मतली और एसिडिटी। कुछ लोगों को सिरदर्द या त्वचा पर चकत्ते भी हो सकते हैं। कभी-कभी यह दवा लीवर की समस्या पैदा कर सकती है, जिसके लक्षण हैं आंखों या त्वचा का पीला पड़ना, गहरे रंग का पेशाब और थकान। अगर आपको लगातार दस्त, पेट में तेज दर्द, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा खाने के साथ लें ताकि पेट में जलन या दस्त की समस्या कम हो। डॉक्टर द्वारा बताई गई मात्रा से ज्यादा कभी न लें। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट और लीवर पर बुरा असर पड़ सकता है। अगर आपको लीवर या किडनी की बीमारी है, या आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को जरूर बताएं। कोई भी नई दवा शुरू करने से पहले डॉक्टर या फार्मासिस्ट से सलाह लें। दवा को ठंडी और सूखी जगह पर, धूप से दूर, मूल पैकेट में ही रखें।
💊 cartirise tablet Uses & Benefits
[{"condition":"Knee osteoarthritis","description":"Reduces pain, improves joint function, and may slow cartilage degradation in mild to moderate knee osteoarthritis.","evidence":"Moderate"},{"condition":"Hip osteoarthritis","description":"Used to relieve pain and stiffness and to improve mobility in hip osteoarthritis.","evidence":"Moderate"},{"condition":"Hand osteoarthritis","description":"May help reduce pain and improve hand function in osteoarthritis of the fingers and thumb base.","evidence":"Limited"},{"condition":"General osteoarthritis with cartilage loss","description":"Prescribed as a slow-acting symptomatic treatment to support cartilage health and reduce long-term symptoms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Low back pain with degenerative changes","description":"Sometimes prescribed off-label for chronic low back pain associated with facet joint or disc degeneration.","evidence":"Limited"},{"condition":"Temporomandibular joint osteoarthritis","description":"Occasionally used off-label for jaw joint pain and dysfunction related to osteoarthritis.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Knee osteoarthritis, Hip osteoarthritis, Hand osteoarthritis, Degenerative joint disease
📋 Drug Information
| Generic Name(s) | Diacerein + Glucosamine |
| Brand Name | Arthocerin-DG Tablet |
| Manufacturer | Baryton Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | PAIN ANALGESICS |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place. Protect from moisture and direct sunlight. Keep the tablets in their original container with the lid tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. The World Health Organization does not have a specific recommendation for this fixed-dose combination. Guidelines generally recommend a stepwise approach to osteoarthritis management including exercise, weight management, and symptomatic slow-acting drugs in selected patients. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not published a specific recommendation for this fixed-dose combination. Indian guidelines for osteoarthritis generally include symptomatic slow-acting drugs as an option for symptom relief. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two agents with complementary actions. Diacerein is a slow-acting anti-inflammatory drug that inhibits the production and activity of interleukin-1 beta, a cytokine that promotes cartilage breakdown and joint inflammation. By blocking interleukin-1, diacerein reduces the expression of matrix metalloproteinases and other enzymes that degrade cartilage, and it may stimulate the synthesis of cartilage matrix components. Glucosamine is an amino sugar that serves as a substrate for the synthesis of glycosaminoglycans and proteoglycans, which are essential building blocks of cartilage. Glucosamine may also have mild anti-inflammatory effects and can reduce pain signaling in osteoarthritis. Together, these ingredients aim to relieve symptoms and support joint structure over time.
