cardizest 12.5mg tablet - Carvedilol (12.5mg) medicine

cardizest 12.5mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Innovative Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is cardizest 12.5mg tablet used for?

Cardivas 3.125 Tablet (Carvedilol) is used to treat CARDIAC. It contains Carvedilol (12.5mg), which Blocks beta-1, beta-2, and alpha-1 adrenergic receptors, leading to vasodilation. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Carvedilol
  • Manufacturer: Innovative Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š cardizest 12.5mg tablet Uses & Benefits

Hypertension, chronic heart failure, left ventricular dysfunction after myocardial infarction.

Off-label uses: Migraine prophylaxis, angina, arrhythmias, portal hypertension.

๐Ÿ“‹ Drug Information

Generic Name(s)Carvedilol
Brand NameCardivas 3.125 Tablet
ManufacturerInnovative Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassAlpha & beta blocker
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations occur within 1-2 hours.
DistributionExtensively distributed into tissues; volume of distribution approximately 115 L.
Protein BindingApproximately 98% bound to plasma proteins (primarily albumin).
MetabolismExtensively metabolized in the liver via CYP2D6 and CYP2C9; undergoes glucuronidation and sulfation.
Half-Life7-10 hours
ExcretionPrimarily excreted in feces (60%) and urine (16%) as metabolites; less than 2% excreted unchanged.
BioavailabilityApproximately 25-35% due to first-pass metabolism.
Onset of Action1-2 hours
Peak Plasma Time1-2 hours
Duration of Action12-24 hours

How It Works

Blocks beta-1, beta-2, and alpha-1 adrenergic receptors, leading to vasodilation and reduced heart rate.

Mechanism Steps

1Carvedilol competitively blocks beta-1 adrenergic receptors in the heart, reducing heart rate and contractility.
2Blocks beta-2 adrenergic receptors in vascular smooth muscle, preventing vasodilation but also reducing bronchodilation.
3Blocks alpha-1 adrenergic receptors in vascular smooth muscle, causing vasodilation and reducing peripheral vascular resistance.

๐Ÿ’ก How to Take cardizest 12.5mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cardizest 12.5mg tablet

โœ… Common Side Effects

  • Dizziness
  • Fatigue
  • Hypotension
  • Bradycardia
  • Diarrhea
  • Nausea
  • Weight gain

๐Ÿšจ Serious Side Effects

  • Heart block
  • Severe bradycardia
  • Bronchospasm
  • Hepatic injury
  • Peripheral ischemia

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Anaphylaxis
  • Thrombocytopenia
  • Alopecia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Verapamil Major Increased risk of bradycardia and heart block
Digoxin Major Increased digoxin levels and risk of toxicity
Insulin Major Enhanced hypoglycemic effect; may mask tachycardia

๐Ÿšจ Major Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP2C9 inhibitors (e.g., amiodarone)
  • Calcium channel blockers (e.g., verapamil, diltiazem)
  • Digoxin
  • Clonidine
  • Insulin and oral hypoglycemics

โšก Moderate Interactions

  • NSAIDs
  • Rifampin
  • Barbiturates
  • Cimetidine

โ„น๏ธ Minor Interactions

  • Antacids
  • Grapefruit juice

๐Ÿฝ๏ธ Food Interactions

Food delays absorption but does not affect bioavailability; take with food to reduce orthostatic hypotension.

๐Ÿท Alcohol Interaction

Alcohol may enhance hypotensive effects; avoid excessive alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Bronchial asthma, severe bradycardia, heart block (2nd or 3rd degree), cardiogenic shock, decompensated heart failure, severe hepatic impairment.

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, ECG, blood glucose (in diabetics), renal function, hepatic function.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Supportive care; administer atropine for bradycardia, glucagon for myocardial depression, and vasopressors for hypotension.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for cardizest 12.5mg tablet

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Alternative brands with exact same active ingredient (Carvedilol (12.5mg)):

Medical Note: Always consult your doctor before switching medications.

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