cadcof tr syrup - Bromhexine (2mg/5ml) + Guaifenesin (50mg/5ml) medicine

Ascoril Plus Expectorant: Complete Medicine Guide

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🏭 Caddes Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
🤰 Pregnancy Category Not established from the available information. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for symptomatic relief of productive cough.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in sputum or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is cadcof tr syrup used for?

This medicine is an expectorant combination of bromhexine and guaifenesin used to treat productive cough with thick mucus. It works by thinning mucus and making it easier to cough out. It is not for dry cough.

  • Generic Name: Bromhexine + Guaifenesin
  • Manufacturer: Caddes Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cadcof tr syrup के बारे में (Hindi Summary)

उपयोग: यह दवा ब्रोमहेक्सिन और गुआइफेनेसिन का संयोजन है, जिसका उपयोग गाढ़े बलगम वाली खांसी के इलाज के लिए किया जाता है। यह बलगम को पतला करके उसे बाहर निकालने में मदद करती है। यह सूखी खांसी के लिए नहीं है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में असुविधा और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। दवा लेते समय भरपूर पानी पिएं। सूखी खांसी के लिए इसका इस्तेमाल न करें। यदि आपको पेट अल्सर, लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। गर्भवती और स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 cadcof tr syrup Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps loosen and thin mucus in the airways, making it easier to cough out.","evidence":"Well-established"},{"condition":"Acute bronchitis","description":"Used as a supportive treatment to relieve cough and mucus congestion.","evidence":"Moderate"},{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus hypersecretion","description":"May help in clearing mucus and improving symptoms, but not a primary treatment.","evidence":"Limited"}]

Off-label uses: [{"condition":"Sinusitis with thick nasal discharge","description":"Sometimes used off-label to thin nasal secretions, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Productive cough with thick mucus

Also treats: Acute bronchitis, Chronic obstructive pulmonary disease (COPD) with mucus hypersecretion

📋 Drug Information

Generic Name(s)Bromhexine + Guaifenesin
Brand NameAscoril Plus Expectorant
ManufacturerCaddes Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. Do not refrigerate unless specified on the label.
Shelf Life24 months from the date of manufacture, or as indicated on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Drink plenty of water throughout the day to help loosen mucus.
3
Do not use this medicine for dry cough; it is only for productive cough.
4
Avoid alcohol while taking this medicine as it may increase drowsiness.
5
Do not take more than the prescribed dose.
6
Consult your doctor if symptoms persist beyond 7 days.
7
Report any unusual bleeding or bruising immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
Dry cough
This medicine is not for dry cough.
Not Primary
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBromhexine is rapidly absorbed from the gastrointestinal tract after oral administration. Guaifenesin is also absorbed from the gastrointestinal tract. The presence of food may slightly delay absorption but does not significantly affect the overall effect.
DistributionBromhexine is widely distributed in body tissues, including the lungs, and crosses the blood-brain barrier to a small extent. Guaifenesin is distributed throughout body fluids and tissues. Protein binding information for both agents is not well established.
Protein BindingNot established from the available information.
MetabolismBromhexine undergoes extensive first-pass metabolism in the liver, primarily by cytochrome P450 enzymes, to active metabolites. Guaifenesin is metabolized in the liver, but the exact pathways are not fully characterized.
Half-LifeThe elimination half-life of bromhexine is approximately 1-2 hours, while that of guaifenesin is about 1 hour. However, these values may vary.
ExcretionBromhexine and its metabolites are mainly excreted in the urine. Guaifenesin is also excreted in the urine, primarily as metabolites.
BioavailabilityThe oral bioavailability of bromhexine is low due to first-pass metabolism, approximately 20-30%. The bioavailability of guaifenesin is not well established but is thought to be around 50%.
Onset of ActionThe onset of action for bromhexine is typically within 30 minutes to 1 hour after oral administration. Guaifenesin may take a similar time to start working.
Peak Plasma TimePeak plasma concentrations of bromhexine are reached about 1 hour after oral administration. For guaifenesin, peak levels occur within 15-30 minutes.
Duration of ActionThe effects of this medicine last for approximately 4-6 hours, and it is usually taken 3 times a day.

How It Works

This medicine combines two active ingredients with complementary actions. Bromhexine works by breaking down the acidic mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to clear. It also stimulates the production of serous fluid in the respiratory tract, which further helps to thin secretions. Guaifenesin increases the volume and reduces the viscosity of respiratory tract secretions by increasing the water content of mucus, thereby promoting a more productive cough. Together, they enhance mucociliary clearance and make coughing more effective.

Mechanism Steps

1
Bromhexine breaks down mucus fibers: Bromhexine disrupts the structure of mucopolysaccharide fibers in mucus, reducing its thickness and stickiness.
2
Guaifenesin increases mucus water content: Guaifenesin draws water into the mucus, making it less viscous and easier to cough out.
3
Enhanced mucociliary clearance: The combined effect stimulates the cilia in the airways to move mucus more effectively towards the throat for expulsion.

💡 How to Take cadcof tr syrup

Strength: Each 5 ml contains Bromhexine 2 mg and Guaifenesin 50 mg.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the exact dose.
3Take the medicine orally, with or without food.
4Drink a glass of water after taking the medicine to help loosen mucus.
5Wash the measuring cup after each use.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 ml (2 teaspoons) three times a day, or as prescribed by your doctor. The dose may vary depending on the severity of the condition and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult a doctor for appropriate dosing.
Renal ImpairmentIn patients with severe renal impairment, the dose may need to be reduced. Consult a doctor for appropriate dosing.
Hepatic ImpairmentIn patients with severe hepatic impairment, the dose may need to be reduced. Consult a doctor for appropriate dosing.
Maximum Daily DoseThe maximum daily dose for adults is generally 30 ml (6 teaspoons) per day, but this may vary. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
No known interaction
No significant interaction reported.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cadcof tr syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated and avoid heavy meals. Consult doctor if vomiting continues.
Diarrhea (Common (5-10%))
Drink plenty of fluids. If diarrhea is severe or persistent, seek medical advice.
Stomach discomfort (Common (5-10%))
Take with food. If pain is severe, consult your doctor.
Headache (Uncommon (1-5%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop the medicine and seek immediate medical attention if you develop painful rash, blistering, or peeling skin.

⚠️ Rare Side Effects

Dizziness
Avoid driving or operating machinery until you feel normal. Consult doctor if it persists.
Drowsiness
Avoid activities requiring alertness. Consult doctor if it interferes with daily life.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Dextromethorphan Major
Amoxicillin Moderate
Tetracycline Moderate
Atropine Moderate
Furosemide Minor

🚨 Major Interactions

  • Cough suppressants (e.g., codeine, dextromethorphan)

⚡ Moderate Interactions

  • Antibiotics (e.g., amoxicillin, tetracycline)
  • Anticholinergic drugs (e.g., atropine)

🍷 Alcohol Interaction

Alcohol may increase the risk of drowsiness and dizziness when taken with this medicine. It is advisable to avoid alcohol while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to bromhexine, guaifenesin, or any component of the formulation.","Children under the age of 2 years (unless specifically prescribed by a pediatrician).","Peptic ulcer disease (relative contraindication; use with caution)."]

⚠️ Warnings & Precautions

["Do not use for dry, non-productive cough.","Do not exceed the recommended dose.","Consult a doctor if cough persists for more than 7 days, or if it is accompanied by fever, rash, or persistent headache.","Use with caution in patients with liver or kidney impairment.","Use with caution in patients with peptic ulcer disease.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Pregnant and breastfeeding women should consult a doctor before use."]