Mechanism Steps
💡 How to Take cartirise tablet
Strength: Each immediate-release oral tablet contains diacerein 50 mg and glucosamine 750 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily with meals, as prescribed by your doctor. The exact dose and duration depend on the severity of osteoarthritis, your response to treatment, and your kidney and liver function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. It may take several weeks to notice improvement. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children and adolescents below 18 years of age. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially diarrhoea and dehydration. The dose should be individualized by a clinician, and kidney and liver function should be monitored. Start with the lowest effective dose and adjust as needed. |
| Renal Impairment | This medicine is not recommended in patients with severe kidney disease. In mild to moderate kidney impairment, the dose may need to be reduced or the medicine avoided. Dose must be individualized by a qualified clinician based on renal function. Monitor kidney function regularly. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In mild to moderate liver impairment, use with caution and monitor liver function. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily, providing diacerein 100 mg and glucosamine 1500 mg per day. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cartirise tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Isoniazid | Major | |
| NSAIDs | Major | |
| Aminoglycosides | Major | |
| Insulin | Moderate | |
| Metformin | Moderate | |
| Furosemide | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Hepatotoxic drugs (e.g., methotrexate, isoniazid)
- Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides)
⚡ Moderate Interactions
- Antidiabetic drugs
- Diuretics
- Laxatives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach irritation, worsen diarrhoea, and add to liver stress, especially with long-term use. If you drink alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to diacerein, glucosamine, or any component of this medicine","Inflammatory bowel disease such as ulcerative colitis or Crohn's disease","Severe liver disease or active liver disease","Severe kidney disease or chronic kidney disease stage 4 or 5","Pregnancy and breastfeeding","Children and adolescents below 18 years of age","History of severe diarrhoea or malabsorption syndromes"]
⚠️ Warnings & Precautions
["This medicine can cause diarrhoea. Stop the medicine and consult your doctor if diarrhoea is severe or persistent.","Use with caution in elderly patients because they are more prone to dehydration and electrolyte imbalance.","Monitor liver function during long-term use, especially if you have risk factors for liver disease.","Monitor kidney function if you have diabetes, hypertension, or existing kidney problems.","Avoid alcohol while taking this medicine.","Do not take this medicine with other hepatotoxic or nephrotoxic drugs without medical advice.","Inform your doctor if you have diabetes, as glucosamine may affect blood sugar control.","This medicine is not recommended for children and adolescents.","Do not use this medicine for immediate relief of acute pain; it works slowly.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. It is not known whether diacerein or glucosamine pass into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause severe diarrhoea, dehydration, abdominal pain, and electrolyte imbalance. There is no specific antidote. Treatment is supportive and includes stopping the medicine, rehydration, and electrolyte replacement. Seek immediate medical attention if you suspect an overdose. Contact your local poison control center or emergency department for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine with food to reduce stomach upset. Swallow the tablet whole with a full glass of water; do not crush or chew it. Do not exceed the dose prescribed by your doctor. Avoid alcohol while taking this medicine because it can worsen stomach irritation and liver stress. Tell your doctor if you have a history of liver disease, kidney disease, inflammatory bowel disease, or stomach ulcers. Do not start any new medicine, including herbal products, without checking with your doctor or pharmacist. If you develop persistent diarrhoea, stop the medicine and contact your doctor. Keep all follow-up appointments so your doctor can monitor your liver and kidney function if needed. Store this medicine in its original container at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dehydration and electrolyte imbalance from diarrhoea caused by this medicine. They may also have reduced kidney and liver function, which can affect drug clearance. Use with caution, monitor kidney and liver function, and ensure adequate fluid intake. The dose may need to be adjusted by a clinician.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, discuss alternative treatments with your doctor. Do not start or stop this medicine without medical advice.
🏥 Post-Surgery Considerations
Not established from the available information. If you are scheduled for surgery, inform your surgeon and anesthesiologist about this medicine. It may need to be stopped before surgery depending on your overall health and the type of surgery. Follow your doctor's instructions.
