Aurobactum 1000mg/1000mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe diarrhea with abdominal pain or fever
- Unusual bleeding or bruising
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
- Severe skin rash with blistering or peeling
- High fever with chills and worsening symptoms
If experiencing severe symptoms, call emergency services immediately.
What is imex 1000 mg/1000 mg injection used for?
This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and preventing them from destroying the antibiotic. It must be given by a healthcare professional.
- Generic Name: Cefoperazone (1000mg) + Sulbactam (1000mg)
- Manufacturer: Dr. Johns Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imex 1000 mg/1000 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफोपेराज़ोन और सल्बैक्टम का संयोजन है, जिसे इंजेक्शन के रूप में दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे कि फेफड़ों का संक्रमण, मूत्र मार्ग का संक्रमण, त्वचा का संक्रमण, पेट का संक्रमण और रक्त का संक्रमण। यह दवा बैक्टीरिया को मारती है और उन्हें शरीर में फैलने से रोकती है। यह केवल डॉक्टर की देखरेख में अस्पताल में दी जाती है। वायरल संक्रमण जैसे सर्दी-जुकाम के लिए यह दवा प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, चकत्ते, खुजली और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। कुछ रोगियों को सिरदर्द, चक्कर आना या स्वाद में बदलाव महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज बुखार, सांस लेने में कठिनाई, चेहरे या गले में सूजन, त्वचा पर गंभीर चकत्ते, पीलिया, कम पेशाब आना और असामान्य रक्तस्राव शामिल हो सकते हैं। अगर आपको इनमें से कोई भी लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, खासकर एंटीबायोटिक एलर्जी, और किडनी या लीवर की समस्याओं के बारे में बताएं। अगर आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं या स्तनपान करा रही हैं, तो अपने डॉक्टर को सूचित करें। इलाज के दौरान शराब का सेवन न करें। बेहतर महसूस होने पर भी दवा का कोर्स पूरा करें। अपने डॉक्टर के बताए अनुसार नियमित जांच कराएं और किसी भी नए लक्षण की रिपोर्ट करें।
💊 imex 1000 mg/1000 mg injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat pneumonia and bronchitis caused by susceptible bacteria when oral antibiotics are not suitable.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated urinary tract infections and pyelonephritis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious skin infections such as cellulitis and abscesses that require injectable antibiotics.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Treats infections such as peritonitis and intra-abdominal abscesses, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in bloodstream infections caused by susceptible bacteria, especially in hospitalized patients.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease and endometritis caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as part of empirical therapy in cancer patients with fever and low white blood cell counts, though not specifically approved for this indication.","evidence":"Limited"},{"condition":"Surgical prophylaxis","description":"Occasionally used before certain surgeries to prevent infection, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms.
Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Septicemia, Gynecological infections
📋 Drug Information
| Generic Name(s) | Cefoperazone (1000mg) + Sulbactam (1000mg) |
| Brand Name | imex 1000 mg/1000 mg injection |
| Manufacturer | Dr. Johns Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture. After reconstitution, use within the time specified by the manufacturer, usually within 24 hours if refrigerated. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Cefoperazone is a third-generation cephalosporin antibiotic that kills bacteria by binding to penicillin-binding proteins in the bacterial cell wall, preventing the cross-linking of peptidoglycan and causing the bacteria to burst and die. Sulbactam is a beta-lactamase inhibitor that works by irreversibly binding to certain beta-lactamase enzymes produced by bacteria, thereby protecting cefoperazone from being destroyed. This combination extends the antibacterial spectrum of cefoperazone to include many bacteria that would otherwise be resistant.
Mechanism Steps
💡 How to Take imex 1000 mg/1000 mg injection
Strength: Each vial contains cefoperazone sodium equivalent to 1000 mg of cefoperazone and sulbactam sodium equivalent to 1000 mg of sulbactam.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 g to 2 g of cefoperazone combined with 1 g to 2 g of sulbactam, given every 12 hours by intravenous or intramuscular injection. For severe infections, the dose may be increased to 4 g of cefoperazone and 4 g of sulbactam per day, divided into two doses. The exact dose and duration must be individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, kidney and liver function, and clinical response. Do not self-administer; this medicine must be given by a healthcare professional. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, the dose is based on body weight and severity of infection, and must be determined by a qualified pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney and liver function, which can increase the risk of side effects. Dose adjustment may be necessary based on renal and hepatic function. Your doctor will determine the appropriate dose. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced or the dosing interval lengthened. Since cefoperazone is mainly excreted in bile, dose adjustment is primarily needed for sulbactam. Monitor kidney function closely. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with liver impairment, the dose of cefoperazone may need to be reduced. Monitor liver function tests. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 g of cefoperazone and 4 g of sulbactam, divided into two doses. Do not exceed this dose unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imex 1000 mg/1000 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Aminoglycosides | Major | |
| Vancomycin | Major | |
| Furosemide | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Other nephrotoxic drugs (e.g., aminoglycosides, vancomycin)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine and for at least 72 hours after the last dose. Alcohol can cause a disulfiram-like reaction with symptoms such as flushing, severe nausea, vomiting, sweating, and headache. It may also increase the risk of liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefoperazone, sulbactam, or any other cephalosporin or beta-lactam antibiotic","Previous severe allergic reaction (anaphylaxis) to penicillins or cephalosporins","Use in patients with a history of bleeding disorders or on anticoagulants, unless benefits outweigh risks","Use in premature infants or neonates with jaundice, due to risk of kernicterus","Use in patients with severe liver or kidney impairment without dose adjustment"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Emergency treatment should be readily available.","Clostridioides difficile-associated diarrhea can occur during or after treatment. If severe diarrhea develops, stop the medicine and seek medical advice.","This medicine can cause bleeding problems due to hypoprothrombinemia. Monitor PT/INR in at-risk patients.","Use with caution in patients with liver or kidney impairment. Dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi. Monitor for superinfections.","This medicine may cause false-positive results in certain urine glucose tests.","Do not use in patients with a history of penicillin allergy without careful assessment, as cross-reactivity may occur."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in small amounts in breast milk. Caution is advised. Consult your doctor before breastfeeding while on this medicine. If used, monitor the infant for diarrhea, thrush, or rash.
💊 Overdose Management
Overdose with this medicine is unlikely due to its injectable route and administration by healthcare professionals. If overdose is suspected, treatment should be symptomatic and supportive. Monitor vital signs, kidney and liver function, and blood counts. There is no specific antidote. Cefoperazone and sulbactam can be removed by hemodialysis in case of severe toxicity.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer an extra dose. Your healthcare provider will determine the best course of action.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a setting where emergency treatment is available. Before receiving this medicine, tell your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems, bleeding disorders, or stomach or intestinal disease. Do not use this medicine if you have had a severe allergic reaction to any cephalosporin or penicillin antibiotic. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid alcohol during treatment because it may increase the risk of side effects. Do not stop treatment early even if you feel better, as this can lead to incomplete killing of bacteria and resistance. Your doctor may monitor your blood counts, liver function, kidney function, and bleeding time during treatment. Keep all follow-up appointments and report any new or worsening symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney and liver function, which can increase the risk of side effects. Dose adjustment may be necessary. Monitor renal and hepatic function closely. Elderly patients may also be more susceptible to bleeding problems and should be monitored for signs of bleeding.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. This medicine should be used during pregnancy only if clearly needed. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. If you have recently had surgery, inform your surgeon and anesthesiologist that you are receiving this medicine. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend postponing non-urgent dental work until you have completed treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activity such as walking is generally safe, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic setting, so you may need to take time off work or adjust your schedule for treatment. You may feel tired or dizzy, so avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can resume normal activities after completing treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will decide when to stop based on your clinical response and test results. If you experience serious side effects, your doctor may stop the medicine and switch to an alternative.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Prolonged use may also affect liver and kidney function, and blood counts. Regular monitoring is required if prolonged therapy is necessary. When used appropriately for short courses, long-term effects are uncommon.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria and its susceptibility, other antibiotics such as ceftriaxone, piperacillin-tazobactam, or meropenem may be used.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, if you are due for any vaccinations, inform your doctor, as antibiotics may affect the response to certain live vaccines. Generally, it is safe to receive vaccines while on this medicine, but consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, it must be administered by a healthcare professional. Carry your prescription and medical records with you. If you are traveling with the medicine, keep it in its original packaging and store it at room temperature, away from direct sunlight. Check with your airline and destination country about regulations for carrying injectable medicines. It is best to arrange for administration at a medical facility at your destination. Do not attempt to self-administer while traveling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 48 to 72 hours after starting treatment, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Tell your doctor about any allergy to penicillin or other antibiotics. This medicine may not be suitable for you if you have had a severe allergic reaction to penicillins.
A: It should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.
A: This medicine may cause dizziness. Avoid driving or operating machinery until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for imex 1000 mg/1000 mg injection
View AllAlternative brands with exact same active ingredient:
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c bactum 1000mg/1000mg injectionVhb Life Sciences Inc ₹61.60 47.4% CHEAPER
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cefactam 1000mg/1000mg injectionVeritaz Healthcare Ltd ₹63.75 45.6% CHEAPER
-
ulzone s 1000mg/1000mg injectionUltratech Pharmaceuticals ₹103.13 12% CHEAPER
-
zorok 1000 mg/1000 mg injectionAstrum Healthcare Pvt Ltd ₹129.47 10.5% COSTLIER
-
c dime 1000mg/1000mg injectionEmcure Pharmaceuticals Ltd ₹139.30 18.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against susceptible bacteria. It is not effective against viral infections like the common cold or flu. - Myth: You can stop this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to take without a doctor's supervision.
Fact: This is a prescription injectable antibiotic that must only be given by a healthcare professional in a medical setting.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone and sulbactam injection (generic)
Brand Alternatives
- Aurobactum 1000mg/1000mg injection