🤱 Lactation Safety

It is not known whether bromhexine and guaifenesin pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose with this medicine may cause nausea, vomiting, diarrhea, and abdominal discomfort. In severe cases, it may lead to drowsiness or dizziness. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Drink plenty of water while taking this medicine to help loosen mucus. Avoid taking this medicine for a dry cough or for more than 7 days without medical advice. If you have a history of stomach ulcers, liver disease, or kidney disease, inform your doctor before use. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. Pregnant and breastfeeding women should consult a doctor before using this medicine. Keep this medicine out of reach of children. Do not use this medicine after the expiry date. If symptoms persist or worsen, or if you develop fever, rash, or difficulty breathing, stop the medicine and seek medical attention immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and drowsiness. Dose adjustment may be needed based on liver and kidney function. Consult a doctor.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is not known if this medicine affects fertility.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you are taking other medications or have underlying conditions.

🦷 Dental Procedures

No specific precautions. However, inform your dentist if you are taking this medicine.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to add moisture to the air.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Practice good hand hygiene to prevent infections.

🏋️ Exercise Considerations

If you experience dizziness or drowsiness after taking this medicine, avoid strenuous exercise or activities requiring alertness. Otherwise, light exercise like walking may be beneficial.

🥗 Diet Recommendations

Drink warm fluids like herbal tea or soup.
Include honey and ginger in your diet.
Avoid cold and processed foods.
Eat plenty of fruits and vegetables rich in vitamin C.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery. Otherwise, it should not significantly impact your daily activities.

🛑 When to Stop This Medicine

Stop taking this medicine and consult a doctor if your cough persists for more than 7 days, or if you develop fever, rash, or difficulty breathing. Do not stop abruptly if you are on a prescribed course without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may mask underlying conditions such as chronic bronchitis or pneumonia. If symptoms persist beyond 7 days, consult a doctor. There is no known serious long-term toxicity with therapeutic doses, but regular monitoring of liver and kidney function may be advised in patients with pre-existing impairment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Can help loosen mucus and relieve congestion.

Evidence: Well-established
Saline nasal irrigation

Helps clear nasal passages and reduce postnasal drip.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you are due for a vaccine, inform your doctor about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with the prescription label. Keep a copy of your prescription with you. Store at room temperature and avoid extreme heat or cold. If traveling across time zones, continue with your regular dosing schedule as close as possible. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute bronchitis
Started this medicine as prescribed for productive cough with thick mucus. Within 2 days noticed significant improvement in cough and mucus clearance. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old with COPD and mucus hypersecretion
Used this medicine as an adjunct to COPD therapy. Found it helpful in clearing mucus, but experienced mild nausea initially. Taking it with meals reduced the nausea.
💡 Lesson: Taking the medicine with food can minimize gastrointestinal side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 minutes to 1 hour after taking a dose. You may notice loosening of mucus and easier coughing.

Q: Can I take this medicine with antibiotics?

A: Yes, but inform your doctor. Bromhexine may increase the penetration of antibiotics into respiratory secretions, which can be beneficial. However, always consult your doctor before combining.

Q: Is this medicine safe for children?

A: Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for cadcof tr syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with thick mucus. It is not effective for dry cough or cough due to allergies.
  • Myth: It is safe to take this medicine for a long time without doctor's advice.
    Fact: This medicine should not be used for more than 7 days without consulting a doctor. Prolonged use may mask underlying conditions.

🔄 Alternative Options

Generic Alternatives

  • Bromhexine + Guaifenesin oral liquid

Brand Alternatives

  • Ascoril Plus Expectorant

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Bromhexine 2mg/5ml + Guaifenesin 50mg/5ml","primary_use":"Productive cough","notes":"Combination expectorant"},{"medicine":"Ambroxol + Guaifenesin","composition":"Ambroxol + Guaifenesin","primary_use":"Productive cough","notes":"Similar mucolytic and expectorant"},{"medicine":"Guaifenesin alone","composition":"Guaifenesin","primary_use":"Productive cough","notes":"Expectorant only"}]

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