🦷 Dental Procedures
Not established from the available information. Inform your dentist about this medicine before any dental procedure. There are no known specific interactions with dental anesthetics, but your dentist should be aware of all medicines you take.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue gentle exercises as advised by your doctor or physiotherapist. Avoid high-impact activities that strain your joints, such as running on hard surfaces or heavy weightlifting. If you experience increased pain or swelling after exercise, rest and consult your doctor. Stay hydrated during exercise, especially if you have diarrhoea.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness in some people, especially if you develop diarrhoea or dehydration. Avoid driving or operating heavy machinery if you feel unwell. Most people can continue their normal work routine, but take breaks and stay hydrated. Inform your employer if you need flexible hours during the initial weeks of treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe diarrhoea, signs of liver problems such as yellowing of eyes or dark urine, or any allergic reaction, stop the medicine and seek medical advice immediately. Your doctor may advise stopping the medicine if you do not experience benefit after an adequate trial or if monitoring shows liver or kidney problems.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver and kidney function. Some patients may experience persistent gastrointestinal symptoms such as diarrhoea. The benefits for osteoarthritis may continue with regular use, but the medicine should be reviewed periodically by your doctor to assess ongoing need and safety. Do not continue long-term without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Targeted exercises to strengthen muscles around the joint and improve flexibility.
Evidence: Well-establishedLosing excess weight reduces load on weight-bearing joints and improves symptoms.
Evidence: Well-establishedCreams or gels applied to the joint can provide local pain relief with fewer systemic side effects.
Evidence: Well-establishedInjections into the joint may provide temporary symptom relief in some patients.
Evidence: ModerateMay help reduce pain in some patients with osteoarthritis.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container with the lid tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription and a doctor's note if you are traveling internationally. Store it in your hand luggage to avoid temperature extremes in checked baggage. Keep it away from direct sunlight and moisture. If you are crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor if you are unsure about adjusting the schedule. Declare the medicine at customs if required by local regulations.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is slow-acting. It may take 2 to 4 weeks to notice improvement, and maximum benefit may take 6 to 8 weeks.
A: Yes, take it with a meal to reduce stomach upset and diarrhoea.
A: Common side effects include loose stools, diarrhoea, stomach pain, nausea, and heartburn. These are usually mild and may settle with continued use.
A: This medicine may affect kidney function in some people. It is not recommended in severe kidney disease. Your doctor may monitor your kidney function, especially if you have diabetes or hypertension.
A: This medicine is not recommended during pregnancy unless clearly needed and advised by a specialist. Discuss with your doctor if you are pregnant or planning pregnancy.
A: Avoid alcohol while taking this medicine because it can increase stomach irritation and liver stress.
A: If you remember within a few hours, take the missed dose. If it is almost time for the next dose, skip it and continue your regular schedule. Do not double dose.
A: Glucosamine may slightly increase blood sugar and reduce the effect of diabetes medicines. Monitor your blood glucose more frequently and inform your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for cartirise tablet
View AllAlternative brands with exact same active ingredient:
-
mericartrin 50mg/750mg tabletMerion Care ₹35.16 71.6% CHEAPER
-
gencos d 50mg/750mg tabletMedlife Genetics ₹39.00 68.5% CHEAPER
-
keyrin plus 50mg/750mg tabletKlokter Life Sciences ₹45.00 63.6% CHEAPER
-
natcos-d tabletNovogen Captab ₹56.25 54.5% CHEAPER
-
stayhappi glucosamine+diacerein+methyl sulfonyl methane 750mg/50mg/250mg tabletSarvagunaushdhi Pvt Ltd ₹65.63 47% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine gives instant pain relief.
Fact: This medicine is a slow-acting symptomatic treatment. It may take 2 to 4 weeks or longer to show noticeable benefit. - Myth: This medicine can cure osteoarthritis.
Fact: This medicine helps relieve symptoms and may support cartilage health, but it does not cure osteoarthritis. Lifestyle measures and other treatments are also important. - Myth: It is safe to take this medicine without a prescription.
Fact: This medicine is a prescription drug. It should only be taken under medical supervision because of potential liver, kidney, and gastrointestinal effects. - Myth: More tablets mean faster relief.
Fact: Taking more than the prescribed dose increases the risk of side effects and does not provide faster relief. - Myth: This medicine is safe for everyone.
Fact: This medicine is not suitable for people with severe liver or kidney disease, inflammatory bowel disease, or during pregnancy and breastfeeding.
🔄 Alternative Options
Generic Alternatives
- Diacerein 50 mg + Glucosamine 750 mg tablet
Brand Alternatives
- Cartirise Tablet