afitra-l cream - Luliconazole (1% w/w) medicine

afitra-l cream - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Rapross Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is afitra-l cream used for?

Azole 1% Cream (Luliconazole) is used to treat DERMA. It contains Luliconazole (1% w/w), which Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Luliconazole
  • Manufacturer: Rapross Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š afitra-l cream Uses & Benefits

Tinea pedis, tinea cruris, tinea corporis, candidiasis, pityriasis versicolor

Off-label uses: Onychomycosis, Seborrheic dermatitis

๐Ÿ“‹ Drug Information

Generic Name(s)Luliconazole
Brand NameAzole 1% Cream
ManufacturerRapross Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationTopical
StorageStore at 20-25ยฐC (68-77ยฐF); protect from freezing
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption; primarily local action
DistributionLimited systemic distribution; high concentration in stratum corneum
Protein Binding>99% bound to plasma proteins
MetabolismHepatic via CYP450 enzymes (CYP3A4, CYP2C9, CYP2C19)
Half-LifeNot clinically relevant due to topical use; systemic half-life ~130 hours
ExcretionFeces (major) and urine (minor)
BioavailabilityNegligible systemic bioavailability (<1%)
Onset of ActionWithin 24-48 hours
Peak Plasma TimeNot applicable (topical)
Duration of ActionUp to 24 hours after single application

How It Works

Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis

Mechanism Steps

1Inhibition of fungal CYP450 14ฮฑ-demethylase
2Blockade of lanosterol conversion to ergosterol
3Accumulation of toxic methylated sterols

๐Ÿ’ก How to Take afitra-l cream

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of afitra-l cream

โœ… Common Side Effects

  • Application site irritation
  • Pruritus
  • Burning
  • Erythema

๐Ÿšจ Serious Side Effects

  • Hypersensitivity reactions
  • Contact dermatitis

โš ๏ธ Rare Side Effects

  • Blistering
  • Edema
  • Urticaria

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased INR and bleeding risk
CYP3A4 substrates Major Potential for increased systemic levels of co-administered drugs
CYP2C9 substrates Major Potential for increased systemic levels of co-administered drugs

๐Ÿšจ Major Interactions

  • Warfarin
  • CYP3A4 substrates
  • CYP2C9 substrates

โšก Moderate Interactions

  • Oral contraceptives
  • Anticoagulants

โ„น๏ธ Minor Interactions

  • Antacids
  • H2 antagonists

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to luliconazole or any excipients

๐Ÿ“Š Monitoring Parameters

Clinical improvement; signs of irritation or hypersensitivity

๐Ÿคฑ Lactation Safety

Not recommended; unknown if excreted in milk

๐Ÿ’Š Overdose Management

Not expected with topical use; if ingested, symptomatic treatment

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for afitra-l cream

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Alternative brands with exact same active ingredient (Luliconazole (1% w/w)):

Medical Note: Always consult your doctor before switching medications.

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