c dime 1000 mg/1000 mg injection - Cefoperazone (1000mg) + Sulbactam (1000mg) medicine

Assertum 1000 mg/1000 mg Injection: Complete Medicine Guide

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🏭 Emcure Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for susceptible bacterial infections.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of the face, lips, or throat
  • Severe or bloody diarrhoea
  • Unusual bleeding or bruising
  • Yellowing of the eyes or skin
  • Decreased urine output
  • Seizures or confusion
  • Severe skin rash with blisters or peeling

If experiencing severe symptoms, call emergency services immediately.

What is c dime 1000 mg/1000 mg injection used for?

This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given intravenously by a healthcare professional.

  • Generic Name: Cefoperazone + Sulbactam
  • Manufacturer: Emcure Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 c dime 1000 mg/1000 mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा सेफोपेराज़ोन और सल्बैक्टम का संयोजन है, जिसे नस के माध्यम से दिया जाता है। यह गंभीर जीवाणु संक्रमणों जैसे निमोनिया, मूत्र मार्ग संक्रमण, त्वचा संक्रमण, पेट के अंदर के संक्रमण और रक्त संक्रमण के इलाज के लिए अस्पताल में उपयोग की जाती है। यह दवा बैक्टीरिया को मारती है और संक्रमण को फैलने से रोकती है। यह केवल डॉक्टर की देखरेख में ही दी जानी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, चकत्ते, खुजली और इंजेक्शन लगाने की जगह पर दर्द शामिल हैं। कुछ रोगियों में लीवर एंजाइम बढ़ सकते हैं या खून की जांच में बदलाव दिख सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर दस्त, रक्तस्राव या त्वचा पर गंभीर प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। यदि आपको किडनी या लीवर की समस्या है या आप खून पतला करने वाली दवाएं ले रहे हैं, तो डॉक्टर को जरूर बताएं। इलाज के दौरान शराब न पिएं। बिना डॉक्टर की सलाह के इलाज बीच में न छोड़ें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 c dime 1000 mg/1000 mg injection Uses & Benefits

[{"condition":"Lower respiratory tract infections","description":"Used to treat pneumonia and bronchitis caused by susceptible bacteria when oral therapy is not appropriate.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated urinary tract infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for peritonitis and intra-abdominal abscesses.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Used in hospital settings for severe pelvic infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Septicaemia","description":"Used for bloodstream infections caused by susceptible Gram-negative and Gram-positive bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used for bacterial meningitis caused by susceptible organisms, though other agents are often preferred.","evidence":"Limited"}]

Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as part of empirical therapy in cancer patients with fever and low white blood cell counts.","evidence":"Limited"},{"condition":"Surgical prophylaxis","description":"Occasionally used before certain abdominal or pelvic surgeries to prevent infection.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Septicaemia

📋 Drug Information

Generic Name(s)Cefoperazone + Sulbactam
Brand NameAcuzone S 1000mg/500mg Injection
ManufacturerEmcure Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporin + Beta-lactamase inhibitor
Route of AdministrationIntravenous (IV) infusion or injection
StorageStore the unreconstituted powder at room temperature between 15°C and 30°C, protected from light and moisture. After reconstitution, use immediately or store as directed by the manufacturer. Do not freeze.
Shelf LifeTypically 24 to 36 months from the date of manufacture for the unreconstituted powder. Refer to the product label for the exact expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always reconstitute and administer this medicine under strict aseptic conditions.
2
Monitor renal and hepatic function regularly during therapy.
3
Watch for signs of bleeding, especially in patients on anticoagulants.
4
Assess for history of beta-lactam allergy before the first dose.
5
Consider local resistance patterns when choosing empirical therapy.
6
Educate nursing staff to report any infusion-related reactions promptly.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Fever with chills
This medicine is used for serious bacterial infections that can cause fever.
Likely Use
Cough with yellow or green sputum
This medicine may be prescribed for bacterial pneumonia.
Likely Use
Burning during urination
This medicine is used for complicated urinary tract infections.
Likely Use
Runny nose and sneezing
This medicine is not effective against viral infections like the common cold.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is given intravenously, so absorption from the gastrointestinal tract does not apply. After intravenous administration, cefoperazone and sulbactam are rapidly and completely available in the bloodstream.
DistributionCefoperazone distributes widely into body tissues and fluids, including bile, urine, sputum, and peritoneal fluid. Sulbactam also distributes into many tissues, but its penetration into cerebrospinal fluid is limited unless the meninges are inflamed.
Protein BindingCefoperazone is approximately 90% bound to plasma proteins. Sulbactam is approximately 38% bound to plasma proteins.
MetabolismCefoperazone is primarily excreted unchanged and is not extensively metabolised. Sulbactam is also largely excreted unchanged, with a small portion metabolised in the liver.
Half-LifeThe elimination half-life of cefoperazone is approximately 1.5 to 2.5 hours in healthy adults. The elimination half-life of sulbactam is approximately 1 hour.
ExcretionCefoperazone is excreted mainly in bile, with a smaller amount excreted in urine. Sulbactam is excreted primarily unchanged in urine.
BioavailabilityBioavailability is 100% when administered intravenously.
Onset of ActionThe antibacterial effect begins shortly after intravenous administration, with peak plasma concentrations reached at the end of the infusion.
Peak Plasma TimePeak plasma concentrations occur immediately at the end of an intravenous infusion.
Duration of ActionThe antibacterial effect typically lasts for about 12 hours after a standard intravenous dose, depending on the dose and the susceptibility of the organism.

How It Works

This medicine works by combining two complementary actions. Cefoperazone, a third-generation cephalosporin, binds to penicillin-binding proteins on the bacterial cell wall and blocks the final step of peptidoglycan cross-linking, which weakens the cell wall and leads to bacterial death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, preventing them from destroying cefoperazone. Together, they extend the antibacterial spectrum of cefoperazone to include many beta-lactamase-producing organisms.

Mechanism Steps

1
Cefoperazone binds to penicillin-binding proteins: Cefoperazone attaches to specific penicillin-binding proteins on the bacterial cell membrane, which are enzymes involved in building the cell wall.
2
Inhibition of cell wall cross-linking: By binding to these proteins, cefoperazone prevents the cross-linking of peptidoglycan strands, making the bacterial cell wall weak and unstable.
3
Sulbactam inhibits beta-lactamase enzymes: Sulbactam binds irreversibly to beta-lactamase enzymes produced by certain bacteria, preventing them from breaking down cefoperazone.
4
Bacterial cell lysis and death: With the cell wall compromised and cefoperazone protected, the bacterial cell takes in water, bursts, and dies.

💡 How to Take c dime 1000 mg/1000 mg injection

Strength: Each vial contains cefoperazone sodium equivalent to 1000 mg of cefoperazone and sulbactam sodium equivalent to 1000 mg of sulbactam.

1This medicine is given by a healthcare professional as an intravenous infusion or injection.
2The powder is reconstituted with sterile water for injection or another suitable diluent as directed by the manufacturer.
3The reconstituted solution is then further diluted and infused slowly over 30 to 60 minutes, or given as a slow intravenous injection over 3 to 5 minutes.
4Do not self-administer this medicine at home.
5Follow your healthcare provider's instructions regarding the duration of treatment.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 1 g to 2 g of cefoperazone combined with 1 g to 2 g of sulbactam given intravenously every 12 hours, depending on the severity and type of infection. For severe infections, the dose may be increased to every 8 hours. The maximum recommended daily dose is 8 g of cefoperazone. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may have reduced kidney function and may require lower doses. Dose must be individualized by a qualified clinician based on renal function and clinical response.
Renal ImpairmentIn patients with a creatinine clearance below 30 mL/min, dose adjustment is required. The dose may need to be reduced or the dosing interval extended. Consult a qualified clinician for individualized dosing.
Hepatic ImpairmentIn patients with severe liver disease or biliary obstruction, dose adjustment may be necessary. Monitor liver function and clinical response. Consult a qualified clinician for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 8 g of cefoperazone per day. Doses above this are not recommended.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Alcohol
Avoid
May increase the risk of side effects such as nausea, vomiting, and disulfiram-like reactions.

⏰ What to Do If You Miss a Dose

📌 You miss a scheduled dose in the hospital
→ Inform your nurse or doctor immediately.
💡 They will adjust the schedule and administer the dose as soon as possible.
📌 You are receiving this medicine at home through a home healthcare service
→ Contact your healthcare provider as soon as you remember.
💡 Do not attempt to self-administer a double dose.

⚠️ Side Effects of c dime 1000 mg/1000 mg injection

✅ Common Side Effects

Diarrhoea (Common (1-10%))
Stay hydrated and inform your doctor if diarrhoea persists or becomes severe.
Nausea (Common (1-10%))
Report to your doctor if it interferes with eating or drinking.
Vomiting (Common (1-10%))
Inform your doctor if vomiting is persistent or prevents fluid intake.
Injection site pain (Common (1-10%))
Apply a warm compress if advised by your nurse or doctor.
Rash (Common (1-10%))
Report any rash to your doctor; it may indicate an allergy.
Itching (Common (1-10%))
Avoid scratching and inform your doctor if it spreads.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical help immediately if you experience difficulty breathing, swelling of the face or throat, or a sudden drop in blood pressure.
Clostridioides difficile-associated diarrhoea (Uncommon (0.1-1%))
Contact your doctor if you develop severe, persistent, or bloody diarrhoea, even weeks after treatment.
Severe bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice unusual bleeding, bruising, blood in urine or stool, or vomiting blood.
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) (Rare (<0.1%))
Go to the emergency department if you develop a painful rash, blisters, or peeling skin.
Seizures (Rare (<0.1%))
Seek emergency care if you experience a seizure, especially if you have kidney problems.

⚠️ Rare Side Effects

Kidney impairment
Your doctor may monitor kidney function with blood tests; report decreased urine output.
Liver enzyme elevation
Usually reversible; your doctor may monitor liver enzymes.
Low platelet count
Report any unusual bruising or bleeding to your doctor.
Low white blood cell count
Your doctor may check blood counts; report fever or sore throat.
Haemolytic anaemia
Seek medical attention if you feel unusually tired, short of breath, or jaundiced.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Heparin Major
Aminoglycosides Moderate
Loop diuretics Moderate
Probenecid Moderate
Oral contraceptives Minor
Alcohol Minor

🚨 Major Interactions

  • Warfarin
  • Heparin
  • Other anticoagulants or antiplatelet agents

⚡ Moderate Interactions

  • Aminoglycosides
  • Loop diuretics
  • Probenecid

🍷 Alcohol Interaction

Avoid alcohol while receiving this medicine. Alcohol may worsen side effects such as nausea, vomiting, and headache, and may increase the risk of a disulfiram-like reaction.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known severe allergy to cefoperazone, sulbactam, or other beta-lactam antibiotics","Previous anaphylactic reaction to penicillins or cephalosporins","Use in patients with known bleeding disorders unless benefits outweigh risks"]

⚠️ Warnings & Precautions

["Serious allergic reactions, including anaphylaxis, can occur. Stop the infusion and seek emergency care if signs appear.","Clostridioides difficile-associated diarrhoea can occur during or after treatment. Report severe or bloody diarrhoea.","May prolong prothrombin time and increase bleeding risk, especially in patients with vitamin K deficiency or on anticoagulants.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","May cause seizures, particularly in patients with renal impairment or underlying central nervous system disorders.","Do not use for viral infections; it is ineffective against viruses.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi."]

🤱 Lactation Safety

Cefoperazone and sulbactam are excreted in small amounts in breast milk. Consult your doctor before breastfeeding while receiving this medicine; temporary interruption may be advised.

💊 Overdose Management

Overdose with this medicine is unlikely in clinical settings because it is administered by healthcare professionals. If overdose is suspected, treatment should be supportive and symptomatic. Monitor vital signs, kidney function, and neurological status. There is no specific antidote. Cefoperazone and sulbactam can be removed by haemodialysis in severe cases.

⏰ Missed Dose

This medicine is given by a healthcare professional in a hospital or clinic. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.

Additional Safety Advice

General Safety

This medicine must only be given by a qualified healthcare professional in a clinical setting. Before receiving this medicine, tell your doctor about all your allergies, especially any allergy to penicillin, cephalosporins, or other antibiotics. Inform your doctor if you have kidney or liver problems, bleeding disorders, or if you are taking blood thinners such as warfarin. Do not attempt to self-administer this injection at home. While receiving this medicine, your doctor may order blood tests to monitor your liver, kidney, and blood counts. Avoid alcohol during treatment because it may increase the risk of side effects. If you develop severe diarrhoea, unusual bleeding, or signs of an allergic reaction, seek medical help immediately. Do not stop treatment early without consulting your doctor, even if you feel better, because incomplete treatment can lead to resistant infections.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to have reduced kidney function and may require lower doses. They may also be more susceptible to side effects such as bleeding and confusion. Close monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before starting this medicine. The safety of this medicine in pregnancy is not fully established, and it should only be used if clearly needed.

🏥 Post-Surgery Considerations

This medicine may be used after surgery to treat or prevent infections. Your surgeon will determine the appropriate dose and duration based on your condition.

🦷 Dental Procedures

If you are scheduled for a dental procedure, inform your dentist that you are receiving this medicine. No specific precautions are usually needed, but your dentist may consult with your doctor.

💚 Lifestyle Tips for Better Results

🏃
Get plenty of rest to help your body fight the infection.
🥗
Stay well hydrated by drinking plenty of fluids unless advised otherwise.
😴
Eat a balanced diet to support your immune system.
💧
Avoid alcohol during treatment.
🧘
Practice good hand hygiene to prevent the spread of infection.
🌞
Follow up with your doctor as scheduled.

🏋️ Exercise Considerations

While receiving this medicine, you may feel weak or tired. Avoid strenuous exercise until you have recovered. Light activity such as walking may be beneficial, but consult your doctor before resuming your normal exercise routine.

🥗 Diet Recommendations

Drink plenty of water and clear fluids.
Include protein-rich foods to aid recovery.
Eat fruits and vegetables rich in vitamins and minerals.
Avoid alcohol and caffeine if they worsen your symptoms.

💼 Impact on Daily Work & Life

This medicine is given in a hospital or clinic, so you will need to take time off work during treatment. You may feel tired or unwell for a few days. Do not drive or operate heavy machinery if you feel dizzy or weak.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, your doctor may decide to stop the medicine or switch to another antibiotic.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of antibiotic resistance and secondary infections such as fungal overgrowth. Prolonged use may also affect blood counts, liver enzymes, and kidney function. Regular monitoring is advised if treatment is extended beyond the usual duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral antibiotics

For mild infections, oral antibiotics may be used instead of intravenous therapy.

Evidence: Well-established
Other intravenous antibiotics

Depending on the bacteria and resistance patterns, other antibiotics such as ceftriaxone or piperacillin-tazobactam may be used.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor, as the timing may need to be adjusted based on your overall health.

📦 Storage Guide

✅ DO

Store the unreconstituted powder at room temperature (15-30°C).

❌ DON'T

Do not freeze the powder or the reconstituted solution.

✅ DO

Keep the vial in its original carton to protect from light.

❌ DON'T

Do not use if the powder is discoloured or the vial is damaged.

✅ DO

Use the reconstituted solution immediately or store as directed by the manufacturer.

❌ DON'T

Do not store reconstituted solution for longer than recommended.

✈️ Traveling with This Medicine

This medicine is given in a hospital or clinic setting, so travel advice is limited. If you are prescribed a course and need to travel, carry the original packaging and a copy of your prescription. Store the vials at room temperature and protect them from light and moisture. Inform your healthcare provider about your travel plans so that arrangements can be made for administration.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with severe pneumonia
He was admitted to the hospital with high fever and difficulty breathing. He was started on this medicine intravenously. After three days, his fever subsided and his breathing improved. He completed a 10-day course and recovered fully.
💡 Lesson: This medicine can be life-saving in serious bacterial infections when given promptly under medical supervision.
👤 A 35-year-old woman with a complicated urinary tract infection
She had a kidney infection that did not respond to oral antibiotics. She was given this medicine intravenously in the hospital. Her symptoms improved within 48 hours, and she was discharged after five days.
💡 Lesson: Intravenous antibiotics like this medicine are effective for serious infections that do not respond to oral treatment.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working soon after the first dose, but you may not feel better for 24 to 48 hours. Complete the full course as prescribed.

Q: Can I take this medicine at home?

A: No, this medicine must be given intravenously by a healthcare professional in a hospital or clinic.

Q: Is this medicine safe in pregnancy?

A: The safety of this medicine in pregnancy is not fully established. It should only be used if clearly needed and prescribed by your doctor.

Q: What should I do if I experience side effects?

A: Report any side effects to your doctor immediately. Do not stop treatment on your own.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine if I am allergic to penicillin?
  • Will this medicine affect my kidney function?
  • Can I breastfeed while receiving this medicine?
  • How long will I need to stay in the hospital?
  • What if I miss a dose?
  • Can I drink alcohol during treatment?

🔄 Substitutes for c dime 1000 mg/1000 mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure viral infections like the common cold.
    Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections.
  • Myth: This medicine can be self-administered at home.
    Fact: This medicine must be given intravenously by a trained healthcare professional in a clinical setting.
  • Myth: You can stop treatment as soon as you feel better.
    Fact: You must complete the full course prescribed by your doctor to prevent the infection from returning and to avoid antibiotic resistance.

🔄 Alternative Options

Generic Alternatives

  • Cefoperazone and sulbactam injection (generic versions)

Brand Alternatives

  • Assertum 1000 mg/1000 mg injection

📊 Comparison with Similar Medicines

[{"medicine":"Cefoperazone and sulbactam","class":"Third-generation cephalosporin with beta-lactamase inhibitor","route":"Intravenous","common_uses":"Respiratory, urinary, skin, intra-abdominal infections"},{"medicine":"Ceftriaxone","class":"Third-generation cephalosporin","route":"Intravenous or intramuscular","common_uses":"Meningitis, pneumonia, gonorrhoea"},{"medicine":"Piperacillin and tazobactam","class":"Ureidopenicillin with beta-lactamase inhibitor","route":"Intravenous","common_uses":"Hospital-acquired infections, intra-abdominal infections"}]

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