candifin f lotion - Terbinafine (1% w/v) + Fluticasone Propionate (0.05% w/v) medicine

candifin f lotion

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🏭 Eumedia Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is candifin f lotion used for?

This medicine contains Terbinafine (1% w/v) + Fluticasone Propionate (0.05% w/v) and is used to treat DERMA. Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Fluticasone binds to gluco. Always consult your doctor before use.

  • Generic Name: Terbinafine + Fluticasone Propionate
  • Manufacturer: Eumedia Pharma
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 candifin f lotion Uses & Benefits

Topical treatment of fungal infections with inflammation, e.g., tinea cruris, tinea corporis, tinea pedis.

Off-label uses: Tinea versicolor, cutaneous candidiasis (with caution).

📋 Drug Information

Generic Name(s)Terbinafine + Fluticasone Propionate
Brand NameCandifin F Lotion
ManufacturerEumedia Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntifungal + Corticosteroid
Route of AdministrationTopical
StorageStore at room temperature (15-30°C); keep tightly closed; avoid freezing.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low.
DistributionDistributes locally in skin layers; minimal systemic distribution.
Protein BindingTerbinafine: >99% bound to plasma proteins; Fluticasone: ~91% bound.
MetabolismTerbinafine: extensively metabolized in liver via CYP450; Fluticasone: metabolized in liver via CYP3A4.
Half-LifeTerbinafine: 11-17 hours; Fluticasone: 7.8 hours.
ExcretionTerbinafine: 70% urine; Fluticasone: primarily feces.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days of regular application.
Peak Plasma TimeNot applicable for topical use; minimal systemic absorption.
Duration of ActionOnce daily application maintains effect.

How It Works

Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Fluticasone binds to glucocorticoid receptors, suppressing inflammation.

Mechanism Steps

1Terbinafine inhibits squalene epoxidase, blocking conversion of squalene to lanosterol
2Accumulation of squalene and deficiency of ergosterol disrupts fungal cell membrane
3Fluticasone binds to glucocorticoid receptor, leading to inhibition of phospholipase A2
4Reduced release of arachidonic acid and inflammatory mediators
5Suppression of vasodilation, edema, and immune response

💡 How to Take candifin f lotion

Follow your doctor's prescription exactly.

⚠️ Side Effects of candifin f lotion

✅ Common Side Effects

Application site irritation
burning
itching
dryness

🚨 Serious Side Effects

Skin atrophy
striae
telangiectasia
allergic contact dermatitis

⚠️ Rare Side Effects

Systemic effects of corticosteroid (prolonged use on large areas)
hepatotoxicity (very rare with topical)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CYP3A4 inhibitors (e.g., ketoconazole) Major Increased systemic exposure to fluticasone
CYP3A4 inducers (e.g., rifampin) Major Decreased fluticasone efficacy

🚨 Major Interactions

  • CYP3A4 inhibitors
  • CYP3A4 inducers

⚡ Moderate Interactions

  • Anticoagulants
  • Antidiabetic agents

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component; viral, fungal (without antifungal), or bacterial skin infections; rosacea; perioral dermatitis.

🤱 Lactation Safety

Caution; minimal systemic absorption, but avoid application to breast area.

💊 Overdose Management

Unlikely with topical use; if ingested, symptomatic treatment.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose; do not double.

🔄 Substitutes for candifin f lotion

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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