calcobal plus injection - Uses, Price, Side Effects & Substitutes
What is calcobal plus injection used for?
Alnacob Plus Injection (Methylcobalamin + Vitamin B6 (Pyridoxine)) is used to treat VITAMINS MINERALS NUTRIENTS. It contains Methylcobalamin (1000mcg) + Vitamin B6 (Pyridoxine) (100mg), which Methylcobalamin acts as a cofactor for methionine synthase, essential for myelin. Always consult your doctor before use. Take as prescribed.
- Generic Name: Methylcobalamin + Vitamin B6 (Pyridoxine)
- Manufacturer: Clarix Healthcare
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ calcobal plus injection Uses & Benefits
Peripheral neuropathy, megaloblastic anemia, homocysteinemia, vitamin B12 and B6 deficiency.
Off-label uses: Chronic fatigue syndrome, diabetic neuropathy, carpal tunnel syndrome.
๐ Drug Information
| Generic Name(s) | Methylcobalamin + Vitamin B6 (Pyridoxine) |
| Brand Name | Alnacob Plus Injection |
| Manufacturer | Clarix Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Vitamins/Minerals/Nutrients |
| Route of Administration | Intramuscular injection |
| Storage | Store at 2-8ยฐC, protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Methylcobalamin acts as a cofactor for methionine synthase, essential for myelin synthesis; Pyridoxine is a cofactor for enzymes in neurotransmitter synthesis and homocysteine metabolism.
Mechanism Steps
๐ก How to Take calcobal plus injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of calcobal plus injection
โ Common Side Effects
- Injection site pain
- Mild diarrhea
- Headache
๐จ Serious Side Effects
- Anaphylaxis
- Peripheral neuropathy (with high dose pyridoxine)
- Thrombotic events
โ ๏ธ Rare Side Effects
- Acne
- Photosensitivity
- Hypersensitivity reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Levodopa | Major | Pyridoxine reduces levodopa efficacy by increasing peripheral metabolism. |
| Chloramphenicol | Major | May impair response to vitamin B12 therapy. |
| Colchicine | Major | May decrease absorption of vitamin B12. |
| Phenytoin | Moderate | Pyridoxine may decrease phenytoin levels. |
| Oral contraceptives | Moderate | May increase requirement for pyridoxine. |
| Isoniazid | Moderate | May cause pyridoxine deficiency. |
| Penicillamine | Minor | May increase pyridoxine requirement. |
| Cycloserine | Minor | May increase pyridoxine requirement. |
๐จ Major Interactions
- Levodopa
- Chloramphenicol
- Colchicine
โก Moderate Interactions
- Anticonvulsants (phenytoin, phenobarbital)
- Oral contraceptives
- Isoniazid
โน๏ธ Minor Interactions
- Penicillamine
- Cycloserine
๐ฝ๏ธ Food Interactions
None significant
๐ท Alcohol Interaction
Chronic alcohol use may reduce absorption of vitamin B6.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; severe renal impairment (for high doses of pyridoxine).
๐ Monitoring Parameters
Serum vitamin B12 and B6 levels, homocysteine levels, neurological examination.
๐คฑ Lactation Safety
Safe; both vitamins are excreted in breast milk but not harmful.
๐ Overdose Management
Discontinue injection; symptomatic treatment; pyridoxine overdose may cause neuropathy.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose.