candirap cream

4.6 (15 reviews)

Itraconazole (1% w/w)

🏭 Rapross Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is candirap cream used for?

Alcros 100 Capsule (Itraconazole) is used to treat OPHTHAL. It contains Itraconazole (1% w/w), which Inhibits fungal cytochrome P450 14α-demethylase, blocking ergosterol synthesis . Always consult your doctor before use. Take as prescribed.

Generic Name: Itraconazole
Manufacturer: Rapross Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 candirap cream Uses & Benefits

Onychomycosis, dermatophytosis, candidiasis, histoplasmosis, blastomycosis, aspergillosis.

Off-label uses: Coccidioidomycosis, sporotrichosis, chromoblastomycosis, prophylaxis in immunocompromised patients.

📋 Drug Information

Generic Name(s)	Itraconazole
Brand Name	Alcros 100 Capsule
Manufacturer	Rapross Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	OPHTHAL
Action Class	Fungal ergosterol synthesis inhibitor
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; absorption is enhanced when taken with food.

DistributionWidely distributed in body tissues, including skin, nails, and adipose tissue.

Protein Binding99.8% bound to plasma proteins, primarily albumin.

MetabolismExtensively metabolized in the liver via CYP3A4 to active metabolite hydroxyitraconazole.

Half-Life21-25 hours (itraconazole); 12-15 hours (hydroxyitraconazole)

ExcretionPrimarily excreted in feces (40%) and urine (35%) as metabolites.

BioavailabilityApproximately 55% (fasting); increased to 100% with food.

Onset of Action1-2 weeks for therapeutic effect in fungal infections.

Peak Plasma Time4-6 hours after oral administration.

Duration of ActionUp to 2-3 weeks after discontinuation due to tissue accumulation.

How It Works

Inhibits fungal cytochrome P450 14α-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.

Mechanism Steps

1Itraconazole enters fungal cell via diffusion.

2Binds to heme iron of fungal CYP450 14α-demethylase.

3Inhibits conversion of lanosterol to ergosterol.

💡 How to Take candirap cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of candirap cream

✅ Common Side Effects

Nausea
Abdominal pain
Diarrhea
Headache
Dizziness
Rash

🚨 Serious Side Effects

Hepatotoxicity
Congestive heart failure
QT prolongation
Torsades de pointes
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Peripheral neuropathy
Adrenal suppression
Hypokalemia
Gynecomastia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Moderate	Increased INR and bleeding risk
Simvastatin	Major	Increased risk of rhabdomyolysis
Midazolam	Major	Prolonged sedation and respiratory depression

🚨 Major Interactions

CYP3A4 substrates (e.g., midazolam, triazolam)
HMG-CoA reductase inhibitors (e.g., simvastatin, lovastatin)
Ergot alkaloids
Cisapride
Pimozide
Quinidine
Dofetilide
Lovastatin
Simvastatin

⚡ Moderate Interactions

Warfarin
Oral hypoglycemics
Calcium channel blockers
Digoxin
Cyclosporine
Tacrolimus
Sirolimus
Carbamazepine
Phenytoin
Rifampin
Isoniazid
Antacids
H2 blockers
Proton pump inhibitors

ℹ️ Minor Interactions

Corticosteroids
Benzodiazepines (e.g., alprazolam)
Oral contraceptives

🍽️ Food Interactions

Absorption increased with acidic beverages (e.g., cola) and food; avoid grapefruit juice.

🍷 Alcohol Interaction

Avoid alcohol due to potential hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to itraconazole or excipients; concomitant use with CYP3A4 substrates with narrow therapeutic index; ventricular dysfunction; pregnancy (category C).

📊 Monitoring Parameters

Liver function tests (ALT, AST), serum potassium, ECG (QT interval), therapeutic drug monitoring if needed.

🤱 Lactation Safety

Excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; no specific antidote; gastric lavage if recent; monitor liver function and ECG.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for candirap cream

View All

Alternative brands with exact same active ingredient (Itraconazole (1% w/w)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

candirap cream

What is candirap cream used for?

💊 candirap cream Uses & Benefits

📋 Drug Information

🔬 Pharmacology (PK/PD)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take candirap cream

⚠️ Side Effects of candirap cream

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

ℹ️ Minor Interactions

🍽️ Food Interactions

🍷 Alcohol Interaction

🛡️ Safety & Warnings

🚫 Contraindications

📊 Monitoring Parameters

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

🔄 Substitutes for candirap cream

⭐ User Reviews

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